• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

BAFF Receptor (TNFRSF13C) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS621540

Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF, BLyS, TALL-1, THANK, and zTNF4. BAFF/BLyS was characterized as a B cell activator… More details

$850 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BAFF Receptor (TNFRSF13C), Polyclonal Antibody
Full Product Name
BAFF Receptor (BAFF-R, BR3, BLyS Receptor 3)
Product Gene Name
anti-TNFRSF13C antibody
Product Synonym Names
Anti -BAFF Receptor (BAFF-R, BR3, BLyS Receptor 3)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human BAFF-R. Species Crossreactivity: mouse, rat
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
18,864 Da
Chromosome Location
Chromosome: 22; NC_000022.10 (42321036..42322821, complement). Location: 22q13.1-q13.31
3D Structure
ModBase 3D Structure for Q5H8V1
Immunogen
Synthetic peptide corresponding to the C-terminus of human BAFF-R (aa169-183, NH2-GSTELVTTKTAGPEQ-COOH) (6). The peptide sequence is identical between human and mouse origin (6).
Positive Control
Mouse spleen tissue lysate

Product Categories/Family for anti-TNFRSF13C antibody

Antibodies; Abs to Apoptosis
Applications Tested/Suitable for anti-TNFRSF13C antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-TNFRSF13C antibody
Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: Western Blot: 2-5ug/ml
Immunohistochemistry: 5ug/ml

Western Blot (WB) of anti-TNFRSF13C antibody

Western blot analysis of BAFF-R in human (H), mouse (M), and rat (R) spleen tissue lysates with MBS621540 at 5ug/ml.
Rabbit Anti-TNFRSF13C Polyclonal Antibody – Cat# MBS621540

Immunohistochemistry (IHC) of anti-TNFRSF13C antibody

Immunohistochemistry of BAFF-R in human tonsil tissue with MBS621540 at 5ug/ml.
Rabbit Anti-TNFRSF13C Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS621540

Other Notes

Small volumes of anti-TNFRSF13C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNFRSF13C purchase

MBS621540 is an antibody targeting TNFRSF13C. Also known as BAFF Receptor (BAFF-R, BR3, BLyS Receptor 3). Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFRSF13C. It may not necessarily be applicable to this product.

NCBI GI #
15208475
NCBI GeneID
115650
UniProt Primary Accession #
Q5H8V1
UniProt Related Accession #
Q5H8V1; Q96RJ3
NCBI Official Full Name
BAFF receptor
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 13C
NCBI Official Symbol
TNFRSF13C
NCBI Official Synonym Symbols
BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin; MGC138235
UniProt Protein Name
BAFF receptor
Protein Family
Tumor necrosis factor receptor superfamily
UniProt Gene Name
TNFRSF13C
UniProt Synonym Gene Names
BAFF-R
UniProt Entry Name
Q5H8V1_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 13C; BAFF receptor; BLyS receptor 3; OTTHUMP00000199650; B cell-activating factor receptor; B-cell-activating factor receptor

NCBI Summary for TNFRSF13C

B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq]
Show more

UniProt Comments for TNFRSF13C

BAFF-R: B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4); also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.; Cell cycle regulation; Cell surface

Chromosomal Location of Human Ortholog: 22q13.1-q13.31

Cellular Component: integral to membrane; external side of plasma membrane

Biological Process: B cell costimulation; B cell homeostasis; T cell costimulation; positive regulation of germinal center formation; positive regulation of B cell proliferation; positive regulation of T cell proliferation; positive regulation of interferon-gamma biosynthetic process

Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 4
Show more

Research Articles on TNFRSF13C

1. BLyS and its receptors might have a potential role in the growth and survival of malignant plasma cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TNFRSF13C antibody

 Reference Product  PubMed Publications
 TNFSF13B antibody  >99 publications with TNFRSF13C and TNFSF13B
 TRAF3 antibody  >7 publications with TNFRSF13C and TRAF3

Pathways associated with anti-TNFRSF13C antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram

Diseases associated with anti-TNFRSF13C antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >42 publications with TNFRSF13C and Neoplasms
 Inflammation Antibodies  >19 publications with TNFRSF13C and Inflammation
 Common Variable Immunodeficiency Antibodies  >10 publications with TNFRSF13C and Common Variable Immunodeficiency
 Kidney Diseases Antibodies  >7 publications with TNFRSF13C and Kidney Diseases
 Hyperplasia Antibodies  >6 publications with TNFRSF13C and Hyperplasia
 Neoplasms, Experimental Antibodies  >3 publications with TNFRSF13C and Neoplasms, Experimental
 Liver Diseases Antibodies  >2 publications with TNFRSF13C and Liver Diseases
 Cell Transformation, Neoplastic Antibodies  >2 publications with TNFRSF13C and Cell Transformation, Neoplastic
 Adenocarcinoma Antibodies  >1 publications with TNFRSF13C and Adenocarcinoma
 Arteriosclerosis Antibodies  >1 publications with TNFRSF13C and Arteriosclerosis

Organs/Tissues associated with anti-TNFRSF13C antibody

 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >13 publications with TNFRSF13C and Lymph Node
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000