Protein Kinase, Interferon-Inducible Double Stranded RNA-Activated Protein Kinase Antibody – Rabbit Polyclonal

EIF-2alpha, also known as eukaryotic translation initiation factor 2alpha, promotes the binding of the initiator tRNA to the 40S ribosomal subunits and controls translational rates via phosphorylation/dephosphorylation mechanisms. The double-stranded RNA (dsRNA)-activated protein kinase (PKR) provides an important control in the regulation of protein synthesis initiation through the phosphorylation of eIF-2alpha. Phosphorylated eIF-2 alpha inhibits cell growth and induces apoptosis. Phosphorylation of eIF-2alpha occurs under a variety of conditions including viral infection, apoptosis, nutrient deprivation, heme-deprivation, and certain stresses. EIF-2 exists as a heterotrimeric protein composed of 3 nonidentical subunits, alpha (36kD), beta (38kD), and gamma (52kD).

Small volumes of anti-Protein Kinase, Interferon-Inducible Double Stranded RNA-Activated Protein Kinase antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS621563 is an antibody targeting Protein Kinase, Interferon-Inducible Double Stranded RNA-Activated Protein Kinase. Also known as Protein Kinase, Interferon-Inducible Double Stranded RNA-Activated Protein Kinase (PRKR, EC 2.7.11.1, EIF2AK1, EIF2AK2, MGC126524). Reactive in Human. Host: Rabbit.