Activin Receptor Type IIA (ACVR2A) Antibody – Goat Polyclonal

ACVR2A: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active.

Protein type: Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Motility/polarity/chemotaxis; Kinase, protein; EC 2.7.11.30; Membrane protein, integral; TKL group; STKR family; Type2 subfamily

Cellular Component: cell surface; cytoplasm; integral to membrane; activin receptor complex; receptor complex

Molecular Function: protein serine/threonine kinase activity; activin receptor activity; protein self-association; growth factor binding; metal ion binding; activin binding; coreceptor activity; activin receptor activity, type II; transmembrane receptor protein serine/threonine kinase activity; ATP binding; receptor signaling protein serine/threonine kinase activity; PDZ domain binding

Biological Process: positive regulation of erythrocyte differentiation; embryonic skeletal development; male gonad development; regulation of BMP signaling pathway; activin receptor signaling pathway; regulation of signal transduction; Sertoli cell proliferation; gastrulation with mouth forming second; positive regulation of bone mineralization; protein amino acid phosphorylation; response to organic substance; anterior/posterior pattern formation; BMP signaling pathway; positive regulation of osteoblast differentiation; positive regulation of activin receptor signaling pathway; mesoderm development; spermatogenesis; positive regulation of protein amino acid phosphorylation; positive regulation of follicle-stimulating hormone secretion; regulation of nitric-oxide synthase activity; sperm ejaculation; determination of left/right symmetry; penile erection