Rabbit Anti-SLC12A3 Polyclonal Antibody – Cat# MBS621617

Solute Carrier Family 12a3 (SLC12A3) Antibody – Rabbit Polyclonal

Name: SLC12A3 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS621617
Price: 700 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS621617

Slc12a3, a thiazide-sensitive NaCl co-transporter, is found on the apical membrane of the distal convoluted tubule, where it is the principal mediator of Na+ and Clreabsorption in this segment of the nephron. It is activated by phosphorylation, and has been… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Solute Carrier Family 12a3 (SLC12A3), Polyclonal Antibody

Full Product Name

Solute Carrier Family 12a3 (Slc12a3, Sodium/chloride transporters, member 3, Na-Cl symporter, NCC, Solute carrier family 12 member 3, Thiazide- sensitive sodium-chloride cotransporter, Tsc, TSC)

Product Gene Name

anti-SLC12A3 antibody

Product Synonym Names

Anti -Solute Carrier Family 12a3 (Slc12a3, Sodium/chloride transporters, member 3, Na-Cl symporter, NCC, Solute carrier family 12 member 3, Thiazide- sensitive sodium-chloride cotransporter, Tsc, TSC)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

Supplied as a liquid in 0.1% BSA, 1mM sodium azide, 50% glycerol.

Purity/Purification

Serum
Serum

Specificity

Recognizes rat Slc12a3. Species Crossreactivity: Mouse, human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

113,139 Da

Chromosome Location

Chromosome: 16; NC_000016.9 (56899119..56949762). Location: 16q13

OMIM

263800

3D Structure

ModBase 3D Structure for P55017

Immunogen

Synthetic peptide corresponding to aa74-95 of the N-terminal tail of rat Slc12a3 (NP_062218).

Product Categories/Family for anti-SLC12A3 antibody

Antibodies; Abs to Ion Channel

Applications Tested/Suitable for anti-SLC12A3 antibody

Western Blot (WB)

Application Notes for anti-SLC12A3 antibody

Suitable for use in Western Blot.
Dilution: Western Blot: 1:1000

Other Notes

Small volumes of anti-SLC12A3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLC12A3 purchase

MBS621617 is an antibody targeting SLC12A3. Also known as Solute Carrier Family 12a3 (Slc12a3, Sodium/chloride transporters, member 3, Na-Cl symporter, NCC, Solute carrier family 12 member 3, Thiazide- sensitive sodium-chloride cotransporter, Tsc, TSC). Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC12A3. It may not necessarily be applicable to this product.

NCBI GI #

186910319

NCBI GeneID

6559

NCBI Accession #

NP_001119580.1

UniProt Primary Accession #

P55017

UniProt Secondary Accession #

A8MSJ2; C9JNN9

UniProt Related Accession #

P55017

GenBank Nucleotide #

NM_001126108.1

NCBI Official Full Name

solute carrier family 12 member 3 isoform 3

NCBI Official Synonym Full Names

solute carrier family 12 (sodium/chloride transporters), member 3

NCBI Official Symbol

SLC12A3

NCBI Official Synonym Symbols

TSC; NCCT; FLJ96318

UniProt Protein Name

Solute carrier family 12 member 3

UniProt Synonym Protein Names

Na-Cl symporter; Thiazide-sensitive sodium-chloride cotransporter

Protein Family

Solute carrier family

UniProt Gene Name

SLC12A3

UniProt Synonym Gene Names

TSC

UniProt Entry Name

S12A3_HUMAN

NCBI Protein Information

solute carrier family 12 member 3; Na-Cl symporter; OTTHUMP00000164385; thiazide-sensitive Na-Cl cotransporter; thiazide-sensitive sodium-chloride cotransporter; NaCl electroneutral thiazide-sensitive cotransporter

NCBI Summary for SLC12A3

This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

UniProt Comments for SLC12A3

NCCT: Key mediator of sodium and chloride reabsorption in this nephron segment, accounting for a significant fraction of renal sodium reabsorption. Interacts with KLHL3. Predominant in kidney. Activated by WNK3. Belongs to the SLC12A transporter family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: membrane; integral to plasma membrane; apical plasma membrane; plasma membrane; cytosol

Molecular Function: protein binding; transporter activity; sodium:chloride symporter activity

Biological Process: transport; sodium ion transport; chloride transport; ion transport; transmembrane transport

Disease: Gitelman Syndrome

Research Articles on SLC12A3

1. likely that the c.1196_1202dup7bp mutation in the SLC12A3 gene reflects the presence of a common ancestor in Gitelman syndrome an area covering the northern-central part of Italy and eastern France.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLC12A3 antibody

Reference Product	PubMed Publications
WNK4 antibody	>14 publications with SLC12A3 and WNK4

Pathways associated with anti-SLC12A3 antibody

Products by Pathway	Pathway Diagram
Cation-coupled Chloride Cotransporters Pathway antibodies	Cation-coupled Chloride Cotransporters Pathway Diagram
SLC-mediated Transmembrane Transport Pathway antibodies	SLC-mediated Transmembrane Transport Pathway Diagram
Transmembrane Transport Of Small Molecules Pathway antibodies	Transmembrane Transport Of Small Molecules Pathway Diagram
Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway antibodies	Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway Diagram

Diseases associated with anti-SLC12A3 antibody

Disease Name	Pubmed Publications
Kidney Diseases Antibodies	>106 publications with SLC12A3 and Kidney Diseases
Gitelman Syndrome Antibodies	>69 publications with SLC12A3 and Gitelman Syndrome
Hypertension Antibodies	>54 publications with SLC12A3 and Hypertension
Cardiovascular Diseases Antibodies	>37 publications with SLC12A3 and Cardiovascular Diseases
Hypercalciuria Antibodies	>9 publications with SLC12A3 and Hypercalciuria
Diabetic Nephropathies Antibodies	>7 publications with SLC12A3 and Diabetic Nephropathies
Renal Insufficiency Antibodies	>7 publications with SLC12A3 and Renal Insufficiency
Acidosis Antibodies	>5 publications with SLC12A3 and Acidosis
Proteinuria Antibodies	>5 publications with SLC12A3 and Proteinuria
Abnormalities, Multiple Antibodies	>3 publications with SLC12A3 and Abnormalities, Multiple

Organs/Tissues associated with anti-SLC12A3 antibody

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>115 publications with SLC12A3 and Kidney
Mixed Antibodies	>2 publications with SLC12A3 and Mixed
Placenta Antibodies	>1 publications with SLC12A3 and Placenta