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Neurotensin (NTS) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS621740

Neurotensin (NT) is an endogenous tridecapeptide neurotransmitter (pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg- pro-Tyr-Ile-Leu-OH) that was originally isolated from bovine hypothalamus. NT influences distinct central and peripheral physiological functions in… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Neurotensin (NTS), Polyclonal Antibody
Full Product Name
Neurotensin, NT (Human Proneurotensin, Large Neuromedin N, Neuromedin N Preproprotein, NMN-125, NN, NT, NT/N, NTRH, NTS, NTS1, Proneuromedin N mRNA, Tail Peptide)
Product Gene Name
anti-NTS antibody
Product Synonym Names
Anti -Neurotensin, NT (Human Proneurotensin, Large Neuromedin N, Neuromedin N Preproprotein, NMN-125, NN, NT, NT/N, NTRH, NTS, NTS1, Proneuromedin N mRNA, Tail Peptide)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.05% sodium azide.
Purity/Purification
Serum
Serum
Specificity
Recognizes human Neurotensin, NT. No significant sequence homology exist with other neuromedins.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
19,795 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (86268073..86276770). Location: 12q21
OMIM
162650
3D Structure
ModBase 3D Structure for P30990
Immunogen
Synthetic peptide of Human NT, 13aa in the N-terminus. Species sequence homology: 100% mouse, rat, bovine, canine and 92% in G. pig.

Product Categories/Family for anti-NTS antibody

Antibodies; Abs to Neuroscience
Applications Tested/Suitable for anti-NTS antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-NTS antibody
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:1000-1:5000 using ECL.
ELISA: 1:100,000 using 50-100ng control peptide/well.

Other Notes

Small volumes of anti-NTS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NTS purchase

MBS621740 is an antibody targeting NTS. Also known as Neurotensin, NT (Human Proneurotensin, Large Neuromedin N, Neuromedin N Preproprotein, NMN-125, NN, NT, NT/N, NTRH, NTS, NTS1, Proneuromedin N mRNA, Tail Peptide). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NTS. It may not necessarily be applicable to this product.

NCBI GI #
5453816
NCBI GeneID
4922
NCBI Accession #
NP_006174.1
UniProt Primary Accession #
P30990
UniProt Related Accession #
P30990
GenBank Nucleotide #
NM_006183.4
NCBI Official Full Name
neurotensin/neuromedin N preproprotein
NCBI Official Synonym Full Names
neurotensin
NCBI Official Symbol
NTS
NCBI Official Synonym Symbols
NN; NT; NT/N; NTS1; NMN-125
UniProt Protein Name
Neurotensin/neuromedin N
UniProt Synonym Protein Names
NmN-125
Protein Family
Neurotensin
UniProt Gene Name
NTS
UniProt Synonym Gene Names
NN; NmN; NT
UniProt Entry Name
NEUT_HUMAN
NCBI Protein Information
neurotensin/neuromedin N; pro-neurotensin/neuromedin

NCBI Summary for NTS

This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. [provided by RefSeq, Jul 2008]
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UniProt Comments for NTS

NTS: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle. Belongs to the neurotensin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 12q21

Cellular Component: transport vesicle; extracellular region

Molecular Function: neuropeptide hormone activity; protein binding

Biological Process: signal transduction; regulation of blood vessel size
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Research Articles on NTS

1. Nanoparticles exposing neurotensin tumor-specific drivers.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NTS antibody

 Reference Product  PubMed Publications
 CCK antibody  >110 publications with NTS and CCK
 NTSR1 antibody  >10 publications with NTS and NTSR1
 NTSR2 antibody  >7 publications with NTS and NTSR2
 GRP antibody  >4 publications with NTS and GRP
 TAC1 antibody  >3 publications with NTS and TAC1
 NMU antibody  >1 publications with NTS and NMU

Pathways associated with anti-NTS antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with anti-NTS antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >389 publications with NTS and Cardiovascular Diseases
 Hypertension Antibodies  >349 publications with NTS and Hypertension
 Nervous System Diseases Antibodies  >285 publications with NTS and Nervous System Diseases
 Bradycardia Antibodies  >260 publications with NTS and Bradycardia
 Hypotension Antibodies  >184 publications with NTS and Hypotension
 Inflammation Antibodies  >165 publications with NTS and Inflammation
 Brain Diseases Antibodies  >154 publications with NTS and Brain Diseases
 Disease Models, Animal Antibodies  >149 publications with NTS and Disease Models, Animal
 Heart Diseases Antibodies  >115 publications with NTS and Heart Diseases
 Kidney Diseases Antibodies  >108 publications with NTS and Kidney Diseases

Organs/Tissues associated with anti-NTS antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2990 publications with NTS and Brain
 Heart Antibodies  >793 publications with NTS and Heart
 Kidney Antibodies  >190 publications with NTS and Kidney
 Stomach Antibodies  >142 publications with NTS and Stomach
 Intestine Antibodies  >69 publications with NTS and Intestine
 Skin Antibodies  >48 publications with NTS and Skin
 Mouth Antibodies  >47 publications with NTS and Mouth
 Connective Tissue Antibodies  >28 publications with NTS and Connective Tissue
 Pancreas Antibodies  >23 publications with NTS and Pancreas
 Embryonic Tissue Antibodies  >19 publications with NTS and Embryonic Tissue
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