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Glycine Receptor Alpha 3 Subunit (GLRA3) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS621830

Glycine receptor a3 subunit, also known as GLRA3, belongs to the ligand-gated ion channel family. Glycine functions as a inhibitory neurotransmitter throughout the CNS of mammals. The Glycine receptor is a neurotransmitter ligand-gated ion channel. GLRA3 is a… More details

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Product Overview

Online Datasheet in PDF
Product Name
Glycine Receptor alpha 3 subunit (GLRA3), Polyclonal Antibody
Full Product Name
Glycine Receptor alpha 3 subunit (GLRA3, ligand gated ion channel, glycine receptor, alpha-3 polypeptide, glycine receptor, alpha 3)
Product Gene Name
anti-GLRA3 antibody
Product Synonym Names
Anti -Glycine Receptor alpha 3 subunit (GLRA3, ligand gated ion channel, glycine receptor, alpha-3 polypeptide, glycine receptor, alpha 3)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human Glycine Receptor a3 subunit at ~48kD.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Chromosome Location
Chromosome: 4; NC_000004.11 (175563198..175750465, complement). Location: 4q33-q34
OMIM
600421
3D Structure
ModBase 3D Structure for O75311
Immunogen
Synthetic peptide from the C-terminus of human GLRA3, conjugated to KLH (Accession #NP_006520.2).
Cellular Localization
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Species Sequence Homology
Rat 92%
Cross Reactivity
Mouse
Positive Control
Fetal human brain tissue lysate

Product Categories/Family for anti-GLRA3 antibody

Antibodies; Abs to Receptors
Applications Tested/Suitable for anti-GLRA3 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-GLRA3 antibody
Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Western Blot: 0.1ug/ml detected glycine receptor alpha 3 subunit on 10ug of fetal human brain tissue lysate.
Immunohistochemistry (Paraffin): 1:100-1:500 detected Glycine Receptor alpha 3 subunit in mouse spinal cord and mouse eye tissue.
Western Blot: 0.1ug/ml

Immunohistochemistry (IHC) of anti-GLRA3 antibody

IHC Analysis: Representative staining pattern on formalin-fixed, paraffin- embedded mouse spinal cord. Tissue was pretreated with citrate, pH 6.0 using antigen retrieval techniques. MBS621830 diluted to 1:100-500.
Rabbit Anti-GLRA3 Polyclonal Antibody – Cat# MBS621830

Immunohistochemistry (IHC) of anti-GLRA3 antibody

IHC Analysis: Representative staining pattern on formalin-fixed, paraffin- embedded mouse eye. Tissue pretreated with citrate, pH 6.0 using antigen retrieval techniques. MBS621830 diluted to 1:100-1:300.
Rabbit Anti-GLRA3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS621830

Western Blot (WB) of anti-GLRA3 antibody

Western Blot Analysis: Fetal human brain lysate was resolved by electrophoresis, transferred to PVDF and probed with MBS621830. Proteins were visualized using IgG (HRP) Pab donkey x rabbit secondary antibody and a chemiluminescence detection system. Arrow indicates Glycine Receptor a3 subunit (48kD).
Rabbit Anti-GLRA3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS621830

Other Notes

Small volumes of anti-GLRA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GLRA3 purchase

MBS621830 is an antibody targeting GLRA3. Also known as Glycine Receptor alpha 3 subunit (GLRA3, ligand gated ion channel, glycine receptor, alpha-3 polypeptide, glycine receptor, alpha 3). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GLRA3. It may not necessarily be applicable to this product.

NCBI GI #
110347441
NCBI GeneID
8001
NCBI Accession #
NP_006520.2
UniProt Primary Accession #
O75311
UniProt Secondary Accession #
O75816; Q5D0E3; D3DP44
UniProt Related Accession #
O75311; Q4W595; Q9UPF3
GenBank Nucleotide #
NM_006529.2
NCBI Official Full Name
glycine receptor subunit alpha-3 isoform a
NCBI Official Synonym Full Names
glycine receptor, alpha 3
NCBI Official Symbol
GLRA3
NCBI Official Synonym Symbols
GLRA3
UniProt Protein Name
Glycine receptor subunit alpha-3
Protein Family
Glycine receptor
UniProt Gene Name
GLRA3
UniProt Entry Name
GLRA3_HUMAN
NCBI Protein Information
glycine receptor subunit alpha-3; OTTHUMP00000194692; OTTHUMP00000194693; ligand gated ion channel; glycine receptor alpha 3 subunit; glycine receptor, alpha-3 polypeptide

NCBI Summary for GLRA3

The GLRA3 gene encodes the alpha-3 subunit of the neuronal glycine receptor, a ligand-gated chloride channel composed of ligand-binding alpha and structural beta polypeptides (Kingsmore et al., 1994 [PubMed 7894176]).[supplied by OMIM]

UniProt Comments for GLRA3

GLRA3: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing). Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA3 sub- subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Transporter; Transporter, ion channel; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q34.1

Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction

Molecular Function: transmitter-gated ion channel activity; extracellular-glycine-gated chloride channel activity; glycine binding

Biological Process: transmembrane transport
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Research Articles on GLRA3

1. Results indicate that the multifunctional basic motif of the TM3-4 loop is capable of mediating a karyopherin-dependent intracellular sorting of full-length GlyRs.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GLRA3 antibody

 Products by Pathway  Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Ligand-gated Ion Channel Transport Pathway antibodies  Ligand-gated Ion Channel Transport Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-GLRA3 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1 publications with GLRA3 and Inflammation
 Autistic Disorder Antibodies  >1 publications with GLRA3 and Autistic Disorder
 Carcinoma Antibodies  >1 publications with GLRA3 and Carcinoma
 Lung Diseases Antibodies  >1 publications with GLRA3 and Lung Diseases
 Carcinoma, Non-Small-Cell Lung Antibodies  >1 publications with GLRA3 and Carcinoma, Non-Small-Cell Lung
 Lung Neoplasms Antibodies  >1 publications with GLRA3 and Lung Neoplasms
 Memory Disorders Antibodies  >1 publications with GLRA3 and Memory Disorders
 Neoplasms Antibodies  >1 publications with GLRA3 and Neoplasms

Organs/Tissues associated with anti-GLRA3 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with GLRA3 and Brain
 Blood Antibodies  >1 publications with GLRA3 and Blood
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