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Synaptonemal Complex Protein 3 (SYCP3) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS621998

The synaptonemal complex is a proteinaceous complex that apparently mediates synapses during the zygotene stage and then disintegrates. It is a complex structure that unites homologous chromosomes during the prophase stage of meiosis. It is the result of… More details

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Product Overview

Online Datasheet in PDF
Product Name
Synaptonemal Complex Protein 3 (SYCP3), Polyclonal Antibody
Full Product Name
Synaptonemal Complex Protein 3 (SCP3, SCP-3, SYCP3, COR1, MGC71888, RNASCP3) (HRP)
Product Gene Name
Product Synonym Names
Anti -Synaptonemal Complex Protein 3 (SCP3, SCP-3, SYCP3, COR1, MGC71888, RNASCP3) (HRP)
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide. Labeled with HRP.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes mouse synaptonemal complex protein 3.
Preparation and Storage
Store at 2-8 degree C. Do Not Freeze! Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.
Molecular Weight
27,729 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (102122426..102133250, complement). Location: 12q
OMIM
270960
3D Structure
ModBase 3D Structure for Q8IZU3
Immunogen
A synthetic peptide made to the C-terminal region of the mouse SCP3 protein.
Applications Tested/Suitable for anti-SYCP3 antibody
Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-SYCP3 antibody
Suitable for use in Immunoflourescence and Immunohistochemistry.
Dilution: Immunoflourescence: 1:100-1:750
Immunohistochemistry (paraffin): 1:750
Optimal dilutions to be determined by researcher.

Testing Data of anti-SYCP3 antibody

SPC3 labeled with mouse pachytene preparation (red), using S9106-92B CDK2 staining, near teleomeresis also present (green).
Rabbit Anti-SYCP3 Polyclonal Antibody – Cat# MBS621998

Testing Data of anti-SYCP3 antibody

Punctate staining of murine SCP3 in mouse ovary using S9106-92B.
Rabbit Anti-SYCP3 Polyclonal Antibody, Testing Data – Cat# MBS621998

Other Notes

Small volumes of anti-SYCP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SYCP3 purchase

MBS621998 is an antibody targeting SYCP3. Also known as Synaptonemal Complex Protein 3 (SCP3, SCP-3, SYCP3, COR1, MGC71888, RNASCP3) (HRP). Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SYCP3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
synaptonemal complex protein 3
NCBI Official Synonym Full Names
synaptonemal complex protein 3
NCBI Official Symbol
SYCP3
NCBI Official Synonym Symbols
COR1; SCP3; MGC71888
UniProt Protein Name
Synaptonemal complex protein 3
UniProt Gene Name
SYCP3
UniProt Synonym Gene Names
SCP3
UniProt Entry Name
SYCP3_HUMAN
NCBI Protein Information
synaptonemal complex protein 3; OTTHUMP00000196388; OTTHUMP00000196389; OTTHUMP00000196390

NCBI Summary for SYCP3

This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq]
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UniProt Comments for SYCP3

SYCP3: Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for testis development. Defects in SYCP3 are the cause of spermatogenic failure type 4 (SPGF4). An infertility disorder characterized by azoospermia, a condition of having no sperm present in the ejaculate. Testicular histology shows arrest of spermatogenesis at the pachytene stage of primary spermatocytes. Belongs to the XLR/SYCP3 family.

Chromosomal Location of Human Ortholog: 12q

Cellular Component: chromosome; nucleus

Molecular Function: DNA binding

Biological Process: male meiosis I; cell division; spermatogenesis, exchange of chromosomal proteins

Disease: Spermatogenic Failure 4
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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