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CDCA8 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6220579

CDCA8 is a component of a chromosomal passenger complex required for stability of the bipolar mitotic spindle (Gassmann et al., 2004 [PubMed 15249581]). More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CDCA8, Monoclonal Antibody
Full Product Name
CDCA8 (CDCA8, PESCRG3, Borealin, Dasra-B, Cell division cycle-associated protein 8, Pluripotent embryonic stem cell-related gene 3 protein) (MaxLight 650)
Product Gene Name
anti-CDCA8 antibody
Product Synonym Names
CDCA8; PESCRG3; Borealin; Dasra-B; Cell division cycle-associated protein 8; Pluripotent embryonic stem cell-related gene 3 protein
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
181CT41.2.3
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.
Purity/Purification
Purified by Protein G Affinity Chromatography
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
OMIM
609977
3D Structure
ModBase 3D Structure for Q53HL2
Immunogen
CDCA8 Mab is generated from mouse immunized with CDCA8 recombinant protein.
Conjugate
MaxLight650

Product Categories/Family for anti-CDCA8 antibody

Antibodies; Cell Division Cycle (CDC)
Applications Tested/Suitable for anti-CDCA8 antibody
FLISA, Western Blot (WB)
Application Notes for anti-CDCA8 antibody
FLISA: 1:1000
WB: 1:100-500
Applications are based on unconjugated antibody.

Product References and Citations for anti-CDCA8 antibody

Bourhis, E., et al. Biochemistry 48(29):6783-6793(2009) Zhang, Q., et al. Mol. Biol. Rep. 36(3):603-609(2009) Klein, U.R., et al. Mol. Biol. Cell 20(1):410-418(2009) Xia, F., et al. Mol. Cell. Biol. 28(17):5299-5311(2008) Jelluma, N., et al. Cell 132(2):233-246(2008)

Other Notes

Small volumes of anti-CDCA8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDCA8 purchase

MBS6220579 is an antibody targeting CDCA8. Also known as CDCA8 (CDCA8, PESCRG3, Borealin, Dasra-B, Cell division cycle-associated protein 8, Pluripotent embryonic stem cell-related gene 3 protein) (MaxLight 650). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CDCA8. It may not necessarily be applicable to this product.

NCBI GI #
8922438
NCBI GeneID
55143
NCBI Accession #
NP_060571.1
UniProt Primary Accession #
Q53HL2
UniProt Related Accession #
Q53HL2
GenBank Nucleotide #
NM_018101.3
NCBI Official Full Name
borealin
NCBI Official Synonym Full Names
cell division cycle associated 8
NCBI Official Symbol
CDCA8
NCBI Official Synonym Symbols
BOR; DasraB; MESRGP; BOREALIN
UniProt Protein Name
Borealin
UniProt Synonym Protein Names
Cell division cycle-associated protein 8; Dasra-B; hDasra-B; Pluripotent embryonic stem cell-related gene 3 protein
UniProt Gene Name
CDCA8
UniProt Synonym Gene Names
PESCRG3; hDasra-B
UniProt Entry Name
BOREA_HUMAN
NCBI Protein Information
borealin

NCBI Summary for CDCA8

This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]
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UniProt Comments for CDCA8

Borealin: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. Belongs to the borealin family.

Protein type: Cell cycle regulation; Nucleolus

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: intercellular bridge; protein complex; nucleolus; spindle; midbody; nucleus; cytosol; chromosome, pericentric region; chromocenter

Molecular Function: protein binding

Biological Process: cell division; mitotic cell cycle; mitotic metaphase plate congression; chromosome organization and biogenesis
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Research Articles on CDCA8

1. Results indicate that higher CDCA8 expression in breast cancer cells is positively associated with poor prognosis and suggest that CDCA8 is a key mediator of estrogen-stimulated breast cancer cell growth and survival.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CDCA8 antibody

 Reference Product  PubMed Publications
 BIRC5 antibody  >26 publications with CDCA8 and BIRC5
 INCENP antibody  >24 publications with CDCA8 and INCENP
 AURKB antibody  >24 publications with CDCA8 and AURKB
 KIF2C antibody  >3 publications with CDCA8 and KIF2C
 CENPF antibody  >1 publications with CDCA8 and CENPF
 KIF20A antibody  >1 publications with CDCA8 and KIF20A
 PLK1 antibody  >1 publications with CDCA8 and PLK1
 CDC20 antibody  >1 publications with CDCA8 and CDC20

Pathways associated with anti-CDCA8 antibody

 Products by Pathway  Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Anaphase Pathway antibodies  Mitotic Anaphase Pathway Diagram
 Mitotic Metaphase And Anaphase Pathway antibodies  Mitotic Metaphase And Anaphase Pathway Diagram
 Mitotic Prometaphase Pathway antibodies  Mitotic Prometaphase Pathway Diagram
 Resolution Of Sister Chromatid Cohesion Pathway antibodies  Resolution Of Sister Chromatid Cohesion Pathway Diagram
 Separation Of Sister Chromatids Pathway antibodies  Separation Of Sister Chromatids Pathway Diagram

Diseases associated with anti-CDCA8 antibody

 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >2 publications with CDCA8 and Lung Diseases
 Cell Transformation, Neoplastic Antibodies  >2 publications with CDCA8 and Cell Transformation, Neoplastic
 Ovarian Neoplasms Antibodies  >2 publications with CDCA8 and Ovarian Neoplasms
 Lung Neoplasms Antibodies  >2 publications with CDCA8 and Lung Neoplasms
 Anemia Antibodies  >1 publications with CDCA8 and Anemia
 Adenocarcinoma Antibodies  >1 publications with CDCA8 and Adenocarcinoma
 Uterine Cervical Neoplasms Antibodies  >1 publications with CDCA8 and Uterine Cervical Neoplasms

Organs/Tissues associated with anti-CDCA8 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with CDCA8 and Blood
 Lung Antibodies  >2 publications with CDCA8 and Lung
 Stomach Antibodies  >2 publications with CDCA8 and Stomach
 Uterus Antibodies  >2 publications with CDCA8 and Uterus
 Embryonic Tissue Antibodies  >2 publications with CDCA8 and Embryonic Tissue
 Bone Antibodies  >1 publications with CDCA8 and Bone
 Cervix Antibodies  >1 publications with CDCA8 and Cervix
 Vascular Antibodies  >1 publications with CDCA8 and Vascular
 Bone Marrow Antibodies  >1 publications with CDCA8 and Bone Marrow
 Spleen Antibodies  >1 publications with CDCA8 and Spleen
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