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Spectrin Beta 3 (SPTBN2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS622101

Mutations in spectrins are a previously unknown cause of ataxia and neurodegenerative disease that affect membrane proteins involved in glutamate signaling. Spectrin-beta IIIs have been recognized as ataxia disease genes and their mutations cause… More details

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Product Overview

Online Datasheet in PDF
Product Name
Spectrin Beta 3 (Sptbn2), Polyclonal Antibody
Full Product Name
Spectrin Beta 3 (Beta III Spectrin, KIAA0302, Spectrin beta Chain Brain 2, Spectrin beta Non-erythrocytic 2, Spectrin Non-erythroid beta Chain 2, SPTBN2, Spinocerebellar Ataxia 5, SCA5, SCA 5)
Product Gene Name
anti-Sptbn2 antibody
Product Synonym Names
Anti -Spectrin Beta 3 (Beta III Spectrin, KIAA0302, Spectrin beta Chain Brain 2, Spectrin beta Non-erythrocytic 2, Spectrin Non-erythroid beta Chain 2, SPTBN2, Spinocerebellar Ataxia 5, SCA5, SCA 5)
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Tris-citrate/phosphate buffer, pH 7 to 8
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Species Crossreactivity: This antibody reacts with human. Other species have not been tested.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
271,064 Da
Chromosome Location
Chromosome: 1; NC_005100.3 (226828798..226869726). Location: 1q42
3D Structure
ModBase 3D Structure for Q9QWN8
Immunogen
The epitope recognized by this antibody maps to a region between residues 2150 and 2200 of human spectrin, beta, non-erythrocytic 2 (spinocerebellar ataxia 5) using the numbering given in entry NP_008877.1. Homology: 100% with human, mouse, and rat protein.
Positive Control
HeLa whole cell lysate

Product Categories/Family for anti-Sptbn2 antibody

Antibodies; Abs to Spectrin
Applications Tested/Suitable for anti-Sptbn2 antibody
Immunoprecipitation (IP), Immunohistochemistry (IHC)
Application Notes for anti-Sptbn2 antibody
Suitable for use in Immunoprecipitation and Immunohistochemistry.

Other Notes

Small volumes of anti-Sptbn2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Sptbn2 purchase

MBS622101 is an antibody targeting Sptbn2. Also known as Spectrin Beta 3 (Beta III Spectrin, KIAA0302, Spectrin beta Chain Brain 2, Spectrin beta Non-erythrocytic 2, Spectrin Non-erythroid beta Chain 2, SPTBN2, Spinocerebellar Ataxia 5, SCA5, SCA 5). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Sptbn2. It may not necessarily be applicable to this product.

NCBI GI #
9507135
NCBI GeneID
29211
NCBI Accession #
NP_062040.1
UniProt Primary Accession #
Q9QWN8
UniProt Secondary Accession #
O88197; Q9ES68
UniProt Related Accession #
Q9QWN8
GenBank Nucleotide #
NM_019167.1
NCBI Official Full Name
spectrin beta chain, non-erythrocytic 2
NCBI Official Synonym Full Names
spectrin, beta, non-erythrocytic 2
NCBI Official Symbol
Sptbn2
NCBI Official Synonym Symbols
Spnb3
UniProt Protein Name
Spectrin beta chain, non-erythrocytic 2
UniProt Synonym Protein Names
Beta SpIII sigma 1; Beta-III spectrin; Glutamate transporter EAAT4-associated protein 41; SPNB-3; Spectrin-like protein GTRAP41
Protein Family
Spectrin
UniProt Gene Name
Sptbn2
UniProt Synonym Gene Names
Spnb3
UniProt Entry Name
SPTN2_RAT
NCBI Protein Information
spectrin beta chain, non-erythrocytic 2; SPNB-3; beta-spectrin 3; spectrin beta 3; beta-III spectrin; beta SpIII sigma 1; spectrin beta chain, brain 2; spectrin-like protein GTRAP41; spectrin, non-erythroid beta chain 2; glutamate transporter EAAT4-associated protein 41

NCBI Summary for Sptbn2

may modulate the structural integrity of the Golgi apparatus; binds preferentially to Arp1 rather than actin to mediate the direct interaction of dynein and dynactin with vesicles [RGD, Feb 2006]

UniProt Comments for Sptbn2

SPTBN2: Probably plays an important role in neuronal membrane skeleton. Defects in SPTBN2 are the cause of spinocerebellar ataxia type 5 (SCA5). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA5 is an autosomal dominant cerebellar ataxia (ADCA). It is a slowly progressive disorder with variable age at onset, ranging between 10 and 50 years. Belongs to the spectrin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Cellular Component: spectrin; extracellular space; nuclear matrix; cell soma; apical plasma membrane; cytoplasm; cytosol; cell junction

Molecular Function: structural constituent of cytoskeleton; phospholipid binding; actin binding

Biological Process: vesicle-mediated transport; synaptic vesicle exocytosis; synaptogenesis; actin filament capping; adult behavior; multicellular organism growth; cerebellar Purkinje cell layer morphogenesis; regulation of calcium ion-dependent exocytosis; synaptic vesicle docking during exocytosis
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Research Articles on Sptbn2

1. betaIII spectrin regulates the structural integrity and the secretory protein transport of the Golgi complex

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Sptbn2 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interaction Between L1 And Ankyrins Pathway antibodies  Interaction Between L1 And Ankyrins Pathway Diagram
 L1CAM Interactions Pathway antibodies  L1CAM Interactions Pathway Diagram
 MHC Class II Antigen Presentation Pathway antibodies  MHC Class II Antigen Presentation Pathway Diagram
 NCAM Signaling For Neurite Out-growth Pathway antibodies  NCAM Signaling For Neurite Out-growth Pathway Diagram
 Nephrin Interactions Pathway antibodies  Nephrin Interactions Pathway Diagram

Diseases associated with anti-Sptbn2 antibody

 Disease Name  Pubmed Publications
 Spinocerebellar Ataxias Antibodies  >21 publications with Sptbn2 and Spinocerebellar Ataxias
 Brain Diseases Antibodies  >18 publications with Sptbn2 and Brain Diseases
 Nervous System Diseases Antibodies  >18 publications with Sptbn2 and Nervous System Diseases
 Atrophy Antibodies  >4 publications with Sptbn2 and Atrophy
 Cognition Disorders Antibodies  >1 publications with Sptbn2 and Cognition Disorders

Organs/Tissues associated with anti-Sptbn2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with Sptbn2 and Brain
 Eye Antibodies  >2 publications with Sptbn2 and Eye
 Liver Antibodies  >1 publications with Sptbn2 and Liver
 Prostate Antibodies  >1 publications with Sptbn2 and Prostate
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