CD44 Antibody – Mouse Monoclonal

CD44 is the receptor for hyaluronan. The interaction between CD44 and hyaluronan may mediate binding of cells to basement membranes. Several CD44 isoforms or variants arise from alternative splicing of mRNA transcribed from a single gene located on chromosome 11. Most cell types express the st andard CD44, while the expression of the isoforms resulting from the alternative splicing is of limited distribution. The CD44 st andard form is observed to associate with Src and the Src family members Fyn and Yes. Stimulation of CD44 st andard expressed by SK-OV-3.ipl ovarian cancer cells by the addition of hyaluronan results in recruitment of Src to a CD44-containing complex and increases phosphorylation of Src at tyrosine 418. Phosphorylation at this residue increases Src kinase activity. Cortactin, a cytoskeleton-associated protein and a known substrate for Src, is also phosphorylated in response to CD44 stimulation with hyaluronan and this phosphorylation reduces cortactin's ability to cross-link filamentous actin (Bourguignon et al. 2001).

Small volumes of anti-CD44 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS6221348 is an antibody targeting CD44. Also known as CD44 (HCAM, Homing Cell Adhesion Molecule, Pgp-1, Phagocytic Glycoprotein-1, Hermes Antigen, Lymphocyte Homing Receptor, ECM-III, HUTCH-1) (MaxLight 650). Reactive in Human. Host: Mouse.