Goat Anti-AGTR1 Polyclonal Antibody – Cat# MBS622166

Western blot analysis of AGTR1 in Mouse Liver lysate (35μg protein in RIPA buffer) using AGTR1 antibody (0.3μg/ml).

Angiotensin II Type 1 Receptor (AGTR1) Antibody – Goat Polyclonal

Name: AGTR1 Antibody; Polyclonal; Goat; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS622166
Price: 980 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS622166

Angiotensin II interacts with two types of G-protein coupled membrane receptors, AT1 (type 1) and AT2 (type 2). Major cardiovascular effects appear to be mediated through AT1. AT1 has three isoforms (rat AT1A 359aa; AT1B/AT III, 359aa; and AT1C, 177aa). Rat… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Angiotensin II Type 1 Receptor (AGTR1), Polyclonal Antibody

Full Product Name

Angiotensin II Type 1 Receptor (AGTR1, Angiotensin II Receptor, Type 1, AG2S, AGTR1A, AGTR1B, AT1, AT1B, AT2R1, AT2R1A, AT2R1B, HAT1R, Angiotensin Receptor 1, Angiotensin Receptor 1B, Type-1B Angiotensin II Receptor)

Product Gene Name

anti-AGTR1 antibody

Product Synonym Names

Anti -Angiotensin II Type 1 Receptor (AGTR1, Angiotensin II Receptor, Type 1, AG2S, AGTR1A, AGTR1B, AT1, AT1B, AT2R1, AT2R1A, AT2R1B, HAT1R, Angiotensin Receptor 1, Angiotensin Receptor 1B, Type-1B Angiotensin II Receptor)

Clonality

Polyclonal

Host

Goat

Species Reactivity

Human, Mouse, Rat

Form/Format

Supplied as a liquid in Tris-saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography.

Specificity

Recognizes human AGTR1 at ~38kD in Liver lysates of Human, Mouse and Rat (calculated MW of 41.1kDa according to NP_000676.1, NP_004826.2, NP_033611.1, NP_114038.1 and NP_114438.1). Species Crossreactivity: Mouse and rat.

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

41,046 Da

3D Structure

ModBase 3D Structure for O77590

Immunogen

Synthetic peptide of AGTR1.

Product Categories/Family for anti-AGTR1 antibody

Antibodies; Abs to Receptors

Applications Tested/Suitable for anti-AGTR1 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-AGTR1 antibody

Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:32000
Western Blot: 0.3-1ug/ml

Other Notes

Small volumes of anti-AGTR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AGTR1 purchase

MBS622166 is an antibody targeting AGTR1. Also known as Angiotensin II Type 1 Receptor (AGTR1, Angiotensin II Receptor, Type 1, AG2S, AGTR1A, AGTR1B, AT1, AT1B, AT2R1, AT2R1A, AT2R1B, HAT1R, Angiotensin Receptor 1, Angiotensin Receptor 1B, Type-1B Angiotensin II Receptor). Reactive in Human, Mouse, Rat. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for AGTR1. It may not necessarily be applicable to this product.

NCBI GI #

7650485

NCBI GeneID

443107

UniProt Primary Accession #

O77590

UniProt Related Accession #

O77590

NCBI Official Full Name

angiotensin II type 1 receptor

NCBI Official Symbol

AGTR1

NCBI Official Synonym Symbols

AT1-R

UniProt Protein Name

Type-1 angiotensin II receptor

UniProt Synonym Protein Names

Angiotensin II type-1 receptor

Protein Family

Type-1 angiotensin II receptor

UniProt Gene Name

AGTR1

UniProt Entry Name

AGTR1_SHEEP

NCBI Protein Information

type-1 angiotensin II receptor; AT1; angiotensin II type 1 receptor; angiotensin II type-1 receptor

UniProt Comments for AGTR1

Function: Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subunit structure: Interacts with MAS1

Subcellular location: Cell membrane; Multi-pass membrane protein.

Post-translational modification: Carboxyl-terminal Ser or Thr residues may be phosphorylated.

Sequence similarities: Belongs to the G-protein coupled receptor 1 family.

Research Articles on AGTR1

1. Chronic mild hypoxemia increased binding of angiotensin receptors in brain stem nuclei, decreased spontaneous baroreflex gain, and increased chemoreflex responses to asphyxia in the fetus.
2. replacement of thyroid hormone in hypothyroid sheep fetuses can restore renal ANG II receptor and renin expression and secretion to normal
3. TX decreased both angiotensin II receptor subtype 1 (AT1) mRNA and protein levels in kidney and lung but not in the left ventricle.
4. Angiotensin via the AT1 receptor may mediate, in part, the hypertensive effects of cortisol in utero.
5. pressor and renal vasoconstrictor effects of ANG II during the first 6 weeks of postnatal life in lambs are elicited by activation of AT1 but not AT2 receptors.
6. Immunoreactive AT1 receptor was decreased in the left ventricle of nutrient restricted fetuses compared to control fetuses. AT1 & AT2 message & protein are not tightly coupled, pointing to post-transcriptional control points in the mid gestation NR fetus.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.