Sheep Anti-SERPINA3 Polyclonal Antibody – Cat# MBS622305

Cell lysates were resolved by SDS-PAGE, transferred to an Immobilon-P membrane and immunoblotted with B0002-92E7 (1ug/ml) direct ELISAs and Western blots. In direct ELISAs, this antibody shows less than 1% cross-reactivity with rhX11-α and rhX11-β.

Amyloid Beta A3 Precursor Protein (SERPINA3) Antibody – Sheep Polyclonal

Name: SERPINA3 Antibody; Polyclonal; Sheep; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS622305
Price: 1105 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS622305

X11- (Adaptor protein X11 gamma; also APBA3, Mint3 and X11L2) is a member of the X11 family of adaptor proteins. Unlike X11- and - which are generally neuronal proteins, X11- is widely expressed in all tissues. X11- has many functions, including MT-MMP and… More details

$1105 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Amyloid beta A3 Precursor Protein (SERPINA3), Polyclonal Antibody

Full Product Name

Amyloid beta A3 Precursor Protein (APBA3, X11-gamma, Adaptor protein X11 gamma, Mint3, X11L2)

Product Gene Name

anti-SERPINA3 antibody

Product Synonym Names

Anti -Amyloid beta A3 Precursor Protein (APBA3, X11-, Adaptor protein X11 gamma, Mint3, X11L2)

Clonality

Polyclonal

Isotype

IgG

Host

Sheep

Species Reactivity

Human

Form/Format

Supplied as a lyophilized powder in PBS, 5% trehalose. Reconstitute with 100ul sterile 40-50% glycerol, PBS, 0.02% sodium azide.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography.

Specificity

Recognizes human APBA3.

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute by adding sterile 40-50% glycerol, PBS, 0.02% sodium azide. Aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

47,651 Da

Chromosome Location

Chromosome: 14; NC_000014.8 (95078639..95090395). Location: 14q32.1

OMIM

107280

3D Structure

ModBase 3D Structure for P01011

Immunogen

Recombinant corresponding to aa1-138 of human APBA3 (E. coli).

Positive Control

Cell lysates were resolved by SDS-PAGE, transferred to an Immobilon-P membrane and
immunoblotted with 1ug/ml sheep anti-human APBA3.

Product Categories/Family for anti-SERPINA3 antibody

Antibodies; Abs to Apoptosis

Applications Tested/Suitable for anti-SERPINA3 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-SERPINA3 antibody

Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 0.5-1ug/ml
Western Blot:1ug/ml

Other Notes

Small volumes of anti-SERPINA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SERPINA3 purchase

MBS622305 is an antibody targeting SERPINA3. Also known as Amyloid beta A3 Precursor Protein (APBA3, X11-gamma, Adaptor protein X11 gamma, Mint3, X11L2). Reactive in Human. Host: Sheep.

Additional Details

NCBI/Uniprot data below describe general gene information for SERPINA3. It may not necessarily be applicable to this product.

NCBI GI #

50659080

NCBI GeneID

NCBI Accession #

NP_001076.2

UniProt Primary Accession #

P01011

UniProt Secondary Accession #

Q13703; Q2TU87; Q2TU88; Q59GP9; Q6LBY8; Q6LDT7; Q6NSC9; Q8N177; Q96DW8; Q9UC47; B3KVQ7

UniProt Related Accession #

P01011

GenBank Nucleotide #

NM_001085.4

NCBI Official Full Name

alpha-1-antichymotrypsin

NCBI Official Synonym Full Names

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3

NCBI Official Symbol

SERPINA3

NCBI Official Synonym Symbols

ACT; AACT; GIG24; GIG25

UniProt Protein Name

Alpha-1-antichymotrypsin

UniProt Synonym Protein Names

Cell growth-inhibiting gene 24/25 protein; Serpin A3

Protein Family

Alpha-1-antichymotrypsin

UniProt Gene Name

SERPINA3

UniProt Synonym Gene Names

AACT; ACT

UniProt Entry Name

AACT_HUMAN

NCBI Protein Information

alpha-1-antichymotrypsin; serpin A3; growth-inhibiting protein 24; growth-inhibiting protein 25; cell growth-inhibiting gene 24/25 protein; serine (or cysteine) proteinase inhibitor, clade A, member 3

NCBI Summary for SERPINA3

The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jul 2008]

UniProt Comments for SERPINA3

SERPINA3: Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: extracellular space; extracellular region; intracellular; nucleus

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; DNA binding

Biological Process: regulation of lipid metabolic process; maintenance of gastrointestinal epithelium; acute-phase response; inflammatory response

Research Articles on SERPINA3

1. ACT-17 variation presents a risk factor for Alzheimer's disease in the worldwide population, especially in the Caucasian population.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SERPINA3 antibody

Products by Pathway	Pathway Diagram
Selenium Pathway antibodies	Selenium Pathway Diagram

Diseases associated with anti-SERPINA3 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>14 publications with SERPINA3 and Inflammation
Neoplasms Antibodies	>13 publications with SERPINA3 and Neoplasms
Cardiovascular Diseases Antibodies	>12 publications with SERPINA3 and Cardiovascular Diseases
Mental Disorders Antibodies	>6 publications with SERPINA3 and Mental Disorders
Hypertension Antibodies	>4 publications with SERPINA3 and Hypertension
Necrosis Antibodies	>4 publications with SERPINA3 and Necrosis
Liver Diseases Antibodies	>4 publications with SERPINA3 and Liver Diseases
Heart Diseases Antibodies	>3 publications with SERPINA3 and Heart Diseases
Heart Failure Antibodies	>1 publications with SERPINA3 and Heart Failure
Seizures Antibodies	>1 publications with SERPINA3 and Seizures

Organs/Tissues associated with anti-SERPINA3 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>9 publications with SERPINA3 and Brain
Liver Antibodies	>7 publications with SERPINA3 and Liver
Uterus Antibodies	>4 publications with SERPINA3 and Uterus
Lung Antibodies	>2 publications with SERPINA3 and Lung