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TRAF7 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS622341

MBS622341 is an antibody targeting TRAF7. Also known as TRAF7 (TNF Receptor Associated Factor 7, TNF Receptor-associated Factor 7, TRAF 7, TRAF-7, DKFZp586I021, E3 Ubiquitin Protein Ligase TRAF7, MGC7807, Ring Finger and WD Repeat Domain 1, RFWD1, RING Finger… More details

$760 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TRAF7, Polyclonal Antibody
Full Product Name
TRAF7 (TNF Receptor Associated Factor 7, TNF Receptor-associated Factor 7, TRAF 7, TRAF-7, DKFZp586I021, E3 Ubiquitin Protein Ligase TRAF7, MGC7807, Ring Finger and WD Repeat Domain 1, RFWD1, RING Finger Protein 119, RNF119)
Product Gene Name
anti-TRAF7 antibody
Product Synonym Names
Anti -TRAF7 (TNF Receptor Associated Factor 7, TNF Receptor-associated Factor 7, TRAF 7, TRAF-7, DKFZp586I021, E3 Ubiquitin Protein Ligase TRAF7, MGC7807, Ring Finger and WD Repeat Domain 1, RFWD1, RING Finger Protein 119, RNF119)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Bovine, Human, Mouse, Rat, Xenopus
Form/Format
Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Species Crossreactivity: Crossreacts with Human. Expected to crossreact with Mouse (100% identity with immunogen), Rat, bovine (100% identity with immunogen) and Xenopus laevis (100% identity with immunogen) due to sequence homology. Not yet tested in other species.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 3 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
74,609 Da
Chromosome Location
chromosome: 16; Location: 16p13.3
OMIM
606692
3D Structure
ModBase 3D Structure for Q6Q0C0
Cellular Localization
Colocalizes with MAP3K3 to vesicle like structures throughout the cytoplasm.

Product Categories/Family for anti-TRAF7 antibody

Antibodies; Abs to Transcription Factors; Zinc (Ring) Finger
Applications Tested/Suitable for anti-TRAF7 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-TRAF7 antibody
Suitable for use in ELISA and Western Blot.

Other Notes

Small volumes of anti-TRAF7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TRAF7. It may not necessarily be applicable to this product.

NCBI GI #
45593813
NCBI GeneID
84231
UniProt Primary Accession #
Q6Q0C0
UniProt Secondary Accession #
Q9H073
UniProt Related Accession #
Q6Q0C0
NCBI Official Full Name
TRAF7
NCBI Official Synonym Full Names
TNF receptor-associated factor 7
NCBI Official Symbol
TRAF7
NCBI Official Synonym Symbols
RFWD1; RNF119; MGC7807; DKFZp586I021; TRAF7
UniProt Protein Name
E3 ubiquitin-protein ligase TRAF7
UniProt Synonym Protein Names
RING finger and WD repeat-containing protein 1; RING finger protein 119; TNF receptor-associated factor 7
Protein Family
E3 ubiquitin-protein ligase
UniProt Gene Name
TRAF7
UniProt Synonym Gene Names
RFWD1; RNF119
UniProt Entry Name
TRAF7_HUMAN
NCBI Protein Information
E3 ubiquitin-protein ligase TRAF7; RING finger protein 119; ring finger and WD repeat domain 1; RING finger and WD repeat-containing protein 1

NCBI Summary for TRAF7

Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM]
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UniProt Comments for TRAF7

TRAF7: E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed. Belongs to the WD repeat TRAF7 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; Ubiquitin ligase; Ligase; Ubiquitin conjugating system; EC 6.3.2.19

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: intracellular membrane-bound organelle; perinuclear region of cytoplasm; cytoplasmic membrane-bound vesicle; plasma membrane; nucleus; cytosol; ubiquitin ligase complex

Molecular Function: protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity

Biological Process: positive regulation of protein sumoylation; regulation of protein localization; transcription, DNA-dependent; positive regulation of MAPKKK cascade; apoptosis; activation of MAPKKK activity; protein ubiquitination; negative regulation of transcription from RNA polymerase II promoter
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Research Articles on TRAF7

1. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
2. TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TRAF7 antibody

 Reference Product  PubMed Publications
 TRAF6 antibody  >3 publications with TRAF7 and TRAF6
 CYLD antibody  >2 publications with TRAF7 and CYLD
 MAP3K3 antibody  >1 publications with TRAF7 and MAP3K3

Diseases associated with anti-TRAF7 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >6 publications with TRAF7 and Necrosis
 Inflammation Antibodies  >2 publications with TRAF7 and Inflammation
 Kidney Diseases Antibodies  >1 publications with TRAF7 and Kidney Diseases
 Seizures Antibodies  >1 publications with TRAF7 and Seizures
 Neurodegenerative Diseases Antibodies  >1 publications with TRAF7 and Neurodegenerative Diseases

Organs/Tissues associated with anti-TRAF7 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >1 publications with TRAF7 and Muscle
 Kidney Antibodies  >1 publications with TRAF7 and Kidney
 Ascites Antibodies  >1 publications with TRAF7 and Ascites
 Lung Antibodies  >1 publications with TRAF7 and Lung
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