Mouse Anti-DOC2A Polyclonal Antibody – Cat# MBS622368

Western blot detection of GST tagged recombinant human Doc2-alpha using MBS622368. Note the GST tag alone is 26kD.

Doc2-Alpha (DOC2A) Antibody – Mouse Polyclonal

Name: DOC2A Antibody; Polyclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS622368
Price: 700 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS622368

Doc2-alpha is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release. It may also be involved in dynein-dependent intracellular vesicle transport. The cDNA predicts a 400-amino acid protein with relative mass of… More details

$700 / 0.05 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Doc2-alpha (DOC2A), Polyclonal Antibody

Full Product Name

Doc2-alpha (DOC2A)(Double C2-like domain-containing protein alpha, Doc2)

Product Gene Name

anti-DOC2A antibody

Product Synonym Names

Anti -Doc2-alpha (DOC2A)(Double C2-like domain-containing protein alpha, Doc2)

Clonality

Polyclonal

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in 50% glycerol.

Purity/Purification

Serum
Serum

Specificity

Recognizes human DOC2A.

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

43,959 Da

Chromosome Location

Chromosome: 16; NC_000016.9 (30016835..30022401, complement). Location: 16p11.2

OMIM

604567

3D Structure

ModBase 3D Structure for Q14183

Immunogen

Recombinant human Doc2-alpha (1-400) with a GST tag.

Product Categories/Family for anti-DOC2A antibody

Antibodies; Abs to Neuroscience

Applications Tested/Suitable for anti-DOC2A antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-DOC2A antibody

Suitable for use in ELISA and Western Blot.

Other Notes

Small volumes of anti-DOC2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DOC2A purchase

MBS622368 is an antibody targeting DOC2A. Also known as Doc2-alpha (DOC2A)(Double C2-like domain-containing protein alpha, Doc2). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for DOC2A. It may not necessarily be applicable to this product.

NCBI GI #

47078261

NCBI GeneID

8448

NCBI Accession #

NP_003577.2

UniProt Primary Accession #

Q14183

UniProt Secondary Accession #

Q6P4G4; Q7Z5G0; Q8IVX0

UniProt Related Accession #

Q14183

GenBank Nucleotide #

NM_003586.2

NCBI Official Full Name

double C2-like domain-containing protein alpha

NCBI Official Synonym Full Names

double C2-like domains, alpha

NCBI Official Symbol

DOC2A

NCBI Official Synonym Symbols

Doc2

UniProt Protein Name

Double C2-like domain-containing protein alpha

Protein Family

Double C2-like domain-containing protein

UniProt Gene Name

DOC2A

UniProt Entry Name

DOC2A_HUMAN

NCBI Protein Information

double C2-like domain-containing protein alpha; doc2-alpha; OTTHUMP00000162986

NCBI Summary for DOC2A

There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release. [provided by RefSeq]

UniProt Comments for DOC2A

DOC2A: Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.

Protein type: Adaptor/scaffold; Vesicle

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: neuron projection; synaptic vesicle membrane; lysosome; cell junction

Molecular Function: protein binding; calcium-dependent phospholipid binding; transporter activity

Biological Process: synaptic transmission; nervous system development; synaptic vesicle exocytosis; regulation of calcium ion-dependent exocytosis

Research Articles on DOC2A

1. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DOC2A antibody

Reference Product	PubMed Publications
UNC13B antibody	>6 publications with DOC2A and UNC13B
DYNLT1 antibody	>1 publications with DOC2A and DYNLT1

Diseases associated with anti-DOC2A antibody

Disease Name	Pubmed Publications
Syndrome Antibodies	>1 publications with DOC2A and Syndrome
Seizures Antibodies	>1 publications with DOC2A and Seizures
Nervous System Diseases Antibodies	>1 publications with DOC2A and Nervous System Diseases

Organs/Tissues associated with anti-DOC2A antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>15 publications with DOC2A and Brain
Bone Antibodies	>2 publications with DOC2A and Bone
Embryonic Tissue Antibodies	>1 publications with DOC2A and Embryonic Tissue
Blood Antibodies	>1 publications with DOC2A and Blood