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SH2 Domain Protein 2a (SH2D2A) Antibody – Sheep Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS622587

SH2D2A (SH2 domain-containing protein 2A; also TSAd and VRAP) is a 52kD protein best described as a multifunctional intracellular adaptor molecule. It is expressed in activated CD4+ and CD8+ T cells, endothelial cells, and fibroblasts. SH2D2A is found in both… More details

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Product Overview

Online Datasheet in PDF
Product Name
SH2 domain protein 2A (SH2D2A), Polyclonal Antibody
Full Product Name
SH2 domain protein 2A (SH2D2A, F2771, SCAP, SH2 domain-containing adapter protein, SH2 domain-containing protein 2A, T cell-specific adapter protein, TSAd, TSAD, VEGF receptor-associated protein, VRAP)
Product Gene Name
Product Synonym Names
Anti -SH2 domain protein 2A (SH2D2A, F2771, SCAP, SH2 domain-containing adapter protein, SH2 domain-containing protein 2A, T cell-specific adapter protein, TSAd, TSAD, VEGF receptor-associated protein, VRAP)
Clonality
Polyclonal
Isotype
IgG
Host
Sheep
Species Reactivity
Human
Form/Format
Supplied as a lyophillized power in PBS, 5% Trehalose. Reconstitute with sterile 40-50% glycerol, PBS, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by affinity chromatography.
Specificity
Recognizes endogenous human SH2D2A at 52kD.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile 40-50% glycerol, PBS. Aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
40,951 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (156776035..156786640, complement). Location: 1q21
3D Structure
ModBase 3D Structure for Q5UBZ1
Immunogen
E. coli-derived rhSH2D2A (aa279-389)
Applications Tested/Suitable for anti-SH2D2A antibody
Western Blot (WB)
Application Notes for anti-SH2D2A antibody
Dilution: Western Blot: 0.5ug/ml

Other Notes

Small volumes of anti-SH2D2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SH2D2A purchase

MBS622587 is an antibody targeting SH2D2A. Also known as SH2 domain protein 2A (SH2D2A, F2771, SCAP, SH2 domain-containing adapter protein, SH2 domain-containing protein 2A, T cell-specific adapter protein, TSAd, TSAD, VEGF receptor-associated protein, VRAP). Reactive in Human. Host: Sheep.

Additional Details

NCBI/Uniprot data below describe general gene information for SH2D2A. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
SH2 domain-containing protein 2A isoform 3
NCBI Official Synonym Full Names
SH2 domain containing 2A
NCBI Official Symbol
SH2D2A
NCBI Official Synonym Symbols
SCAP; TSAD; VRAP; F2771
UniProt Protein Name
SH2 domain containing adpater protein 2 transcript variant 2
UniProt Gene Name
SH2D2A
UniProt Entry Name
Q5UBZ1_HUMAN
NCBI Protein Information
SH2 domain-containing protein 2A; OTTHUMP00000038737; OTTHUMP00000038738; SH2 domain protein 2A; VEGF receptor-associated protein; T cell specific adapter protein TSAd; T lymphocyte specific adaptor protein

NCBI Summary for SH2D2A

This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
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UniProt Comments for SH2D2A

TSAd: an adaptor protein that may facilitate and regulate interaction of KDR with effector proteins important to endothelial cell survival and proliferation. May play a role in the CD4-p56- LCK-dependent signal transduction pathway in T cells. Could also play an important role in normal and pathological angiogenesis.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: cytoplasm; cytosol

Molecular Function: protein binding; SH3/SH2 adaptor activity; SH3 domain binding

Biological Process: cell proliferation; positive regulation of signal transduction; angiogenesis; signal transduction; vascular endothelial growth factor receptor signaling pathway; cell differentiation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-SH2D2A antibody

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