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SLIRP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS622706

SLIRP (SRA stem-loop interacting RNA binding protein) is expressed in normal and tumor tissues, but the majority of the endogenous SLIRP resides in the mitochondria. SLIRP may regulate mitochondrial functions and has the potential to shut down estrogen in… More details

$775 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SLIRP, Polyclonal Antibody
Full Product Name
SLIRP (SRA Stem-loop-interacting RNA-binding Protein Mitochondrial, Chromosome 14 Open Reading Frame 156, C14orf156, DC50, PD04872)
Product Gene Name
anti-SLIRP antibody
Product Synonym Names
Anti -SLIRP (SRA Stem-loop-interacting RNA-binding Protein Mitochondrial, Chromosome 14 Open Reading Frame 156, C14orf156, DC50, PD04872)
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Monkey
Form/Format
Supplied as a liquid in Tris-glycine, 150mM sodium chloride, 0.05% sodium azide
Purity/Purification
Affinity Purified
Purified by peptide immunoaffinity chromatography.
Specificity
Recognizes human and monkey SLIRP protein. Does not cross-react with mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
12,349 Da
Chromosome Location
Chromosome: 14; NC_000014.8 (78174425..78183941). Location: 14q24.3
OMIM
610211
3D Structure
ModBase 3D Structure for Q9GZT3
Immunogen
A synthetic peptide made to a C-terminal region of human SLIRP protein. [Entrez-Prot# AAX58600]. Homology: 100% Mk
Cellular Localization
Nuclear

Product Categories/Family for anti-SLIRP antibody

Antibodies; Abs to Mitochondrial Proteins
Applications Tested/Suitable for anti-SLIRP antibody
Western Blot (WB)
Application Notes for anti-SLIRP antibody
Suitable for use in Western Blot.
Dilution: Western Blot: 0.5-2ug/ml. Band at ~12kD corresponding to SLIRP. May see additional bands above 45kD.

Western Blot (WB) of anti-SLIRP antibody

WB analysis for SLIRP in human liver lysate using MBS622706 at 0.6ug/ml.
Rabbit Anti-SLIRP Polyclonal Antibody – Cat# MBS622706

Other Notes

Small volumes of anti-SLIRP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLIRP purchase

MBS622706 is an antibody targeting SLIRP. Also known as SLIRP (SRA Stem-loop-interacting RNA-binding Protein Mitochondrial, Chromosome 14 Open Reading Frame 156, C14orf156, DC50, PD04872). Reactive in Human, Monkey. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SLIRP. It may not necessarily be applicable to this product.

NCBI GI #
13654278
NCBI GeneID
81892
NCBI Accession #
NP_112487.1
UniProt Primary Accession #
Q9GZT3
UniProt Related Accession #
Q9GZT3
GenBank Nucleotide #
NM_031210.4
NCBI Official Full Name
SRA stem-loop-interacting RNA-binding protein, mitochondrial
NCBI Official Synonym Full Names
SRA stem-loop interacting RNA binding protein
NCBI Official Symbol
SLIRP
NCBI Official Synonym Symbols
DC50; PD04872; C14orf156
UniProt Protein Name
SRA stem-loop-interacting RNA-binding protein, mitochondrial
Protein Family
SRA stem-loop-interacting RNA-binding protein
UniProt Gene Name
SLIRP
UniProt Synonym Gene Names
C14orf156
UniProt Entry Name
SLIRP_HUMAN
NCBI Protein Information
SRA stem-loop-interacting RNA-binding protein, mitochondrial

NCBI Summary for SLIRP

Steroid receptor RNA activator (SRA, or SRA1; MIM 603819) is a complex RNA molecule containing multiple stable stem-loop structures that functions in coactivation of nuclear receptors. SLIRP interacts with stem-loop structure-7 of SRA (STR7) and modulates nuclear receptor transactivation (Hatchell et al., 2006 [PubMed 16762838]).[supplied by OMIM]
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UniProt Comments for SLIRP

SLIRP: RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation.

Protein type: RNA-binding; Nuclear receptor co-regulator; Mitochondrial; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: mitochondrion; perinuclear region of cytoplasm; acrosome; nucleus; ribonucleoprotein complex

Molecular Function: nucleotide binding

Biological Process: sperm motility; transcription, DNA-dependent; regulation of transcription, DNA-dependent; single fertilization; spermatid development
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Research Articles on SLIRP

1. Observational study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-SLIRP antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >2 publications with SLIRP and Brain Diseases
 Skin Diseases Antibodies  >1 publications with SLIRP and Skin Diseases

Organs/Tissues associated with anti-SLIRP antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >1 publications with SLIRP and Heart
 Embryonic Tissue Antibodies  >1 publications with SLIRP and Embryonic Tissue
 Muscle Antibodies  >1 publications with SLIRP and Muscle
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