Leptin Receptor (LEPR) Antibody – Rabbit Polyclonal

Obesity, a common nutritional disorder, is associated with diabetes, hypertension, hyperlipidemia, cancer and many other health related problems. At least five genes, Obese (ob), diabetes (db), fat (fat), agouti yellow (Ay), and tubby (tub) have been linked to obesity. Obese gene encodes an adipocyte-tissue derived secreted protein Ob protein/Leptin (146 amino acid, ~16kD) that controls body weight homeostasis. Leptin mediates its effects via the Leptin receptor or Obese receptors (OBR or LEPR) that is expressed in several tissues including hypothalamus. The Ob-R has at least 6 alternatively spliced forms (OBRa-f or LRa-f) that contain a common extracellular domain. The OBRa represents the initially identified mouse Ob-R (short form, 894aa). OBRa, -c, -d, and -f differ in sequence after Lys889 and have short (30-40 aa) cytoplasmic extension Mouse Ob-Rb (long form) displays ~78% homology to the human Ob-R (long form, 1165aa). OBRb has ~300 aa intracellular tail. Expression of Ob-Rb and other forms have been detected in hypothalamus and other tissues. OBRe lacks the transmembrane domain. The soluble Ob-Re is found in adipose tissues, hypothalamus, heart, and testes. Ob-R is abnormally spliced in db/db mice (truncation of cytoplasmic domain) that are important for leptin signaling. Leptin is structurally related to cytokine family and it activates cytokine-like signal transduction by stimulating the JAK-STAT pathway via the OBRb. The absence of functional leptin in ob/ob and the long form OBRb in db/db mice due to abnormal splicing produces severe obesity. The nature of leptin resistance in other obesity models is not clear.

• Tartaglia, LA (1995) Cell 83, 1263-1271; Chen, H (1995) Cell 84, 491-495; Lee, G-H, et al (1996) Nature 379, 632-6352; Cioffi JA et al (1996) Nature Med. 2, 585-589; Takya K et al (1996) BBRC 225, 75-83; Considine,R.V et al (1996) Diabetes 45, 992-994; Considine,R.V et al (1997) BBRC 233, 248-252

Small volumes of anti-LEPR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS622800 is an antibody targeting LEPR. Also known as Anti - Leptin Receptor (OBR, LEPR, B219, Obese Receptor). Reactive in Mouse. Host: Rabbit
Source: Mouse.