Goat Anti-Su(var)205 Polyclonal Antibody – Cat# MBS622871

H2034-51I(2.5ug/ml) staining of paraffin embedded Human Placenta. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Heterochromatin Protein 1, Beta (Su(var)205) Antibody – Goat Polyclonal

Name: Su(var)205 Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS622871
Price: 835 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS622871

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind… More details

$835 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Heterochromatin Protein 1, beta (Su(var)205), Polyclonal Antibody

Full Product Name

Heterochromatin Protein 1, beta (HP1-beta, Chromobox Homolog 1, CBX1, Heterochromatin Protein p25 beta, HP1Hs-beta, M31, Modifier 1 Protein, MOD1, p25beta)

Product Gene Name

anti-Su(var)205 antibody

Product Synonym Names

Anti -Heterochromatin Protein 1, beta (HP1-beta, Chromobox Homolog 1, CBX1, Heterochromatin Protein p25 beta, HP1Hs-beta, M31, Modifier 1 Protein, MOD1, p25beta)

Clonality

Polyclonal

Isotype

IgG

Host

Goat

Species Reactivity

Human

Form/Format

Supplied as a liquid in Tris, pH 7.3, 0.5% BSA, 0.02% sodium azide.

Purity/Purification

Affinity Purified
Purified by affinity chromatography.

Specificity

Recognizes human CBX1 at ~25kD. Species sequence homology: mouse, rat, canine.

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 monthsat -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

23,185 Da

Chromosome Location

Chromosome: 2L; NT_033779.4 (8209626..8211122, complement). Location: 28F2-28F3; 2-31.1 cM

3D Structure

ModBase 3D Structure for P05205

Immunogen

Synthetic peptide, C-QSQKTAHETDKSE, from the internal region of human CBX1.

Positive Control

Lysates of A431, HeLa and HepG2

Product Categories/Family for anti-Su(var)205 antibody

Antibodies; Abs to Chromatin Proteins

Applications Tested/Suitable for anti-Su(var)205 antibody

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

Application Notes for anti-Su(var)205 antibody

Suitable for use in ELISA, Immunohistochemistry and Western Blot.
Dilution: ELISA: 1:32,000
Immunohistochemistry (paraffin): 2-3ug/ml
Western Blot: 0.3-1.0ug/ml
Optimal dilutions to be determined by the researcher

Other Notes

Small volumes of anti-Su(var)205 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Su(var)205 purchase

MBS622871 is an antibody targeting Su(var)205. Also known as Heterochromatin Protein 1, beta (HP1-beta, Chromobox Homolog 1, CBX1, Heterochromatin Protein p25 beta, HP1Hs-beta, M31, Modifier 1 Protein, MOD1, p25beta). Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for Su(var)205. It may not necessarily be applicable to this product.

NCBI GI #

1170337

NCBI GeneID

34119

NCBI Accession #

P05205.2

UniProt Primary Accession #

P05205

UniProt Secondary Accession #

Q9VLR6; A4V0F1; B6UVR4; B6UVS1; B6UVS2; B6UVS3; B6UVT2; B6UVT6; B6UVT7

UniProt Related Accession #

P05205

NCBI Official Full Name

Heterochromatin protein 1

NCBI Official Synonym Full Names

Suppressor of variegation 205

NCBI Official Symbol

Su(var)205

NCBI Official Synonym Symbols

CBX5; CG8409; dHP-1a; dHP1; DmelCG8409; DmHP-1; DmHP1; E(var)29; E(var)29A; FBgn0003607; H3; HP-1; hp1; Hp1; HP1; HP1-VS; hp1a; Hp1a; HP1a; HP1A; HP1alpha; Su(var); Su(var)2-05; Su(var)2-5; Su(Var)2-5; Su(var)2-501; su(var)205; SU(VAR)205; Su(var)29A; Su(

UniProt Protein Name

Heterochromatin protein 1

UniProt Synonym Protein Names

Non-histone chromosomal protein C1A9 antigen

UniProt Gene Name

Su(var)205

UniProt Synonym Gene Names

HP1; HP1

UniProt Entry Name

HP1_DROME

NCBI Protein Information

CG8409 gene product from transcript CG8409-RA; C1A9-nuclear-antigen; CG8409-PA; CG8409-PB; Su(var)2-5; Su(var)205-PA; Su(var)205-PB; heterochromatic protein; heterochromatic protein 1a; heterochromatin protein 1; heterochromatin protein 1A; heterochromatin protein-1; heterochromatin-binding protein; heterochromatin-protein-1; histone protein 1; suppressor of variegation 205

UniProt Comments for Su(var)205

Function: Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.

Subunit structure: Homodimer; probably associates with Su(var)3-9. Interacts with Mcm10. Interacts (via chromoshadow domain) with piwi (via N-terminal region). Ref.8 Ref.9 Ref.10 Ref.11

Subcellular location: Nucleus.

Sequence similarities: Contains 2 chromo domains.

Research Articles on Su(var)205

1. The Drosophila melanogaster CHD1 chromatin remodeling factor modulates global chromosome structure and counteracts HP1a and H3K9me2.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Su(var)205 antibody

Products by Pathway	Pathway Diagram
Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies	Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram

Organs/Tissues associated with anti-Su(var)205 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>2 publications with Su(var)205 and Blood
Head Antibodies	>2 publications with Su(var)205 and Head
Testis Antibodies	>1 publications with Su(var)205 and Testis