Rab6 Antibody – Rabbit Polyclonal

Rab6 is a member of the Ras superfamily of small Rab GTPases implicated in endocytosis (1). The three distinct members of the Rab6 subfamily (Rab6A, Rab6A' and Rab6B) are structurally similar but likely exhibit nonoverlapping functions (2,3). Rab6 is localized to the Golgi (4) and regulates retrograde transport of membrane-bound target proteins from the Golgi apparatus to the endoplasmic reticulum (5-7) or from the Golgi to the endosome during exocytotic transport (8). Rab6 interacts with microtubule motor proteins such as rabkinesin-6 (KIF20A) and dynein/dynactin complexes; Rab6 related transport requires a functionally intact microtubule system (9,10). Rab6 proteins help regulate cytokinesis and cell cycle check point through interactions with Rab6 effector proteins, including the dynein/dynactin protein DCTN1 and the GTPase activating protein RABGAP1 (11,12).

Small volumes of anti-Rab6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS623063 is an antibody targeting Rab6. Reactive in Human, Monkey, Mouse, Rat. Host: Rabbit.