Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL) Antibody – Goat Polyclonal

The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq]

BMAL1: aryl hydrocarbon receptor nuclear translocator-like protein. A circadian regulatory protein and substrate of casein kinase I epsilon. Heterodimers bind to an E-box element (3'-CACGTG-5'), thereby activating transcription of PER1, and possibly of other circadian clock proteins. Seven splice isoforms have been reported.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: transcription factor complex; PML body; nucleus

Molecular Function: signal transducer activity; protein binding; DNA binding; aryl hydrocarbon receptor binding; protein heterodimerization activity; sequence-specific DNA binding; bHLH transcription factor binding; Hsp90 protein binding

Biological Process: circadian rhythm; transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; negative regulation of TOR signaling pathway; regulation of cell cycle; positive regulation of transcription, DNA-dependent; response to redox state; positive regulation of circadian rhythm; negative regulation of fat cell differentiation; signal transduction; regulation of neurogenesis; regulation of transcription, DNA-dependent; protein import into nucleus, translocation; positive regulation of transcription from RNA polymerase II promoter; regulation of protein catabolic process; spermatogenesis; circadian regulation of gene expression; negative regulation of transcription, DNA-dependent; regulation of hair cycle; regulation of insulin secretion