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Paip2a (PAIP2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS623149

The eukaryotic mRNA 3' poly(A) tail interacts with the 5' cap structure to regulate translation of mRNA transcripts (1). The eIF4G translation initiation factor associates with poly(A) binding protein (PABP) to circularize mRNA (1,2). Paip1 is a PABP… More details

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Product Overview

Online Datasheet in PDF
Product Name
Paip2A, Polyclonal Antibody
Full Product Name
Paip2A (PABP Binding Protein 2A)
Product Gene Name
Product Synonym Names
Anti -Paip2A (PABP Binding Protein 2A)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Monkey, Mouse, Rat
Form/Format
Supplied as liquid in10mM sodium HEPES pH 7.5, 150 mM NaCl, 100ug/ml BSA and 50% glycerol.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human Paip2A. Species crossreactivity: mouse, rat, monkey.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
14,984 Da
Chromosome Location
Chromosome: 5; NC_000005.9 (138677519..138705409). Location: 5q31.2
OMIM
605604
3D Structure
ModBase 3D Structure for Q9BPZ3
Immunogen
Synthetic peptide derived from human Paip2A (KLH-coupled).
Applications Tested/Suitable for anti-PAIP2 antibody
Western Blot (WB)
Application Notes for anti-PAIP2 antibody
Suitable for use in Western Blot.
Dilution: Western Blot: 1:1000. Incubate membrane with diluted antibody in 5% w/v BSA, 1X TBS, 0.1%
Tween-20 at 4 degree C with gentle shaking, overnight.

Western Blot (WB) of anti-PAIP2 antibody

Western blot analysis of extracts from mouse testis and human testis using MBS623149.
Rabbit Anti-PAIP2 Polyclonal Antibody – Cat# MBS623149

Other Notes

Small volumes of anti-PAIP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PAIP2 purchase

MBS623149 is an antibody targeting PAIP2. Also known as Paip2A (PABP Binding Protein 2A). Reactive in Human, Monkey, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PAIP2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
polyadenylate-binding protein-interacting protein 2
NCBI Official Synonym Full Names
poly(A) binding protein interacting protein 2
NCBI Official Symbol
PAIP2
NCBI Official Synonym Symbols
PAIP2A
UniProt Protein Name
Polyadenylate-binding protein-interacting protein 2
UniProt Gene Name
PAIP2
UniProt Synonym Gene Names
PAIP2A; PABP-interacting protein 2; PAIP-2
UniProt Entry Name
PAIP2_HUMAN
NCBI Protein Information
polyadenylate-binding protein-interacting protein 2; PAIP-2; PABP-interacting protein 2; PABC1-interacting protein 2; polyA-binding protein-interacting protein 2

UniProt Comments for PAIP2

PAIP2: Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization. Interacts with the second and third RRM domains and C- terminus regions of PABPC1 in a 2:1 stoichiometry. Belongs to the PAIP2 family.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 5q31.2

Cellular Component: cytoplasm

Molecular Function: mRNA binding; protein binding; translation repressor activity

Biological Process: negative regulation of translational initiation; spermatogenesis; memory
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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