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Melanophilin (MLPH) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS623152

Melanophilin is a member of the exophilin subfamily of Rab effector proteins. It forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. Several alternatively spliced transcript variants of this… More details

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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Melanophilin (Mlph), Polyclonal Antibody
Full Product Name
Melanophilin (Mlph, Exophilin 3, Leaden, Ln, Slp Homolog Lacking C2 Domains a, Slac 2a, Synaptotagmin-like Protein 2a)
Product Gene Name
anti-Mlph antibody
Product Synonym Names
Anti -Melanophilin (Mlph, Exophilin 3, Leaden, Ln, Slp Homolog Lacking C2 Domains a, Slac 2a, Synaptotagmin-like Protein 2a)
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
Mouse
Form/Format
Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
Purity/Purification
Affinity Purified
Purified by affinity chromatography.
Specificity
Recognizes mouse Melanophilin. Sequence homology: rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
65,052 Da
Chromosome Location
Chromosome: 1; NC_000067.5 (92811677..92847719). Location: 1 D; 1 59.0 cM
3D Structure
ModBase 3D Structure for Q91V27
Immunogen
Synthetic peptide corresponding to C-ARHIFAKPVMAQQP, from the C Terminus of mouse Melanophilin (NP_443748.2).

Product Categories/Family for anti-Mlph antibody

Antibodies; Abs to Syntaxin; Synaptotagmin; Synaptophysin
Applications Tested/Suitable for anti-Mlph antibody
Western Blot (WB)
Application Notes for anti-Mlph antibody
Suitable for use in ELISA, Western Blot and Immunofluorescence.
Dilution: ELISA: 1:32,000

Testing Data of anti-Mlph antibody

EB05444 staining (0.5ug/ml) of total melanocyte PNS (200ug per lane) of wild-type and leaden (Mlph null) mice. The upper band may be the stacking-spearating gel interface. Data kindly provided by A N Hume, Imperial College.
Goat Anti-MLPH Polyclonal Antibody – Cat# MBS623152

Testing Data of anti-Mlph antibody

Wild-type C57bl6 derived melanocytes were stained with EB05444 (0.5ug/ml) and detected with Alexa568 conjugated donkey anti-sheep second antibodies. Brightfield image shows melanosome distribution. Data kindly provided by A N Hume, Imperial College.
Goat Anti-MLPH Polyclonal Antibody, Testing Data – Cat# MBS623152

Other Notes

Small volumes of anti-Mlph antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Mlph purchase

MBS623152 is an antibody targeting Mlph. Also known as Melanophilin (Mlph, Exophilin 3, Leaden, Ln, Slp Homolog Lacking C2 Domains a, Slac 2a, Synaptotagmin-like Protein 2a). Reactive in Mouse. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for Mlph. It may not necessarily be applicable to this product.

NCBI GI #
87080831
NCBI GeneID
171531
NCBI Accession #
NP_443748.2
UniProt Primary Accession #
Q91V27
UniProt Secondary Accession #
Q3UFV7; Q99N53
UniProt Related Accession #
Q91V27
GenBank Nucleotide #
NM_053015.3
NCBI Official Full Name
melanophilin
NCBI Official Synonym Full Names
melanophilin
NCBI Official Symbol
Mlph
NCBI Official Synonym Symbols
ln; l1Rk3; Slac-2a; AW228792; D1Wsu84e; l(1)-3Rk; 2210418F23Rik; 5031433I09Rik
UniProt Protein Name
Melanophilin
UniProt Synonym Protein Names
Exophilin-3; Leaden protein; Slp homolog lacking C2 domains a; SlaC2-a; Synaptotagmin-like protein 2a
Protein Family
Melanophilin
UniProt Gene Name
Mlph
UniProt Synonym Gene Names
Ln; Slac2a
UniProt Entry Name
MELPH_MOUSE
NCBI Protein Information
melanophilin; slaC2-a; exophilin-3; leaden protein; OTTMUSP00000025451; synaptotagmin-like protein 2a; slp homolog lacking C2 domains a

UniProt Comments for Mlph

MLPH: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. Defects in MLPH are a cause of Griscelli syndrome type 3 (GS3). GS3 is a rare autosomal recessive disorder characterized by pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes, without other clinical manifestations. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Cellular Component: cortical actin cytoskeleton; cell; perinuclear region of cytoplasm; dendrite; melanosome; stress fiber; microtubule organizing center; intracellular; actin cytoskeleton

Molecular Function: microtubule plus-end binding; protein binding; myosin binding; metal ion binding; myosin V binding; actin binding; Rab GTPase binding

Biological Process: intracellular protein transport; pigmentation; melanosome localization; melanocyte differentiation; protein targeting
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Research Articles on Mlph

1. structural basis for the exclusive association of Slac2-a with the Rab27 subfamily.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Mlph antibody

 Reference Product  PubMed Publications
 Rab27a antibody  >44 publications with Mlph and Rab27a
 Myo5a antibody  >27 publications with Mlph and Myo5a
 Rab27b antibody  >5 publications with Mlph and Rab27b

Diseases associated with anti-Mlph antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >5 publications with Mlph and Neoplasms
 Griscelli syndrome type 3 Antibodies  >5 publications with Mlph and Griscelli syndrome type 3
 Inflammation Antibodies  >2 publications with Mlph and Inflammation
 Craniofacial Abnormalities Antibodies  >1 publications with Mlph and Craniofacial Abnormalities
 Cleft Palate Antibodies  >1 publications with Mlph and Cleft Palate
 Congenital Abnormalities Antibodies  >1 publications with Mlph and Congenital Abnormalities
 Blood Coagulation Disorders Antibodies  >1 publications with Mlph and Blood Coagulation Disorders
 Cardiovascular Diseases Antibodies  >1 publications with Mlph and Cardiovascular Diseases
 Hemorrhage Antibodies  >1 publications with Mlph and Hemorrhage
 Lung Neoplasms Antibodies  >1 publications with Mlph and Lung Neoplasms

Organs/Tissues associated with anti-Mlph antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >15 publications with Mlph and Skin
 Lung Antibodies  >7 publications with Mlph and Lung
 Kidney Antibodies  >1 publications with Mlph and Kidney
 Embryonic Tissue Antibodies  >1 publications with Mlph and Embryonic Tissue
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