Phosphoinositide 3 Kinase, P110 Beta (PIK3CB) Antibody – Rabbit Polyclonal

Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al., 1993 [PubMed 8246984]).[supplied by OMIM]

PIK3CB: catalytic subunit of phosphoinositide-3-kinase beta. Catalyzes the production of phosphatidylinositol-3,4,5-triphosphate by phosphorylating phosphatidylinositol (PI), phosphatidylinositol-4-phosphate (PIP) and phosphatidylinositol-4,5-bisphosphate (PIP2). Growth factors and hormones trigger this phosphorylation event, which in turn coordinates cell growth, cell cycle entry, cell migration and cell survival. PTEN reverses this process, and the PI3K signaling pathway is constitutively activated in human cancers that have loss of function of PTEN. Expressed ubiquitously.

Protein type: EC 2.7.1.153; Carbohydrate Metabolism - inositol phosphate; Kinase, lipid; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3q22.3

Cellular Component: plasma membrane; cytosol; nucleus; phosphoinositide 3-kinase complex

Molecular Function: protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; insulin receptor substrate binding; 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4-phosphate 3-kinase activity; ATP binding; phosphoinositide 3-kinase activity

Biological Process: phosphoinositide 3-kinase cascade; nerve growth factor receptor signaling pathway; activation of MAPK activity; regulation of cell-matrix adhesion; signal transduction; chemotaxis; T cell receptor signaling pathway; embryonic cleavage; phosphoinositide phosphorylation; phospholipid metabolic process; positive regulation of autophagy; epidermal growth factor receptor signaling pathway; platelet activation; cell migration; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; phosphatidylinositol biosynthetic process; insulin receptor signaling pathway; autophagy; innate immune response; vascular endothelial growth factor receptor signaling pathway; homophilic cell adhesion; blood coagulation; leukocyte migration; transmembrane receptor protein tyrosine kinase signaling pathway