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Solute Carrier Family 12a1 (SLC12A1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS623220

Slc12a1, a kidney-specific member of the cation chloride co-transporter family SLC12, facilitates transport of sodium, potassium, and chloride ions from the lumen of the renal thick ascending limb into the cell (1, 2). Transport of sodium dilutes the luminal… More details

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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Solute Carrier Family 12a1 (SLC12A1), Polyclonal Antibody
Full Product Name
Solute Carrier Family 12a1 (Slc12a1, sodium/potassium/chloride transporters, member 1, Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2, Kidney-specific Na-K-Cl symporter, MGC93479, Nkcc2, Solute carrier family 12 member 1)
Product Gene Name
anti-SLC12A1 antibody
Product Synonym Names
Anti -Solute Carrier Family 12a1 (Slc12a1, sodium/potassium/chloride transporters, member 1, Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2, Kidney-specific Na-K-Cl symporter, MGC93479, Nkcc2, Solute carrier family 12 member 1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a liquid, 50% glycerol.
Purity/Purification
Serum
Serum
Specificity
Recognizes rat Slc12a1. Species Crossreactivity: Mouse, human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
121,450 Da
Chromosome Location
Chromosome: 15; NC_000015.9 (48498498..48596275). Location: 15q15-q21.1
OMIM
600839
3D Structure
ModBase 3D Structure for Q13621
Immunogen
Synthetic peptide corresponding to aa33-55 of the N-terminal tail of rat Slc12a1 (NP_001073158)

Product Categories/Family for anti-SLC12A1 antibody

Antibodies; Abs to Ion Channel
Applications Tested/Suitable for anti-SLC12A1 antibody
Western Blot (WB)
Application Notes for anti-SLC12A1 antibody
Suitable for use in Western Blot.
Dilution: Western Blot: 1:1000

Other Notes

Small volumes of anti-SLC12A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLC12A1 purchase

MBS623220 is an antibody targeting SLC12A1. Also known as Solute Carrier Family 12a1 (Slc12a1, sodium/potassium/chloride transporters, member 1, Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2, Kidney-specific Na-K-Cl symporter, MGC93479, Nkcc2, Solute carrier family 12 member 1). Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC12A1. It may not necessarily be applicable to this product.

NCBI GI #
296317278
NCBI GeneID
6557
NCBI Accession #
NP_001171761.1
UniProt Primary Accession #
Q13621
UniProt Secondary Accession #
A8JYA2
UniProt Related Accession #
O76029; O76030; Q13621; Q6ZP54; Q8IUN5
GenBank Nucleotide #
NM_001184832.1
NCBI Official Full Name
solute carrier family 12 member 1 isoform F
NCBI Official Synonym Full Names
solute carrier family 12 (sodium/potassium/chloride transporters), member 1
NCBI Official Symbol
SLC12A1
NCBI Official Synonym Symbols
BSC1; NKCC2; MGC48843
UniProt Protein Name
Solute carrier family 12 member 1
UniProt Synonym Protein Names
Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; Kidney-specific Na-K-Cl symporter
Protein Family
Solute carrier family
UniProt Gene Name
SLC12A1
UniProt Synonym Gene Names
NKCC2
UniProt Entry Name
S12A1_HUMAN
NCBI Protein Information
solute carrier family 12 member 1; NKCC2A variant A; OTTHUMP00000162220; Na-K-2Cl cotransporter; kidney-specific Na-K-Cl symporter; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2

NCBI Summary for SLC12A1

This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.
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UniProt Comments for SLC12A1

NKCC2: Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. Kidney specific. Activated by WNK3. Belongs to the SLC12A transporter family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Membrane protein, multi-pass; Membrane protein, integral; Transporter, SLC family

Chromosomal Location of Human Ortholog: 15q15-q21.1

Cellular Component: membrane; apical plasma membrane; integral to membrane; plasma membrane

Molecular Function: sodium:potassium:chloride symporter activity

Biological Process: transport; sodium ion transport; chloride transport; ion transport; kidney development; excretion; transmembrane transport; potassium ion transport; chemical homeostasis

Disease: Bartter Syndrome, Antenatal, Type 1
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Research Articles on SLC12A1

1. Data demonstrate that hypotonic low-chloride conditions that activate the WNK1-SPAK and OSR1 pathway promote phosphorylation of NKCC2 isoforms.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLC12A1 antibody

 Reference Product  PubMed Publications
 STK39 antibody  >1 publications with SLC12A1 and STK39

Pathways associated with anti-SLC12A1 antibody

 Products by Pathway  Pathway Diagram
 Cation-coupled Chloride Cotransporters Pathway antibodies  Cation-coupled Chloride Cotransporters Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway antibodies  Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway Diagram

Diseases associated with anti-SLC12A1 antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >20 publications with SLC12A1 and Kidney Diseases
 Bartter Syndrome Antibodies  >15 publications with SLC12A1 and Bartter Syndrome
 Hypertension Antibodies  >7 publications with SLC12A1 and Hypertension
 Nephrocalcinosis Antibodies  >5 publications with SLC12A1 and Nephrocalcinosis
 Wasting Syndrome Antibodies  >5 publications with SLC12A1 and Wasting Syndrome
 Hearing Loss Antibodies  >2 publications with SLC12A1 and Hearing Loss
 Hypotension Antibodies  >2 publications with SLC12A1 and Hypotension
 Premature Birth Antibodies  >2 publications with SLC12A1 and Premature Birth
 Hypercalciuria Antibodies  >2 publications with SLC12A1 and Hypercalciuria
 Polyuria Antibodies  >2 publications with SLC12A1 and Polyuria

Organs/Tissues associated with anti-SLC12A1 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >20 publications with SLC12A1 and Kidney
 Brain Antibodies  >2 publications with SLC12A1 and Brain
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