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Spectrin, Beta 2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS623232

Mutations in spectrins are a previously unknown cause of ataxia and neurodegenerative disease that affect membrane proteins involved in glutamate signaling. Spectrin-beta IIs have been recognized as ataxia disease genes and their mutations cause… More details

$820 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Spectrin, beta 2, Polyclonal Antibody
Full Product Name
Spectrin, beta 2 (Spectrin beta Chain Brain 2, Spectrin beta Non-erythrocytic 2, SPTBN2, Spectrin Non-erythroid beta Chain 2, Spinocerebellar Ataxia 5, SCA5)
Product Synonym Names
Anti -Spectrin, beta 2 (Spectrin beta Chain Brain 2, Spectrin beta Non-erythrocytic 2, SPTBN2, Spectrin Non-erythroid beta Chain 2, Spinocerebellar Ataxia 5, SCA5)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human Spectrin, beta 2. Species Sequence Homology: Mouse and rat - 100%.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
The epitope recognized by this antibody maps to a region between residues 2150 and 2200 of human spectrin, beta, non-erythrocytic 2 (spinocerebellar ataxia 5) using the numbering given in entry NP_008877.1

Product Categories/Family for anti-Spectrin, beta 2 antibody

Antibodies; Abs to Spectrin
Applications Tested/Suitable for anti-Spectrin, beta 2 antibody
Immunoprecipitation (IP), Immunohistochemistry (IHC)
Application Notes for anti-Spectrin, beta 2 antibody
Dilution: Immunohistochemistry: 2.5-5ug/ml
Immunoprecipitation: 2-5ug/mg lysate

Testing Data of anti-Spectrin, beta 2 antibody

Image: Detection of Spectrin Beta-III in human hepatocytes
Rabbit Anti-Spectrin, Beta 2 Polyclonal Antibody – Cat# MBS623232

Western Blot (WB) of anti-Spectrin, beta 2 antibody

Image: Detection of Human Spectrin Beta III (SPTBN2/SCA5) by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-SPTBN2/SCA5 used for IP at 3 mcg/mg lysate. SPTBN2/SCA5 was also immunoprecipitated by rabbit anti-SPTBN2/SCA5 antibody NB110-58346, which recognizes a downstream epitope. Detection: Chemiluminescence
Rabbit Anti-Spectrin, Beta 2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS623232

Other Notes

Small volumes of anti-Spectrin, beta 2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Spectrin, beta 2 purchase

MBS623232 is an antibody targeting Spectrin, beta 2. Also known as Spectrin, beta 2 (Spectrin beta Chain Brain 2, Spectrin beta Non-erythrocytic 2, SPTBN2, Spectrin Non-erythroid beta Chain 2, Spinocerebellar Ataxia 5, SCA5). Reactive in Human. Host: Rabbit.
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