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ARP2-3 (ACTR3) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS623257

This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both… More details

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Product Overview

Online Datasheet in PDF
Product Name
ARP2-3 (ACTR3), Polyclonal Antibody
Full Product Name
ARP2-3 (Actin Related Protein 2/3 Complex, Subunit 1B, 41kD (ARP2/3 Subunit 1B, ARPC1B, ARC41, p40-ARC, p41-ARC, ARP2/3 Protein Complex Subunit p41)
Product Gene Name
anti-ACTR3 antibody
Product Synonym Names
Anti -ARP2-3 (Actin Related Protein 2/3 Complex, Subunit 1B, 41kD (ARP2/3 Subunit 1B, ARPC1B, ARC41, p40-ARC, p41-ARC, ARP2/3 Protein Complex Subunit p41)
Clonality
Polyclonal
Host
Goat
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a liquid in Tris-saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human ARP2-3 at ~37kD in human liver lysates (calculated MW of 40.9kD according to NP_005711). A minor band of unknown identity was also consistently observed at 28kDa.. Species Crossreactivity: Mouse and rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
47,371 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (114647537..114716167). Location: 2q14.1
OMIM
604222
3D Structure
ModBase 3D Structure for P61158
Immunogen
Synthetic peptide corresponding to human ARP2-3.

Product Categories/Family for anti-ACTR3 antibody

Antibodies; Abs to Actin Related Proteins
Applications Tested/Suitable for anti-ACTR3 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-ACTR3 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:32,000
Western Blot: 2-4 ug/ml

Western Blot (WB) of anti-ACTR3 antibody

Western blot analysis of ARP2-3 in Human Liver lysate (RIPA buffer, 35μg total protein per lane) using ARP2-3 antibody (2μg/ml).
Goat Anti-ACTR3 Polyclonal Antibody – Cat# MBS623257

Other Notes

Small volumes of anti-ACTR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ACTR3 purchase

MBS623257 is an antibody targeting ACTR3. Also known as ARP2-3 (Actin Related Protein 2/3 Complex, Subunit 1B, 41kD (ARP2/3 Subunit 1B, ARPC1B, ARC41, p40-ARC, p41-ARC, ARP2/3 Protein Complex Subunit p41). Reactive in Human, Mouse, Rat. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for ACTR3. It may not necessarily be applicable to this product.

NCBI GI #
5031573
NCBI GeneID
10096
NCBI Accession #
NP_005712.1
UniProt Primary Accession #
P61158
UniProt Secondary Accession #
P32391
UniProt Related Accession #
P61158; Q53QM2; Q59FV6
GenBank Nucleotide #
NM_005721.3
NCBI Official Full Name
actin-related protein 3
NCBI Official Synonym Full Names
ARP3 actin-related protein 3 homolog (yeast)
NCBI Official Symbol
ACTR3
NCBI Official Synonym Symbols
ARP3
UniProt Protein Name
Actin-related protein 3
UniProt Synonym Protein Names
Actin-like protein 3
Protein Family
Arp2/3 complex-activating protein
UniProt Gene Name
ACTR3
UniProt Synonym Gene Names
ARP3
UniProt Entry Name
ARP3_HUMAN
NCBI Protein Information
actin-related protein 3; OTTHUMP00000203980; actin-like protein 3

NCBI Summary for ACTR3

The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. [provided by RefSeq]
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UniProt Comments for ACTR3

Arp3: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis. Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with WHDC1. Belongs to the actin family. ARP3 subfamily.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q14.1

Cellular Component: Golgi membrane; Arp2/3 protein complex; focal adhesion; membrane; hemidesmosome; lamellipodium; excitatory synapse; actin filament; podosome; intercellular junction; cytosol; actin cytoskeleton

Molecular Function: actin filament binding; protein binding; structural constituent of cytoskeleton; ATP binding

Biological Process: positive regulation of filopodium formation; axon guidance; meiotic chromosome movement towards spindle pole; regulation of myosin II filament assembly or disassembly; establishment and/or maintenance of cell polarity; positive regulation of dendrite morphogenesis; cytokinesis after meiosis; response to carbohydrate stimulus; spindle localization; response to antibiotic; asymmetric cell division; ephrin receptor signaling pathway; innate immune response; cell motility
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Research Articles on ACTR3

1. the centrosome transiently recruits Arp2/3 to perform processes such as centrosome separation prior to mitotic entry.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ACTR3 antibody

 Reference Product  PubMed Publications
 ACTR2 antibody  >146 publications with ACTR3 and ACTR2
 CDC42 antibody  >30 publications with ACTR3 and CDC42
 CTTN antibody  >17 publications with ACTR3 and CTTN
 WASF2 antibody  >2 publications with ACTR3 and WASF2
 ARPC5 antibody  >2 publications with ACTR3 and ARPC5
 WASF3 antibody  >1 publications with ACTR3 and WASF3
 ARPC3 antibody  >1 publications with ACTR3 and ARPC3

Pathways associated with anti-ACTR3 antibody

 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 ErbB1 Downstream Signaling Pathway antibodies  ErbB1 Downstream Signaling Pathway Diagram
 RAC1 Signaling Pathway antibodies  RAC1 Signaling Pathway Diagram

Diseases associated with anti-ACTR3 antibody

 Disease Name  Pubmed Publications
 Blood Coagulation Disorders Antibodies  >17 publications with ACTR3 and Blood Coagulation Disorders
 Neoplasm Metastasis Antibodies  >2 publications with ACTR3 and Neoplasm Metastasis
 Carcinoma Antibodies  >2 publications with ACTR3 and Carcinoma
 Congenital Abnormalities Antibodies  >2 publications with ACTR3 and Congenital Abnormalities
 Adenocarcinoma Antibodies  >2 publications with ACTR3 and Adenocarcinoma
 Lung Neoplasms Antibodies  >1 publications with ACTR3 and Lung Neoplasms
 Colorectal Neoplasms Antibodies  >1 publications with ACTR3 and Colorectal Neoplasms
 Bone Diseases, Developmental Antibodies  >1 publications with ACTR3 and Bone Diseases, Developmental
 Female Urogenital Diseases Antibodies  >1 publications with ACTR3 and Female Urogenital Diseases
 Melanoma Antibodies  >1 publications with ACTR3 and Melanoma

Organs/Tissues associated with anti-ACTR3 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >42 publications with ACTR3 and Nerve
 Blood Antibodies  >25 publications with ACTR3 and Blood
 Muscle Antibodies  >14 publications with ACTR3 and Muscle
 Brain Antibodies  >12 publications with ACTR3 and Brain
 Bone Antibodies  >3 publications with ACTR3 and Bone
 Stomach Antibodies  >3 publications with ACTR3 and Stomach
 Thymus Antibodies  >2 publications with ACTR3 and Thymus
 Lung Antibodies  >2 publications with ACTR3 and Lung
 Liver Antibodies  >2 publications with ACTR3 and Liver
 Vascular Antibodies  >2 publications with ACTR3 and Vascular
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