• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

WIPF1 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS623297

This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive… More details

$835 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
WIPF1, Polyclonal Antibody
Full Product Name
WIPF1 (WAS/WASL interacting protein family, Member 1, MGC111041, PRPL-2, PRPL-2 protein, WAS/WASL interacting protein family member 1, WASP-interacting protein, WASPIP, WIP, Wiskott-Aldrich syndrome protein interacting protein, Wiskott-Aldrich syndrome pr
Product Gene Name
anti-WIPF1 antibody
Product Synonym Names
Anti -WIPF1 (WAS/WASL interacting protein family, Member 1, MGC111041, PRPL-2, PRPL-2 protein, WAS/WASL interacting protein family member 1, WASP-interacting protein, WASPIP, WIP, Wiskott-Aldrich syndrome protein interacting protein, Wiskott-Aldrich syndrome pr
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Form/Format
Supplied as a liquid in Tris, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by affinity chromatography.
Specificity
Recognizes human WIPF1 at ~55kD. Species sequence homology: mouse, rat, canine.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 monthsat -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
51,258 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (175424302..175547627, complement). Location: 2q31.1
OMIM
602357
3D Structure
ModBase 3D Structure for O43516
Immunogen
Synthetic peptide, C-KLARNESRSGSNRRE, from the C-Terminus of human WIPF1.
Positive Control
Human Lymph Node, Spleen and Tonsil lysates

Product Categories/Family for anti-WIPF1 antibody

Antibodies; Abs to Disease Markers
Applications Tested/Suitable for anti-WIPF1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-WIPF1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:64,000
Western Blot: 0.03-0.1ug/ml
Optimal dilutions to be determined by the researcher

Other Notes

Small volumes of anti-WIPF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for WIPF1 purchase

MBS623297 is an antibody targeting WIPF1. Also known as WIPF1 (WAS/WASL interacting protein family, Member 1, MGC111041, PRPL-2, PRPL-2 protein, WAS/WASL interacting protein family member 1, WASP-interacting protein, WASPIP, WIP, Wiskott-Aldrich syndrome protein interacting protein, Wiskott-Aldrich syndrome pr. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for WIPF1. It may not necessarily be applicable to this product.

NCBI GI #
38373695
NCBI GeneID
7456
NCBI Accession #
NP_003378.3
UniProt Primary Accession #
O43516
UniProt Secondary Accession #
Q15220; Q53TA9; Q6MZU9; Q9BU37; Q9UNP1; B8ZZM1; D3DPE4
UniProt Related Accession #
O43516; Q2YDC4
GenBank Nucleotide #
NM_003387.4
NCBI Official Full Name
WAS/WASL-interacting protein family member 1
NCBI Official Synonym Full Names
WAS/WASL interacting protein family, member 1
NCBI Official Symbol
WIPF1
NCBI Official Synonym Symbols
WIP; PRPL-2; WASPIP; MGC111041
UniProt Protein Name
WAS/WASL-interacting protein family member 1
UniProt Synonym Protein Names
Protein PRPL-2; Wiskott-Aldrich syndrome protein-interacting protein
Protein Family
WAS/WASL-interacting protein family
UniProt Gene Name
WIPF1
UniProt Synonym Gene Names
WASPIP; WIP
UniProt Entry Name
WIPF1_HUMAN
NCBI Protein Information
WAS/WASL-interacting protein family member 1; protein PRPL-2; OTTHUMP00000163172; OTTHUMP00000163178; OTTHUMP00000205182; OTTHUMP00000205183; OTTHUMP00000205184; WASP-interacting protein; Wiskott-Aldrich syndrome protein interacting protein; wiskott-Aldrich syndrome protein-interacting protein

UniProt Comments for WIPF1

WIPF1: a cytoskeleton-associated protein that interacts with the Wiskott-Aldrich syndrome protein (WASP) in resting cells. Plays an important role in the organization of the actin cytoskeleton. Phosphorylation by PKC-theta following T cell receptor signaling disengages it from WASP, releasing WASP from WIP inhibition. Binds to a region of WASP that is frequently mutated in Wiskott-Aldrich syndrome.

Protein type: Motility/polarity/chemotaxis; Actin-binding

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: ruffle; cytoplasmic membrane-bound vesicle; actin filament; cytosol; actin cytoskeleton

Molecular Function: protein binding; actin binding; profilin binding

Biological Process: actin filament-based movement; actin polymerization and/or depolymerization; innate immune response; protein complex assembly; response to other organism

Disease: Wiskott-aldrich Syndrome 2
Show more

Research Articles on WIPF1

1. The results suggest that some of the mutations in the WH1 domain cause the Wiskott-Aldrich syndrome syndrome in humans by perturbing the WASP-WIP complex formation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-WIPF1 antibody

 Reference Product  PubMed Publications
 PRKCQ antibody  >1 publications with WIPF1 and PRKCQ
 CTTN antibody  >1 publications with WIPF1 and CTTN
 CRKL antibody  >1 publications with WIPF1 and CRKL

Pathways associated with anti-WIPF1 antibody

 Products by Pathway  Pathway Diagram
 Fc-epsilon Receptor I Signaling In Mast Cells Pathway antibodies  Fc-epsilon Receptor I Signaling In Mast Cells Pathway Diagram
 T Cell Receptor Signaling Pathway antibodies  T Cell Receptor Signaling Pathway Diagram

Diseases associated with anti-WIPF1 antibody

 Disease Name  Pubmed Publications
 Blood Coagulation Disorders Antibodies  >24 publications with WIPF1 and Blood Coagulation Disorders
 Genetic Diseases, Inborn Antibodies  >24 publications with WIPF1 and Genetic Diseases, Inborn
 Neoplasms Antibodies  >3 publications with WIPF1 and Neoplasms
 Breast Neoplasms Antibodies  >2 publications with WIPF1 and Breast Neoplasms
 Inflammation Antibodies  >1 publications with WIPF1 and Inflammation
 Leukemia Antibodies  >1 publications with WIPF1 and Leukemia
 Heart Defects, Congenital Antibodies  >1 publications with WIPF1 and Heart Defects, Congenital
 Limb Deformities, Congenital Antibodies  >1 publications with WIPF1 and Limb Deformities, Congenital
 Intestinal Diseases Antibodies  >1 publications with WIPF1 and Intestinal Diseases
 Brain Neoplasms Antibodies  >1 publications with WIPF1 and Brain Neoplasms

Organs/Tissues associated with anti-WIPF1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >18 publications with WIPF1 and Blood
 Nerve Antibodies  >12 publications with WIPF1 and Nerve
 Brain Antibodies  >4 publications with WIPF1 and Brain
 Bone Antibodies  >3 publications with WIPF1 and Bone
 Bone Marrow Antibodies  >2 publications with WIPF1 and Bone Marrow
 Vascular Antibodies  >2 publications with WIPF1 and Vascular
 Testis Antibodies  >1 publications with WIPF1 and Testis
 Lung Antibodies  >1 publications with WIPF1 and Lung
 Spleen Antibodies  >1 publications with WIPF1 and Spleen
 Embryonic Tissue Antibodies  >1 publications with WIPF1 and Embryonic Tissue
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000