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Proopiomelanocortin (POMC) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS623313

This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide… More details

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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Proopiomelanocortin (POMC), Polyclonal Antibody
Full Product Name
Proopiomelanocortin (Pro-opiomelanocortin, POMC, Corticotropin-lipotropin)
Product Gene Name
anti-POMC antibody
Product Synonym Names
Anti -Proopiomelanocortin (Pro-opiomelanocortin, POMC, Corticotropin-lipotropin)
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in Tris, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by affinity chromatography.
Specificity
Recognizes human POMC at ~26kD. Species sequence homology: mouse, rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 monthsat -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
3,459 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (25383722..25391559, complement). Location: 2p23.3
3D Structure
ModBase 3D Structure for Q53WY7
Immunogen
Synthetic peptide, C-NAIIKNAYKKGE, from the C-Terminus of human POMC.
Positive Control
Mouse pituitary cell line NIH3T3 lysates

Product Categories/Family for anti-POMC antibody

Antibodies; Abs to Hormones; Steroids
Applications Tested/Suitable for anti-POMC antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-POMC antibody
Suitable for use in ELISA, Immunohistochemistry and Western Blot.
Dilution: ELISA: 1:32,000
Immunohistochemistry (paraffin): 2-4ug/ml
Western Blot: 0.01-0.03ug/ml
Optimal dilutions to be determined by the researcher

Immunohistochemistry (IHC) of anti-POMC antibody

Immunohistochemistry of paraffin embedded human pituitary gland using MBS623313 (2.5ug/ml). Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Goat Anti-POMC Polyclonal Antibody – Cat# MBS623313

Western Blot (WB) of anti-POMC antibody

Western Blot of NIH 3T3 lysate (35ug protein in RIPA buffer) using P9025-04 (0.1ug/ml). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-POMC Polyclonal Antibody, Western Blot (WB) – Cat# MBS623313

Other Notes

Small volumes of anti-POMC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for POMC purchase

MBS623313 is an antibody targeting POMC. Also known as Proopiomelanocortin (Pro-opiomelanocortin, POMC, Corticotropin-lipotropin). Reactive in Human, Mouse. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for POMC. It may not necessarily be applicable to this product.

NCBI GI #
998476
NCBI GeneID
5443
UniProt Primary Accession #
Q53WY7
UniProt Related Accession #
P01189; Q53T23; Q53WY7; Q5TZZ7; Q6FHC8; Q6LDP0
NCBI Official Full Name
proopiomelanocortin
NCBI Official Synonym Full Names
proopiomelanocortin
NCBI Official Symbol
POMC
NCBI Official Synonym Symbols
LPH; MSH; NPP; POC; ACTH; CLIP
UniProt Protein Name
Proopiomelanocortin
Protein Family
Beta-endorphin
UniProt Gene Name
proopiomelanocortin/ POMC
UniProt Entry Name
Q53WY7_HUMAN
NCBI Protein Information
pro-opiomelanocortin; beta-LPH; beta-MSH; alpha-MSH; gamma-LPH; gamma-MSH; beta-endorphin; met-enkephalin; lipotropin beta; lipotropin gamma; melanotropin beta; OTTHUMP00000119991; OTTHUMP00000200964; OTTHUMP00000200965; OTTHUMP00000200966; melanotropin alpha; melanotropin gamma; pro-ACTH-endorphin; adrenocorticotropin; corticotropin-lipotropin; adrenocorticotropic hormone; proopiomelanocortin preproprotein; beta-melanocyte-stimulating hormone; alpha-melanocyte-stimulating hormone; corticotropin-like intermediary peptide

UniProt Comments for POMC

POMC: ACTH stimulates the adrenal glands to release cortisol. Defects in POMC may be associated with susceptibility to obesity (OBESITY). It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Defects in POMC are the cause of pro-opiomelanocortinin deficiency (POMCD). Affected individuals present early-onset obesity, adrenal insufficiency and red hair. Belongs to the POMC family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: peroxisomal matrix; extracellular space; cytoplasm; extracellular region; peroxisome; secretory granule

Molecular Function: type 3 melanocortin receptor binding; G-protein-coupled receptor binding; type 4 melanocortin receptor binding; hormone activity; receptor binding

Biological Process: generation of precursor metabolites and energy; cellular protein metabolic process; cell-cell signaling; neuropeptide signaling pathway; regulation of blood pressure; peptide hormone processing; regulation of appetite; positive regulation of transcription from RNA polymerase II promoter; negative regulation of tumor necrosis factor production; glucose homeostasis; signal transduction; cellular pigmentation

Disease: Obesity; Proopiomelanocortin Deficiency
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Research Articles on POMC

1. alpha-Melanocyte-stimulating hormone inhibits tumor necrosis factor alpha-stimulated MUC5AC expression in human nasal epithelial cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-POMC antibody

 Reference Product  PubMed Publications
 MC4R antibody  >258 publications with POMC and MC4R
 MC1R antibody  >178 publications with POMC and MC1R
 MC2R antibody  >91 publications with POMC and MC2R
 MC5R antibody  >77 publications with POMC and MC5R
 FGF10 antibody  >2 publications with POMC and FGF10

Pathways associated with anti-POMC antibody

 Products by Pathway  Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Biosynthesis Of Amine And Peptide Hormones Pathway antibodies  Biosynthesis Of Amine And Peptide Hormones Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 G-protein Activation Pathway antibodies  G-protein Activation Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram

Diseases associated with anti-POMC antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >7367 publications with POMC and Nervous System Diseases
 Neoplasms Antibodies  >6297 publications with POMC and Neoplasms
 PROOPIOMELANOCORTIN DEFICIENCY Antibodies  >2156 publications with POMC and PROOPIOMELANOCORTIN DEFICIENCY
 Lung Diseases Antibodies  >1712 publications with POMC and Lung Diseases
 Obesity Antibodies  >1391 publications with POMC and Obesity
 Pain Antibodies  >1266 publications with POMC and Pain
 Carcinoma Antibodies  >1264 publications with POMC and Carcinoma
 Hypertension Antibodies  >1216 publications with POMC and Hypertension
 Congenital Abnormalities Antibodies  >1033 publications with POMC and Congenital Abnormalities
 Kidney Diseases Antibodies  >961 publications with POMC and Kidney Diseases

Organs/Tissues associated with anti-POMC antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >17029 publications with POMC and Brain
 Pituitary Gland Antibodies  >8765 publications with POMC and Pituitary Gland
 Lung Antibodies  >918 publications with POMC and Lung
 Eye Antibodies  >568 publications with POMC and Eye
 Testis Antibodies  >539 publications with POMC and Testis
 Intestine Antibodies  >401 publications with POMC and Intestine
 Placenta Antibodies  >358 publications with POMC and Placenta
 Embryonic Tissue Antibodies  >357 publications with POMC and Embryonic Tissue
 Uterus Antibodies  >236 publications with POMC and Uterus
 Uncharacterized Tissue Antibodies  >2 publications with POMC and Uncharacterized Tissue
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