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LYVE1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS623417

One of the key groups of molecules regulating leukocyte and tumor cell migration is the glycosaminoglycan hyaluronan (HA). In inflammation, the exit of leukocytes across vascular endothelium to the underlying tissues involves interactions with cell surface… More details

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Product Overview

Online Datasheet in PDF
Product Name
LYVE1, Polyclonal Antibody
Full Product Name
LYVE1, NT (Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1, Cell Surface Retention Sequence-binding Protein 1, CRSBP-1, Hyaluronic Acid Receptor, Extracellular Link Domain-containing Protein 1, LYVE-1, CRSBP1, HAR, XLKD1, UNQ230/PRO263)
Product Gene Name
anti-LYVE1 antibody
Product Synonym Names
Anti -LYVE1, NT (Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1, Cell Surface Retention Sequence-binding Protein 1, CRSBP-1, Hyaluronic Acid Receptor, Extracellular Link Domain-containing Protein 1, LYVE-1, CRSBP1, HAR, XLKD1, UNQ230/PRO263)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human XLKD1. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
35,561 Da
Chromosome Location
Chromosome: 15; AC_000172.1 (42678184..42692474). Location: chromosome: 15
3D Structure
ModBase 3D Structure for Q6UC88
Immunogen
Synthetic peptide selected from the N-terminal region of human XLKD1 (KLH).

Product Categories/Family for anti-LYVE1 antibody

Antibodies; Abs to Receptors
Applications Tested/Suitable for anti-LYVE1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-LYVE1 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-LYVE1 antibody

The anti-XLKD1 N-term Pab is used in Western blot to detect XLKD1 in mouse liver tissue lysate.
Rabbit Anti-LYVE1 Polyclonal Antibody – Cat# MBS623417

Immunohistochemistry (IHC) of anti-LYVE1 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the MBS623417, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of MBS623417 for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-LYVE1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS623417

Western Blot (WB) of anti-LYVE1 antibody

XLKD1 Antibody (N-term) western blot analysis in Y79 cell line lysates (35ug/lane).This demonstrates the XLKD1 antibody detected the XLKD1 protein (arrow).
Rabbit Anti-LYVE1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS623417

Western Blot (WB) of anti-LYVE1 antibody

Western blot analysis of XLKD1 (arrow) using rabbit polyclonal XLKD1 Antibody (C61) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the XLKD1 gene.
Rabbit Anti-LYVE1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS623417

Other Notes

Small volumes of anti-LYVE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LYVE1 purchase

MBS623417 is an antibody targeting LYVE1. Also known as LYVE1, NT (Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1, Cell Surface Retention Sequence-binding Protein 1, CRSBP-1, Hyaluronic Acid Receptor, Extracellular Link Domain-containing Protein 1, LYVE-1, CRSBP1, HAR, XLKD1, UNQ230/PRO263). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for LYVE1. It may not necessarily be applicable to this product.

NCBI GI #
147904924
NCBI GeneID
404179
NCBI Accession #
NP_991384.2
UniProt Primary Accession #
Q6UC88
UniProt Related Accession #
Q6UC88
GenBank Nucleotide #
NM_205815.2
NCBI Official Full Name
lymphatic vessel endothelial hyaluronic acid receptor 1
NCBI Official Synonym Full Names
lymphatic vessel endothelial hyaluronan receptor 1
NCBI Official Symbol
LYVE1
NCBI Official Synonym Symbols
XLKD1; LYVE-1; CRSBP-1
UniProt Protein Name
Lymphatic vessel endothelial hyaluronic acid receptor 1
UniProt Synonym Protein Names
Cell surface retention sequence-binding protein 1; CRSBP-1; Extracellular link domain-containing protein 1
Protein Family
Lymphatic vessel endothelial hyaluronic acid receptor
UniProt Gene Name
LYVE1
UniProt Synonym Gene Names
CRSBP1; XLKD1; LYVE-1; CRSBP-1
UniProt Entry Name
LYVE1_BOVIN
NCBI Protein Information
lymphatic vessel endothelial hyaluronic acid receptor 1; extracellular link domain containing 1; lymphatic vessel endothelial HA recptor-1; extracellular link domain-containing protein 1; cell surface retention sequence binding protein-1; cell surface retention sequence-binding protein 1

UniProt Comments for LYVE1

Function: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. Ref.1

Subunit structure: Homodimer; disulfide-linked. Interacts with PDGFB and IGFBP3. Forms a transient ternary complex with PDGFB and PDGFRB in TGN

By similarity. Ref.1

Subcellular location: Membrane; Single-pass membrane protein

Potential. Note: Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface

By similarity.

Post-translational modification: N-glycosylated. Ref.1O-glycosylated. Ref.1

Sequence similarities: Contains 1 Link domain.
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Research Articles on LYVE1

1. CRSBP-1 plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-LYVE1 antibody

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 Hyaluronan Metabolism Pathway antibodies  Hyaluronan Metabolism Pathway Diagram
 Hyaluronan Uptake And Degradation Pathway antibodies  Hyaluronan Uptake And Degradation Pathway Diagram
 MPS I - Hurler Syndrome Pathway antibodies  MPS I - Hurler Syndrome Pathway Diagram
 MPS II - Hunter Syndrome Pathway antibodies  MPS II - Hunter Syndrome Pathway Diagram
 MPS IIIA - Sanfilippo Syndrome A Pathway antibodies  MPS IIIA - Sanfilippo Syndrome A Pathway Diagram
 MPS IIIB - Sanfilippo Syndrome B Pathway antibodies  MPS IIIB - Sanfilippo Syndrome B Pathway Diagram
 MPS IIIC - Sanfilippo Syndrome C Pathway antibodies  MPS IIIC - Sanfilippo Syndrome C Pathway Diagram
 MPS IIID - Sanfilippo Syndrome D Pathway antibodies  MPS IIID - Sanfilippo Syndrome D Pathway Diagram

Organs/Tissues associated with anti-LYVE1 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >29 publications with LYVE1 and Skin
 Liver Antibodies  >14 publications with LYVE1 and Liver
 Muscle Antibodies  >11 publications with LYVE1 and Muscle
 Uterus Antibodies  >7 publications with LYVE1 and Uterus
 Ovary Antibodies  >5 publications with LYVE1 and Ovary
 Intestine Antibodies  >4 publications with LYVE1 and Intestine
 Reticulum Antibodies  >2 publications with LYVE1 and Reticulum
 Kidney Antibodies  >1 publications with LYVE1 and Kidney
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