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ABHD12 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS623471

ABHD12 has 2-arachidonoylglycerol hydrolase activity (By similarity). It may be a regulator of endocannabinoid signaling pathways (By similarity). More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ABHD12, Polyclonal Antibody
Full Product Name
ABHD12, NT (Abhydrolase Domain-containing Protein 12, 2-arachidonoylglycerol Hydrolase, Monoacylglycerol Lipase ABHD12, C20orf22)
Product Gene Name
anti-ABHD12 antibody
Product Synonym Names
Anti -ABHD12, NT (Abhydrolase Domain-containing Protein 12, 2-arachidonoylglycerol Hydrolase, Monoacylglycerol Lipase ABHD12, C20orf22)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human ABHD12.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
45,097 Da
OMIM
612674
3D Structure
ModBase 3D Structure for Q8N2K0
Immunogen
Synthetic peptide selected from the N-terminal region of human ABHD12 (KLH).

Product Categories/Family for anti-ABHD12 antibody

Antibodies; Abs to Enzymes; Lipase
Applications Tested/Suitable for anti-ABHD12 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-ABHD12 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

Western Blot (WB) of anti-ABHD12 antibody

Western blot analysis of ABHD12 Antibody (N-term) in mouse cerebellum tissue lysates (35ug/lane). ABHD12 (arrow) was detected using the purified Pab.
Rabbit Anti-ABHD12 Polyclonal Antibody – Cat# MBS623471

Immunohistochemistry (IHC) of anti-ABHD12 antibody

Formalin-fixed and paraffin-embedded human testis tissue reacted with ABHD12 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-ABHD12 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS623471

Flow Cytometry (FC/FACS) of anti-ABHD12 antibody

ABHD12 Antibody (N-term) flow cytometric analysis of A549 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-ABHD12 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS623471

Other Notes

Small volumes of anti-ABHD12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ABHD12 purchase

MBS623471 is an antibody targeting ABHD12. Also known as ABHD12, NT (Abhydrolase Domain-containing Protein 12, 2-arachidonoylglycerol Hydrolase, Monoacylglycerol Lipase ABHD12, C20orf22). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ABHD12. It may not necessarily be applicable to this product.

NCBI GI #
55958488
UniProt Primary Accession #
Q8N2K0
UniProt Secondary Accession #
Q5T710; Q5T711; Q96CR1; Q9BX05; Q9NPX7; Q9UFV6; A6NED4; A6NJ90; A8K450; B4DE71
NCBI Official Full Name
abhydrolase domain containing 12
UniProt Protein Name
Monoacylglycerol lipase ABHD12
UniProt Synonym Protein Names
2-arachidonoylglycerol hydrolase; Abhydrolase domain-containing protein 12
Protein Family
Monoacylglycerol lipase
UniProt Gene Name
ABHD12
UniProt Synonym Gene Names
C20orf22
UniProt Entry Name
ABD12_HUMAN

UniProt Comments for ABHD12

ABHD12: Has 2-arachidonoylglycerol hydrolase activity. May be a regulator of endocannabinoid signaling pathways. Defects in ABHD12 are the cause of polyneuropathy hearing loss ataxia retinitis pigmentosa and cataract (PHARC). PHARC is a slowly progressive neurologic disorder with a variable phenotype resembling Refsum disease. Clinical features include sensorineural hearing loss, visual problems related to cataracts, retinitis pigmentosa, pes cavus, ataxic and/or spastic gait disturbances with a progressive sensorimotor peripheral neuropathy. Other features include hyporeflexia, hyperreflexia, extensor plantar responses. Belongs to the serine esterase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.1.23; Hydrolase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 20p11.21

Cellular Component: integral to membrane

Molecular Function: acylglycerol lipase activity

Biological Process: phosphatidylserine catabolic process; adult walking behavior; acylglycerol catabolic process

Disease: Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ABHD12 antibody

 Reference Product  PubMed Publications
 FLNA antibody  >12 publications with ABHD12 and FLNA

Pathways associated with anti-ABHD12 antibody

 Products by Pathway  Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram

Diseases associated with anti-ABHD12 antibody

 Disease Name  Pubmed Publications
 Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules Antibodies  >2426 publications with ABHD12 and Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules
 Inflammation Antibodies  >2 publications with ABHD12 and Inflammation
 Central Nervous System Diseases Antibodies  >1 publications with ABHD12 and Central Nervous System Diseases
 Demyelinating Diseases Antibodies  >1 publications with ABHD12 and Demyelinating Diseases
 Refsum Disease Antibodies  >1 publications with ABHD12 and Refsum Disease
 POLYNEUROPATHY, HEARING LOSS, ATAXIA, RETINITIS PIGMENTOSA, AND CATARACT Antibodies  >1 publications with ABHD12 and POLYNEUROPATHY, HEARING LOSS, ATAXIA, RETINITIS PIGMENTOSA, AND CATARACT

Organs/Tissues associated with anti-ABHD12 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with ABHD12 and Brain
 Eye Antibodies  >1 publications with ABHD12 and Eye
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