• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Interleukin 10 Receptor Alpha (IL10RA) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS623629

Interleukin-10 (IL-10) is a cytokine whose main biological function is to suppress the immune response by induction of a signal(s) leading to inhibition of synthesis of a number of cytokines and their cellular receptors. Signal transduction is initiated upon… More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Interleukin 10 Receptor alpha (IL10RA), Polyclonal Antibody
Full Product Name
Interleukin 10 Receptor alpha (IL10RA, IL-10RA, IL-10R-A, CDw210a, HIL-10R, IL-10R1, IL10R)
Product Gene Name
anti-IL10RA antibody
Product Synonym Names
Anti -Interleukin 10 Receptor alpha (IL10RA, IL-10RA, IL-10R-A, CDw210a, HIL-10R, IL-10R1, IL10R)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human IL10RA.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
63,003 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (117857106..117872198). Location: 11q23
OMIM
146933
3D Structure
ModBase 3D Structure for Q13651
Immunogen
Synthetic peptide selected from the Center region of human IL10RA (KLH).

Product Categories/Family for anti-IL10RA antibody

Antibodies; Abs to Interleukin
Applications Tested/Suitable for anti-IL10RA antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-IL10RA antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

Western Blot (WB) of anti-IL10RA antibody

Western Blot analysis in MCF-7 whole cell lysate (20ug) using MBS623629 (1:1000). Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10,000 dilution. Predicted band size: 63kD Blocking/Dilution buffer: 5% NFDM/TBST.
Rabbit Anti-IL10RA Polyclonal Antibody – Cat# MBS623629

Flow Cytometry (FC/FACS) of anti-IL10RA antibody

Flow Cytometry analysis of MCF-7 cells using MBS623629 (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-IL10RA Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS623629

Immunofluorescence (IF) of anti-IL10RA antibody

Confocal immunofluorescent analysis with MCF-7 cell using MBS623629 followed by Alexa Fluor® 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Rabbit Anti-IL10RA Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS623629

Other Notes

Small volumes of anti-IL10RA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL10RA purchase

MBS623629 is an antibody targeting IL10RA. Also known as Interleukin 10 Receptor alpha (IL10RA, IL-10RA, IL-10R-A, CDw210a, HIL-10R, IL-10R1, IL10R). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IL10RA. It may not necessarily be applicable to this product.

NCBI GI #
222136575
NCBI GeneID
3587
NCBI Accession #
NP_001549.2
UniProt Primary Accession #
Q13651
UniProt Secondary Accession #
A8K6I0; B0YJ27
UniProt Related Accession #
Q13651; Q59F35
GenBank Nucleotide #
NM_001558.3
NCBI Official Full Name
interleukin-10 receptor subunit alpha
NCBI Official Synonym Full Names
interleukin 10 receptor, alpha
NCBI Official Symbol
IL10RA
NCBI Official Synonym Symbols
IL10R; CDW210A; HIL-10R; IL-10R1
UniProt Protein Name
Interleukin-10 receptor subunit alpha
UniProt Synonym Protein Names
CDw210a; Interleukin-10 receptor subunit 1
Protein Family
Interleukin-10 receptor
UniProt Gene Name
IL10RA
UniProt Synonym Gene Names
IL10R
UniProt Entry Name
I10R1_HUMAN
NCBI Protein Information
interleukin-10 receptor subunit alpha; IL-10RA; IL-10R subunit 1; OTTHUMP00000233150; IL-10R subunit alpha; IL-10 receptor subunit alpha; interleukin-10 receptor subunit 1; interleukin-10 receptor alpha chain

NCBI Summary for IL10RA

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq]
Show more

UniProt Comments for IL10RA

IL10RA: a receptor for interleukin 10 structurally related to interferon receptors. Mediates the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: plasma membrane; integral to membrane

Molecular Function: protein binding; signal transducer activity; interleukin-10 binding; interleukin-10 receptor activity; receptor activity

Biological Process: cytokine and chemokine mediated signaling pathway; response to lipopolysaccharide

Disease: Inflammatory Bowel Disease 28, Autosomal Recessive
Show more

Research Articles on IL10RA

1. in the Lebanese population, the loss-of-function allele IL-10R1-S138G (SNP3) is unlikely to provide a protective effect against ulcerative colitis and that both IL-10R1 variants do not correlate with inflammatory bowel disease

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IL10RA antibody

 Reference Product  PubMed Publications
 IL10 antibody  >13 publications with IL10RA and IL10
 IL10RB antibody  >4 publications with IL10RA and IL10RB

Pathways associated with anti-IL10RA antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Toxoplasmosis Pathway antibodies  Toxoplasmosis Pathway Diagram
 Toxoplasmosis Pathway antibodies  Toxoplasmosis Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram

Diseases associated with anti-IL10RA antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >8 publications with IL10RA and Inflammation
 Cardiovascular Diseases Antibodies  >3 publications with IL10RA and Cardiovascular Diseases
 Intestinal Diseases Antibodies  >3 publications with IL10RA and Intestinal Diseases
 Dermatitis Antibodies  >2 publications with IL10RA and Dermatitis
 Neoplasms Antibodies  >2 publications with IL10RA and Neoplasms
 Liver Diseases Antibodies  >2 publications with IL10RA and Liver Diseases
 Skin Diseases Antibodies  >2 publications with IL10RA and Skin Diseases
 Colitis Antibodies  >2 publications with IL10RA and Colitis
 Lymphoma Antibodies  >2 publications with IL10RA and Lymphoma
 Coronary Disease Antibodies  >1 publications with IL10RA and Coronary Disease

Organs/Tissues associated with anti-IL10RA antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with IL10RA and Blood
 Skin Antibodies  >2 publications with IL10RA and Skin
 Vascular Antibodies  >2 publications with IL10RA and Vascular
 Bone Antibodies  >1 publications with IL10RA and Bone
 Tonsil Antibodies  >1 publications with IL10RA and Tonsil
 Pharynx Antibodies  >1 publications with IL10RA and Pharynx
 Lung Antibodies  >1 publications with IL10RA and Lung
 Intestine Antibodies  >1 publications with IL10RA and Intestine
 Brain Antibodies  >1 publications with IL10RA and Brain
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000