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Cytokeratin 17 (CK17) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6236332

MBS6236332 is an antibody targeting CK17. Also known as Cytokeratin 17 (Cytokeratin-17, CK 17, CK17, CK-17, Keratin 17, Keratin-17, Keratin Type I Cytoskeletal 17) (MaxLight 750). Reactive in Canine, Goat, Human, Porcine, Rat. Host: Mouse. More details

$980 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Cytokeratin 17 (CK17), Monoclonal Antibody
Full Product Name
Cytokeratin 17 (Cytokeratin-17, CK 17, CK17, CK-17, Keratin 17, Keratin-17, Keratin Type I Cytoskeletal 17) (MaxLight 750)
Product Gene Name
anti-CK17 antibody
Clonality
Monoclonal
Isotype
IgG2b,k
Clone Number
E3, Ks17.E3
Host
Mouse
Species Reactivity
Canine, Goat, Human, Porcine, Rat
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.
Purity/Purification
Purified by Protein G Affinity Chromatography
Specificity
Recognizes rat cytokeratin 17. Species Crossreactivity: human, canine, goat and porcine. Reacts with basal cells in complex epithelia and reacts strongly with SCCs.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
48,106 Da
OMIM
148069
3D Structure
ModBase 3D Structure for Q04695
Immunogen
The cytoskeletal fraction of rat colon epithelium.
Conjugate
MaxLight750
Cellular Localization
Cytoplasmic
Positive Control
Skin

Product Categories/Family for anti-CK17 antibody

Antibodies; Keratin; Cytokeratin
Applications Tested/Suitable for anti-CK17 antibody
Flow Cytometry (FC/FACS), FLISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-CK17 antibody
IP: 1-2ug/500ug protein lysate
IF: 1-2ug/ml
FC/FACS: 0.5-1ug/10e6 cells
Western Blot: 0.5-1ug/ml
Applications are based on unconjugated antibody.

Product References and Citations for anti-CK17 antibody

1. Smedts et al. Am J Pathol 141: 497, 1992. 2. Smedts et al. Am J Pathol 140: 601, 1992. 3. Wetzels et al. Histopathol 20: 295, 1992.

Other Notes

Small volumes of anti-CK17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CK17. It may not necessarily be applicable to this product.

NCBI GI #
4557701
NCBI GeneID
3872
NCBI Accession #
NP_000413
UniProt Primary Accession #
Q04695
UniProt Secondary Accession #
Q6IP98; Q8N1P6; A5Z1M9; A5Z1N0; A5Z1N1; A5Z1N2; A6NDV6; A6NKQ2
UniProt Related Accession #
Q04695
GenBank Nucleotide #
NM_000422.2
NCBI Official Full Name
keratin, type I cytoskeletal 17
NCBI Official Synonym Full Names
keratin 17
NCBI Official Symbol
KRT17
NCBI Official Synonym Symbols
PC; K17; PC2; 39.1; CK-17; PCHC1
UniProt Protein Name
Keratin, type I cytoskeletal 17
UniProt Synonym Protein Names
39.1; Cytokeratin-17; CK-17; Keratin-17
Protein Family
Keratin
UniProt Gene Name
KRT17
UniProt Synonym Gene Names
CK-17; K17
UniProt Entry Name
K1C17_HUMAN
NCBI Protein Information
keratin, type I cytoskeletal 17

NCBI Summary for CK17

This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008]

UniProt Comments for CK17

K17: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K6.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: cytoplasm; intermediate filament

Molecular Function: MHC class II receptor activity; protein binding; structural constituent of cytoskeleton; MHC class II protein binding

Biological Process: positive regulation of hair follicle development; epidermis development; hair follicle morphogenesis; positive regulation of translation; keratinization; intermediate filament organization; signal transduction; positive regulation of cell growth

Disease: Steatocystoma Multiplex; Pachyonychia Congenita 2
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Research Articles on CK17

1. Krt17 was demonstrated to contribute to areca nut-induced oral malignancy

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CK17 antibody

 Reference Product  PubMed Publications
 KRT6A antibody  >17 publications with CK17 and KRT6A
 KRT7 antibody  >1 publications with CK17 and KRT7

Pathways associated with anti-CK17 antibody

 Products by Pathway  Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 Keratinization Pathway antibodies  Keratinization Pathway Diagram

Diseases associated with anti-CK17 antibody

 Disease Name  Pubmed Publications
 Pachyonychia congenita Jackson Lawler type Antibodies  >20 publications with CK17 and Pachyonychia congenita Jackson Lawler type
 Neoplasms Antibodies  >19 publications with CK17 and Neoplasms
 Adenocarcinoma Antibodies  >7 publications with CK17 and Adenocarcinoma
 Carcinoma, Squamous Cell Antibodies  >7 publications with CK17 and Carcinoma, Squamous Cell
 Breast Neoplasms Antibodies  >5 publications with CK17 and Breast Neoplasms
 Pain Antibodies  >4 publications with CK17 and Pain
 Skin Neoplasms Antibodies  >3 publications with CK17 and Skin Neoplasms
 Carcinoma, Basal Cell Antibodies  >2 publications with CK17 and Carcinoma, Basal Cell
 Esophageal Squamous Cell Carcinoma Antibodies  >2 publications with CK17 and Esophageal Squamous Cell Carcinoma
 Precancerous Conditions Antibodies  >1 publications with CK17 and Precancerous Conditions

Organs/Tissues associated with anti-CK17 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >16 publications with CK17 and Skin
 Mouth Antibodies  >3 publications with CK17 and Mouth
 Lymph Antibodies  >2 publications with CK17 and Lymph
 Mammary Gland Antibodies  >2 publications with CK17 and Mammary Gland
 Lymph Node Antibodies  >2 publications with CK17 and Lymph Node
 Intestine Antibodies  >1 publications with CK17 and Intestine
 Bladder Antibodies  >1 publications with CK17 and Bladder
 Prostate Antibodies  >1 publications with CK17 and Prostate
 Muscle Antibodies  >1 publications with CK17 and Muscle
 Pancreas Antibodies  >1 publications with CK17 and Pancreas
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