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PPAP2C Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS623660

PPAP2C is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This… More details

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Product Overview

Online Datasheet in PDF
Product Name
PPAP2C, Polyclonal Antibody
Full Product Name
PPAP2C, CT (Lipid Phosphate Phosphohydrolase 2, Phosphatidic Acid Phosphatase 2c, PAP-2c, PAP2c, Phosphatidate Phosphohydrolase Type 2c, PAP2-gamma, PAP2-G, LPP2)
Product Gene Name
anti-PPAP2C antibody
Product Synonym Names
Anti -PPAP2C, CT (Lipid Phosphate Phosphohydrolase 2, Phosphatidic Acid Phosphatase 2c, PAP-2c, PAP2c, Phosphatidate Phosphohydrolase Type 2c, PAP2-gamma, PAP2-G, LPP2)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human PPAP2C.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
32,574 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (281043..291435, complement). Location: 19p13
OMIM
607126
3D Structure
ModBase 3D Structure for O43688
Immunogen
Synthetic peptide selected from the C-terminal region of human PPAP2C (KLH).

Product Categories/Family for anti-PPAP2C antibody

Antibodies; Abs to Enzymes; Phosphatase
Applications Tested/Suitable for anti-PPAP2C antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-PPAP2C antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-PPAP2C antibody

Western blot analysis of anti-PPAP2C Antibody (C-term) in NCI-H460 cell line lysates (35ug/lane).PPAP2C(arrow) was detected using the purified Pab.
Rabbit Anti-PPAP2C Polyclonal Antibody – Cat# MBS623660

Flow Cytometry (FC/FACS) of anti-PPAP2C antibody

PPAP2C Antibody (C-term) flow cytometric analysis of NCI-H460 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-PPAP2C Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS623660

Other Notes

Small volumes of anti-PPAP2C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PPAP2C purchase

MBS623660 is an antibody targeting PPAP2C. Also known as PPAP2C, CT (Lipid Phosphate Phosphohydrolase 2, Phosphatidic Acid Phosphatase 2c, PAP-2c, PAP2c, Phosphatidate Phosphohydrolase Type 2c, PAP2-gamma, PAP2-G, LPP2). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PPAP2C. It may not necessarily be applicable to this product.

NCBI GI #
12803919
NCBI GeneID
8612
UniProt Primary Accession #
O43688
UniProt Secondary Accession #
A6NLV0
UniProt Related Accession #
O43688; Q59EW5
NCBI Official Full Name
Phosphatidic acid phosphatase type 2C
NCBI Official Synonym Full Names
phosphatidic acid phosphatase type 2C
NCBI Official Symbol
PPAP2C
NCBI Official Synonym Symbols
LPP2; PAP-2c; PAP2-g
UniProt Protein Name
Lipid phosphate phosphohydrolase 2
UniProt Synonym Protein Names
PAP2-gamma; PAP2-G; Phosphatidate phosphohydrolase type 2c; Phosphatidic acid phosphatase 2c
UniProt Gene Name
PPAP2C
UniProt Synonym Gene Names
LPP2
UniProt Entry Name
LPP2_HUMAN
NCBI Protein Information
lipid phosphate phosphohydrolase 2; PAP2c; PAP2-gamma; phosphatidic acid phosphatase 2c; phosphatidate phosphohydrolase type 2c; phosphatidic acid phosphohydrolase type 2c; type-2 phosphatidic acid phosphatase-gamma

NCBI Summary for PPAP2C

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]
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UniProt Comments for PPAP2C

PPAP2C: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P. Belongs to the PA-phosphatase related phosphoesterase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - ether lipid; Lipid Metabolism - sphingolipid; Phosphatase, lipid; Membrane protein, integral; EC 3.1.3.4; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid

Chromosomal Location of Human Ortholog: 19p13

Cellular Component: membrane; integral to membrane; plasma membrane

Molecular Function: phosphatidate phosphatase activity; phosphoprotein phosphatase activity

Biological Process: sphingolipid metabolic process; sphingolipid biosynthetic process; dephosphorylation
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Research Articles on PPAP2C

1. endogenous LPP2 and LPP3 form homo- and hetero-oligomers, which differ in their subcellular localization and which may confer differing spatial regulation of phosphatidic acid and sphingosine 1-phosphate signalling

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PPAP2C antibody

 Products by Pathway  Pathway Diagram
 Ether Lipid Metabolism Pathway antibodies  Ether Lipid Metabolism Pathway Diagram
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 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerophospholipid Metabolism Pathway antibodies  Glycerophospholipid Metabolism Pathway Diagram
 Glycerophospholipid Metabolism Pathway antibodies  Glycerophospholipid Metabolism Pathway Diagram

Diseases associated with anti-PPAP2C antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1 publications with PPAP2C and Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with PPAP2C and Cell Transformation, Neoplastic
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