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Nucleoside Diphosphate Kinase D (NME4) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS623716

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in… More details

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Product Overview

Online Datasheet in PDF
Product Name
Nucleoside Diphosphate Kinase D (NME4), Polyclonal Antibody
Full Product Name
Nucleoside Diphosphate Kinase D, NT (NDPKD, NDPK-D, NM23D, NM23H4, nm23-H4, NME4, Nucleoside Diphosphate Kinase Mitochondrial, NDP Kinase Mitochondrial, NDK)
Product Gene Name
anti-NME4 antibody
Product Synonym Names
Anti -Nucleoside Diphosphate Kinase D, NT (NDPKD, NDPK-D, NM23D, NM23H4, nm23-H4, NME4, Nucleoside Diphosphate Kinase Mitochondrial, NDP Kinase Mitochondrial, NDK)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human NME4.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
20,659 Da
Chromosome Location
Chromosome: 16; NC_000016.9 (446752..450754). Location: 16p13.3
OMIM
601818
3D Structure
ModBase 3D Structure for O00746
Immunogen
Synthetic peptide selected from the C-terminal region of human NME4 (KLH).

Product Categories/Family for anti-NME4 antibody

Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-NME4 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-NME4 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-NME4 antibody

Western Blot analysis of HL-60 cell line lysates (35ug/lane) using MBS623716. NME4 (arrow) was detected using the MBS623716.
Rabbit Anti-NME4 Polyclonal Antibody – Cat# MBS623716

Immunohistochemistry (IHC) of anti-NME4 antibody

Immunohistochemistry analysis in formalin-fixed and paraffin-embedded human cancer tissue using MBS623716, followed by peroxidase conjugation of the secondary antibody and AEC staining. This data demonstrates the use of MBS623716 for immunohistochemistry.
Rabbit Anti-NME4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS623716

Other Notes

Small volumes of anti-NME4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NME4 purchase

MBS623716 is an antibody targeting NME4. Also known as Nucleoside Diphosphate Kinase D, NT (NDPKD, NDPK-D, NM23D, NM23H4, nm23-H4, NME4, Nucleoside Diphosphate Kinase Mitochondrial, NDP Kinase Mitochondrial, NDK). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NME4. It may not necessarily be applicable to this product.

NCBI GI #
4826862
NCBI GeneID
4833
NCBI Accession #
NP_005000.1
UniProt Primary Accession #
O00746
UniProt Secondary Accession #
Q5U0M9
UniProt Related Accession #
O00746
GenBank Nucleotide #
NM_005009.2
NCBI Official Full Name
nucleoside diphosphate kinase, mitochondrial
NCBI Official Synonym Full Names
NME/NM23 nucleoside diphosphate kinase 4
NCBI Official Symbol
NME4
NCBI Official Synonym Symbols
NDPK-D; NM23H4; nm23-H4
UniProt Protein Name
Nucleoside diphosphate kinase, mitochondrial
UniProt Synonym Protein Names
Nucleoside diphosphate kinase D; NDPKD; nm23-H4
UniProt Gene Name
NME4
UniProt Synonym Gene Names
NM23D; NDK; NDP kinase, mitochondrial; NDPKD
UniProt Entry Name
NDKM_HUMAN
NCBI Protein Information
nucleoside diphosphate kinase, mitochondrial; NDK; NDPKD; NDP kinase D; NDP kinase, mitochondrial; nucleoside diphosphate kinase D; non-metastatic cells 4, protein expressed in

NCBI Summary for NME4

The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the nm23 gene family, which includes NME4 (Milon et al., 1997 [PubMed 9099850]).[supplied by OMIM, May 2008]
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UniProt Comments for NME4

NME4: Major role in the synthesis of nucleoside triphosphates other than ATP. Belongs to the NDK family.

Protein type: Nucleotide Metabolism - pyrimidine; Kinase, nucleoside diphosphate; Mitochondrial; EC 2.7.4.6; Kinase, other; Nucleotide Metabolism - purine; Other group; NDK family

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: mitochondrion; mitochondrial inner membrane; mitochondrial intermembrane space; cytosol

Molecular Function: protein binding; metal ion binding; protein complex binding; nucleoside diphosphate kinase activity; ATP binding

Biological Process: GTP biosynthetic process; regulation of apoptosis; CTP biosynthetic process; pyrimidine nucleotide metabolic process; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside and nucleotide interconversion; UTP biosynthetic process; nucleoside triphosphate biosynthetic process; nucleoside metabolic process; nucleoside diphosphate phosphorylation; purine nucleotide metabolic process
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Research Articles on NME4

1. Nm23-H4 acts as a lipid-dependent mitochondrial switch with dual function in phosphotransfer serving local GTP supply and cardiolipin transfer for apoptotic signaling and putative other functions

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-NME4 antibody

 Products by Pathway  Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies  Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
 Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies  Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram

Diseases associated with anti-NME4 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >8 publications with NME4 and Neoplasms
 Carcinoma Antibodies  >5 publications with NME4 and Carcinoma
 Urinary Bladder Neoplasms Antibodies  >1 publications with NME4 and Urinary Bladder Neoplasms
 Nervous System Diseases Antibodies  >1 publications with NME4 and Nervous System Diseases
 Anemia Antibodies  >1 publications with NME4 and Anemia
 Neoplasm Metastasis Antibodies  >1 publications with NME4 and Neoplasm Metastasis
 Cardiomyopathies Antibodies  >1 publications with NME4 and Cardiomyopathies
 Cardiovascular Diseases Antibodies  >1 publications with NME4 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >1 publications with NME4 and Kidney Diseases
 Inflammation Antibodies  >1 publications with NME4 and Inflammation

Organs/Tissues associated with anti-NME4 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3 publications with NME4 and Liver
 Stomach Antibodies  >3 publications with NME4 and Stomach
 Kidney Antibodies  >2 publications with NME4 and Kidney
 Blood Antibodies  >2 publications with NME4 and Blood
 Muscle Antibodies  >2 publications with NME4 and Muscle
 Heart Antibodies  >2 publications with NME4 and Heart
 Ovary Antibodies  >1 publications with NME4 and Ovary
 Intestine Antibodies  >1 publications with NME4 and Intestine
 Embryonic Tissue Antibodies  >1 publications with NME4 and Embryonic Tissue
 Lung Antibodies  >1 publications with NME4 and Lung
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