MAP3K7 Antibody – Rabbit Polyclonal

TAK1: a protein kinase of the MLK family. Mediates signal transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. Also activates MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced isoforms have been reported. Three splice variant isoforms have been described.

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, TKL; EC 2.7.11.25; TKL group; MLK family; TAK1 subfamily

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; intracellular; IkappaB kinase complex; nucleus

Molecular Function: MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; magnesium ion binding; ATP binding; protein kinase activity

Biological Process: positive regulation of JNK activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; activation of MAPKK activity; transcription, DNA-dependent; apoptosis; activation of MAPK activity; MAPKKK cascade; stress-activated MAPK cascade; activation of NF-kappaB-inducing kinase; positive regulation of T cell cytokine production; positive regulation of JNK cascade; protein amino acid phosphorylation; regulation of transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; positive regulation of interleukin-2 production; JNK cascade; angiogenesis; I-kappaB phosphorylation; neural tube formation