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FLIP-L (FAIM3) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS623794

FLICE-inhibitory proteins (FLIP) are widely expressed apoptosis regulator proteins. FLIPs may function as a crucial link between cell survival and cell death pathways in mammalian cells. At least 14 isoforms of FLIP have been defined arising from alternative… More details

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Product Overview

Online Datasheet in PDF
Product Name
FLIP-L (FAIM3), Polyclonal Antibody
Full Product Name
FLIP-L (FLICE-like Inhibitory Protein Long Form, CFLAR, CASH, CASP8AP1, CLARP, MRIT, CASP8 and FADD-like Apoptosis Regulator, Caspase Homolog, CASH, Caspase-eight-related Protein, Casper, Caspase-like Apoptosis Regulatory Protein, CLARP, Cellular FLICE-li
Product Gene Name
anti-FAIM3 antibody
Product Synonym Names
Anti -FLIP-L (FLICE-like Inhibitory Protein Long Form, CFLAR, CASH, CASP8AP1, CLARP, MRIT, CASP8 and FADD-like Apoptosis Regulator, Caspase Homolog, CASH, Caspase-eight-related Protein, Casper, Caspase-like Apoptosis Regulatory Protein, CLARP, Cellular FLICE-li
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide.
Purity/Purification
Purified by Ion exchange chromatography.
Concentration
0.5 mg/mL (lot specific)
Specificity
Recognizes the 55kD FLIPL protein, a FLICE inhibitory protein. Does not recognize FLIPS (FLIP short form).
Preparation and Storage
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Chromosome Location
Chromosome: 1; NC_000001.10 (207076630..207095378, complement). Location: 1q32.1
OMIM
606015
3D Structure
ModBase 3D Structure for O15519
Immunogen
Peptide at C-terminus of FLIP-L
Grade
Highly Purified

Product Categories/Family for anti-FAIM3 antibody

Antibodies; Abs to Apoptosis; Caspase
Applications Tested/Suitable for anti-FAIM3 antibody
Western Blot (WB), Immunohistochemistry-Frozen (IHC-Fr)
Application Notes for anti-FAIM3 antibody
WB: 1:500-1:1000
Optimal dilutions to be determined by the researcher
Other applications not tested

Western Blot (WB) of anti-FAIM3 antibody

Western blot analysis of whole cell lysates from HeLa (H), Jurkat (J) and K562 (K) cell lines using MBS623794.
Rabbit Anti-FAIM3 Polyclonal Antibody – Cat# MBS623794

Immunocytochemistry (ICC) of anti-FAIM3 antibody

Immunocytochemistry analysis of Jurkat cells using MBS623794
Rabbit Anti-FAIM3 Polyclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS623794

Other Notes

Small volumes of anti-FAIM3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FAIM3 purchase

MBS623794 is an antibody targeting FAIM3. Also known as FLIP-L (FLICE-like Inhibitory Protein Long Form, CFLAR, CASH, CASP8AP1, CLARP, MRIT, CASP8 and FADD-like Apoptosis Regulator, Caspase Homolog, CASH, Caspase-eight-related Protein, Casper, Caspase-like Apoptosis Regulatory Protein, CLARP, Cellular FLICE-li. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FAIM3. It may not necessarily be applicable to this product.

NCBI GI #
301069341
NCBI GeneID
9214
NCBI Accession #
NP_001180267.1
UniProt Primary Accession #
O15519
UniProt Secondary Accession #
A8K7J2; B7Z6Z0; D9MWM3
UniProt Related Accession #
O60667
GenBank Nucleotide #
NM_001193338.1
NCBI Official Full Name
fas apoptotic inhibitory molecule 3 isoform c
NCBI Official Synonym Full Names
Fas apoptotic inhibitory molecule 3
NCBI Official Symbol
FAIM3
NCBI Official Synonym Symbols
FCMR; TOSO
UniProt Protein Name
Fas apoptotic inhibitory molecule 3
UniProt Synonym Protein Names
Regulator of Fas-induced apoptosis Toso
UniProt Gene Name
FAIM3
UniProt Synonym Gene Names
TOSO
UniProt Entry Name
FAIM3_HUMAN
NCBI Protein Information
fas apoptotic inhibitory molecule 3; Fc mu receptor; IgM Fc receptor; immunoglobulin mu Fc receptor; regulator of Fas-induced apoptosis Toso

NCBI Summary for FAIM3

Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]

UniProt Comments for FAIM3

FAIM3: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: integral to membrane; extracellular region

Biological Process: immune system process; cellular defense response; negative regulation of apoptosis
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Research Articles on FAIM3

1. Overexpression of TOSO gene is associated with chronic lymphocytic leukemia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FAIM3 antibody

 Reference Product  PubMed Publications
 CD19 antibody  >1 publications with FAIM3 and CD19

Diseases associated with anti-FAIM3 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2 publications with FAIM3 and Neoplasms
 Necrosis Antibodies  >1 publications with FAIM3 and Necrosis

Organs/Tissues associated with anti-FAIM3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with FAIM3 and Blood
 Placenta Antibodies  >1 publications with FAIM3 and Placenta
 Lung Antibodies  >1 publications with FAIM3 and Lung
 Heart Antibodies  >1 publications with FAIM3 and Heart
 Spleen Antibodies  >1 publications with FAIM3 and Spleen
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