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CPT1A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS623908

The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the… More details

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Product Overview

Online Datasheet in PDF
Product Name
CPT1A, Polyclonal Antibody
Full Product Name
CPT1A, CT (Carnitine O-palmitoyltransferase 1, Liver Isoform, CPT1-L, Carnitine O-palmitoyltransferase I, Liver Isoform, CPTI-L, CPT I, Carnitine Palmitoyltransferase 1A, CPT1)
Product Gene Name
anti-CPT1A antibody
Product Synonym Names
Anti -CPT1A, CT (Carnitine O-palmitoyltransferase 1, Liver Isoform, CPT1-L, Carnitine O-palmitoyltransferase I, Liver Isoform, CPTI-L, CPT I, Carnitine Palmitoyltransferase 1A, CPT1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human CPT1A.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
88,368 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (68522088..68611878, complement). Location: 11q13.2
OMIM
255120
3D Structure
ModBase 3D Structure for P50416
Immunogen
Synthetic peptide selected from the C-terminal region of human CPT1A (KLH).

Product Categories/Family for anti-CPT1A antibody

Antibodies; Abs to Enzymes;  Transferase
Applications Tested/Suitable for anti-CPT1A antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-CPT1A antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

Western Blot (WB) of anti-CPT1A antibody

Western Blot analysis of Y79 cell line lysate (35ug/lane) using MBS623908. This demonstrates that MBS623908 detected the CPT1A protein (arrow).
Rabbit Anti-CPT1A Polyclonal Antibody – Cat# MBS623908

Immunohistochemistry (IHC) of anti-CPT1A antibody

Left image is paraformaldehyde-fixed and paraffin-embedded cow lactating with MBS623908, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining, right image is contrast, did not add MBS623908. This data was kindly offered by Hideaki Hayashi, University of Bern, Switzerland.
Rabbit Anti-CPT1A Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS623908

Other Notes

Small volumes of anti-CPT1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CPT1A purchase

MBS623908 is an antibody targeting CPT1A. Also known as CPT1A, CT (Carnitine O-palmitoyltransferase 1, Liver Isoform, CPT1-L, Carnitine O-palmitoyltransferase I, Liver Isoform, CPTI-L, CPT I, Carnitine Palmitoyltransferase 1A, CPT1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CPT1A. It may not necessarily be applicable to this product.

NCBI GI #
73623030
NCBI GeneID
1374
NCBI Accession #
NP_001867.2
UniProt Primary Accession #
P50416
UniProt Secondary Accession #
Q8TCU0; Q9BWK0
UniProt Related Accession #
P50416
GenBank Nucleotide #
NM_001876.3
NCBI Official Full Name
carnitine O-palmitoyltransferase 1, liver isoform isoform 1
NCBI Official Synonym Full Names
carnitine palmitoyltransferase 1A (liver)
NCBI Official Symbol
CPT1A
NCBI Official Synonym Symbols
CPT1; CPT1-L; L-CPT1
UniProt Protein Name
Carnitine O-palmitoyltransferase 1, liver isoform
UniProt Synonym Protein Names
Carnitine O-palmitoyltransferase I, liver isoform; CPT I; CPTI-L; Carnitine palmitoyltransferase 1A
Protein Family
Carnitine O-palmitoyltransferase
UniProt Gene Name
CPT1A
UniProt Synonym Gene Names
CPT1; CPT1-L; CPT I; CPTI-L
UniProt Entry Name
CPT1A_HUMAN
NCBI Protein Information
carnitine O-palmitoyltransferase 1, liver isoform; CPT I; CPTI-L; carnitine palmitoyltransferase I, liver; carnitine O-palmitoyltransferase I, liver isoform

NCBI Summary for CPT1A

The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for CPT1A

CPT1A: Belongs to the carnitine/choline acetyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; EC 2.3.1.21; Mitochondrial; Membrane protein, integral; Membrane protein, multi-pass; Lipid Metabolism - fatty acid

Chromosomal Location of Human Ortholog: 11q13.2

Cellular Component: mitochondrial outer membrane; membrane; mitochondrion; mitochondrial inner membrane; integral to mitochondrial outer membrane

Molecular Function: identical protein binding; carnitine O-palmitoyltransferase activity

Biological Process: circadian rhythm; response to drug; eating behavior; glucose metabolic process; long-chain fatty acid metabolic process; carnitine shuttle; cellular lipid metabolic process; response to organic cyclic substance; positive regulation of fatty acid beta-oxidation; fatty acid beta-oxidation; triacylglycerol metabolic process; epithelial cell differentiation; carnitine metabolic process; regulation of insulin secretion; protein homooligomerization

Disease: Carnitine Palmitoyltransferase I Deficiency
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Research Articles on CPT1A

1. Exposure to all-trans RA (ATRA) up-regulated the expression of carnitine palmitoyl transferase-1 (CPT1-L) in HepG2 cells in a dose- and time-dependent manner.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CPT1A antibody

 Reference Product  PubMed Publications
 ACOX1 antibody  >11 publications with CPT1A and ACOX1
 ACADVL antibody  >7 publications with CPT1A and ACADVL
 PPARA antibody  >7 publications with CPT1A and PPARA
 ACSL1 antibody  >6 publications with CPT1A and ACSL1
 PPARGC1A antibody  >5 publications with CPT1A and PPARGC1A
 ACADM antibody  >3 publications with CPT1A and ACADM
 ACADL antibody  >2 publications with CPT1A and ACADL
 ACACB antibody  >1 publications with CPT1A and ACACB

Pathways associated with anti-CPT1A antibody

 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Fatty Acid Beta Oxidation Pathway antibodies  Fatty Acid Beta Oxidation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Import Of Palmitoyl-CoA Into The Mitochondrial Matrix Pathway antibodies  Import Of Palmitoyl-CoA Into The Mitochondrial Matrix Pathway Diagram

Diseases associated with anti-CPT1A antibody

 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >71 publications with CPT1A and Fatty Liver
 Liver Diseases Antibodies  >31 publications with CPT1A and Liver Diseases
 Insulin Resistance Antibodies  >23 publications with CPT1A and Insulin Resistance
 Inflammation Antibodies  >11 publications with CPT1A and Inflammation
 Atherosclerosis Antibodies  >6 publications with CPT1A and Atherosclerosis
 Hepatitis Antibodies  >6 publications with CPT1A and Hepatitis
 Liver Neoplasms Antibodies  >6 publications with CPT1A and Liver Neoplasms
 Diabetes Mellitus Antibodies  >6 publications with CPT1A and Diabetes Mellitus
 Weight Gain Antibodies  >5 publications with CPT1A and Weight Gain
 Carcinoma, Hepatocellular Antibodies  >5 publications with CPT1A and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-CPT1A antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >91 publications with CPT1A and Liver
 Blood Antibodies  >42 publications with CPT1A and Blood
 Muscle Antibodies  >31 publications with CPT1A and Muscle
 Brain Antibodies  >13 publications with CPT1A and Brain
 Kidney Antibodies  >8 publications with CPT1A and Kidney
 Pancreas Antibodies  >5 publications with CPT1A and Pancreas
 Connective Tissue Antibodies  >5 publications with CPT1A and Connective Tissue
 Thyroid Antibodies  >4 publications with CPT1A and Thyroid
 Vascular Antibodies  >3 publications with CPT1A and Vascular
 Bone Antibodies  >3 publications with CPT1A and Bone
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