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SUV420H2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS623966

SUV420H2 is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. The protein mainly functions in pericentric heterochromatin… More details

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Product Overview

Online Datasheet in PDF
Product Name
SUV420H2, Polyclonal Antibody
Full Product Name
SUV420H2, ID (Histone-lysine N-methyltransferase SUV420H2, Suppressor of Variegation 4-20 Homolog 2, Su(var)4-20 Homolog 2, Suv4-20h2, Lysine N-methyltransferase 5C, PP7130, KMT5C)
Product Gene Name
anti-SUV420H2 antibody
Product Synonym Names
Anti -SUV420H2, ID (Histone-lysine N-methyltransferase SUV420H2, Suppressor of Variegation 4-20 Homolog 2, Su(var)4-20 Homolog 2, Suv4-20h2, Lysine N-methyltransferase 5C, PP7130, KMT5C)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human SUV420H2. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
52,113 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (55851221..55859489). Location: 19q13.42
OMIM
613198
3D Structure
ModBase 3D Structure for Q86Y97
Immunogen
Synthetic peptide selected from the Center region of human SUV420H2 (KLH).

Product Categories/Family for anti-SUV420H2 antibody

Antibodies; Abs to Enzymes; Methyltransferase
Applications Tested/Suitable for anti-SUV420H2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-SUV420H2 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-SUV420H2 antibody

Western blot analysis of SUV4-20H2 antibody (Center) in mouse stomach tissue lysates (35ug/lane). SUV4-20H2 (arrow) was detected using the purified Pab.
Rabbit Anti-SUV420H2 Polyclonal Antibody – Cat# MBS623966

Flow Cytometry (FC/FACS) of anti-SUV420H2 antibody

SUV4-20H2 Antibody (Center) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-SUV420H2 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS623966

Other Notes

Small volumes of anti-SUV420H2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SUV420H2 purchase

MBS623966 is an antibody targeting SUV420H2. Also known as SUV420H2, ID (Histone-lysine N-methyltransferase SUV420H2, Suppressor of Variegation 4-20 Homolog 2, Su(var)4-20 Homolog 2, Suv4-20h2, Lysine N-methyltransferase 5C, PP7130, KMT5C). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SUV420H2. It may not necessarily be applicable to this product.

NCBI GI #
17939508
NCBI GeneID
84787
UniProt Primary Accession #
Q86Y97
UniProt Secondary Accession #
Q8WZ10; Q9BRZ6
UniProt Related Accession #
Q86Y97
NCBI Official Full Name
SUV420H2 protein
NCBI Official Synonym Full Names
suppressor of variegation 4-20 homolog 2 (Drosophila)
NCBI Official Symbol
SUV420H2
NCBI Official Synonym Symbols
KMT5C; MGC2705; FLJ51466; FLJ98627
UniProt Protein Name
Histone-lysine N-methyltransferase SUV420H2
UniProt Synonym Protein Names
Lysine N-methyltransferase 5C; Suppressor of variegation 4-20 homolog 2
UniProt Gene Name
SUV420H2
UniProt Synonym Gene Names
KMT5C
UniProt Entry Name
SV422_HUMAN
NCBI Protein Information
histone-lysine N-methyltransferase SUV420H2; suv4-20h2; OTTHUMP00000197477; su(var)4-20 homolog 2; lysine N-methyltransferase 5C

NCBI Summary for SUV420H2

SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 [PubMed 15145825]).[supplied by OMIM]

UniProt Comments for SUV420H2

SUV420H2: Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). Belongs to the histone-lysine methyltransferase family. Suvar4-20 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Methyltransferase; EC 2.1.1.43; Amino Acid Metabolism - lysine degradation; Methyltransferase, protein lysine

Chromosomal Location of Human Ortholog: 19q13.42

Cellular Component: nucleoplasm; centric heterochromatin; nuclear heterochromatin; condensed nuclear chromosome, pericentric region

Molecular Function: protein binding; histone lysine N-methyltransferase activity (H4-K20 specific)

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent
Show more

Research Articles on SUV420H2

1. SUV420H1 and SUV420H2 isoforms have different in their cellular localization and effects on myogenic differentiation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SUV420H2 antibody

 Products by Pathway  Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram

Diseases associated with anti-SUV420H2 antibody

 Disease Name  Pubmed Publications
 Hyperglycemia Antibodies  >1 publications with SUV420H2 and Hyperglycemia

Organs/Tissues associated with anti-SUV420H2 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >1 publications with SUV420H2 and Eye
 Muscle Antibodies  >1 publications with SUV420H2 and Muscle
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