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PIP5K1B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS624028

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in… More details

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Product Overview

Online Datasheet in PDF
Product Name
PIP5K1B, Polyclonal Antibody
Full Product Name
PIP5K1B, NT (Phosphatidylinositol-4-phosphate 5-kinase Type-1 beta, PIP5K1-beta, PtdIns(4)P-5-kinase 1 beta, Phosphatidylinositol-4-phosphate 5-kinase Type I beta, PIP5KIbeta, Protein STM-7, Type I Phosphatidylinositol-4-phosphate 5-kinase beta, STM7)
Product Gene Name
anti-PIP5K1B antibody
Product Synonym Names
Anti -PIP5K1B, NT (Phosphatidylinositol-4-phosphate 5-kinase Type-1 beta, PIP5K1-beta, PtdIns(4)P-5-kinase 1 beta, Phosphatidylinositol-4-phosphate 5-kinase Type I beta, PIP5KIbeta, Protein STM-7, Type I Phosphatidylinositol-4-phosphate 5-kinase beta, STM7)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human PIP5K1B.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
61,036 Da
Chromosome Location
Chromosome: 9; NC_000009.11 (71320616..71624091). Location: 9q13
OMIM
602745
3D Structure
ModBase 3D Structure for O14986
Immunogen
Synthetic peptide selected from the N-terminal region of human PIP5K1B (KLH).

Product Categories/Family for anti-PIP5K1B antibody

Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-PIP5K1B antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PIP5K1B antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-PIP5K1B antibody

Western blot analysis of anti-PIP5K1B Pab in human placenta cell lysate. PIP5K1B (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Rabbit Anti-PIP5K1B Polyclonal Antibody – Cat# MBS624028

Immunohistochemistry (IHC) of anti-PIP5K1B antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with PIP5K1B antibody (N-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-PIP5K1B Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS624028

Other Notes

Small volumes of anti-PIP5K1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PIP5K1B purchase

MBS624028 is an antibody targeting PIP5K1B. Also known as PIP5K1B, NT (Phosphatidylinositol-4-phosphate 5-kinase Type-1 beta, PIP5K1-beta, PtdIns(4)P-5-kinase 1 beta, Phosphatidylinositol-4-phosphate 5-kinase Type I beta, PIP5KIbeta, Protein STM-7, Type I Phosphatidylinositol-4-phosphate 5-kinase beta, STM7). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PIP5K1B. It may not necessarily be applicable to this product.

NCBI GI #
55958860
NCBI GeneID
8395
UniProt Primary Accession #
O14986
UniProt Secondary Accession #
P78518; P78519; Q5T5K6; Q5T5K8; Q5T5K9; Q5VZ00; Q7KYT5; Q8NHQ5; Q92749; A8K9L9
UniProt Related Accession #
O14986; Q7KYT4; Q7KYT6
NCBI Official Full Name
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
NCBI Official Synonym Full Names
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
NCBI Official Symbol
PIP5K1B
NCBI Official Synonym Symbols
MSS4; STM7
UniProt Protein Name
Phosphatidylinositol-4-phosphate 5-kinase type-1 beta
UniProt Synonym Protein Names
Phosphatidylinositol-4-phosphate 5-kinase type I beta; PIP5KIbeta; Protein STM-7; Type I phosphatidylinositol-4-phosphate 5-kinase beta
Protein Family
Phosphatidylinositol 4-phosphate 5-kinase
UniProt Gene Name
PIP5K1B
UniProt Synonym Gene Names
STM7
UniProt Entry Name
PI51B_HUMAN
NCBI Protein Information
phosphatidylinositol-4-phosphate 5-kinase type-1 beta; PIP5KIbeta; PIP5K1-beta; protein STM-7; OTTHUMP00000021423; OTTHUMP00000021424; ptdIns(4)P-5-kinase 1 beta; type I phosphatidylinositol-4-phosphate 5-kinase beta

UniProt Comments for PIP5K1B

PIP5K1B: Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.1.68; Kinase, lipid; Carbohydrate Metabolism - inositol phosphate

Chromosomal Location of Human Ortholog: 9q13

Cellular Component: membrane; endomembrane system; uropod; cytosol

Molecular Function: protein binding; 1-phosphatidylinositol-4-phosphate 5-kinase activity; ATP binding

Biological Process: phosphoinositide phosphorylation; phospholipid metabolic process; phosphatidylinositol biosynthetic process
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Research Articles on PIP5K1B

1. Results identify PIPKIbeta as a novel regulator of focal adhesion disassembly and suggest that PIPKIbeta spatially regulates beta1 integrin endocytosis at adhesion sites to control cell migration.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PIP5K1B antibody

 Products by Pathway  Pathway Diagram
 3-phosphoinositide Biosynthesis Pathway antibodies  3-phosphoinositide Biosynthesis Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Canonical Wnt Signaling Pathway antibodies  Canonical Wnt Signaling Pathway Diagram
 D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram

Diseases associated with anti-PIP5K1B antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >3 publications with PIP5K1B and Kidney Diseases
 Lymphoma Antibodies  >1 publications with PIP5K1B and Lymphoma
 Neoplasms Antibodies  >1 publications with PIP5K1B and Neoplasms

Organs/Tissues associated with anti-PIP5K1B antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >3 publications with PIP5K1B and Kidney
 Brain Antibodies  >2 publications with PIP5K1B and Brain
 Blood Antibodies  >1 publications with PIP5K1B and Blood
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