SLC17A8 Antibody – Rabbit Polyclonal

Vesicular glutamate transporter (VGLUT) is responsible for the active transport of L-glutamate in synaptic vesicles and thus plays an essential role in the glutamatergic chemical transmission in the central nervous system. VGLUT comprises three isoforms, VGLUT1, 2, and 3, and is a potential marker for the glutamatergic phenotype. Recent studies indicated that VGLUT is also expressed in non-neuronal cells, and localized with various organelles such as synaptic-like microvesicles in the pineal gland, and hormone- containing secretory granules in endocrine cells. L-Glutamate is stored in these organelles, secreted upon various forms of stimulation, and then acts as a paracrine-like modulator. Thus, VGLUTs highlight a novel framework of glutamatergic signaling and reveal its diverse modes of action.

VGLUT3 expression is restricted to the brain, where it is predominantly located in synaptic vesicles. VGLUT3 shows strong sequence homology (~73%) to Differentiation-associated Na- dependent inorganic phosphate cotransporter. Mouse and rat respectively show 90 and 92% identity with the human VGLUT3 protein sequence.

Small volumes of anti-SLC17A8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS624051 is an antibody targeting SLC17A8. Also known as Anti-VGLUT3 (Vesicular Glutamate Transporter 3, Solute Carrier Family 17 Member 8, SLC17A8). Reactive in Human. Host: Rabbit.