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FXYD Domain-Containing Ion Transport Regulator 1 (FXYD3) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS624165

This gene encodes a member of the FXYD family of small membrane proteins that share a 35aa signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The protein encoded by this gene is a plasma… More details

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Product Overview

Online Datasheet in PDF
Product Name
FXYD Domain-containing Ion Transport Regulator 1 (FXYD3), Polyclonal Antibody
Full Product Name
FXYD Domain-containing Ion Transport Regulator 1, phosphorylated (Ser88) (Phospholemman, PLM, Fxyd1, Plm)
Product Gene Name
anti-FXYD3 antibody
Product Synonym Names
Anti -FXYD Domain-containing Ion Transport Regulator 1, phosphorylated (Ser88) (Phospholemman, PLM, Fxyd1, Plm)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes mouse PLM when phosphorylated at Ser88.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
9,263 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (35606732..35615228). Location: 19q13.12
OMIM
604996
3D Structure
ModBase 3D Structure for Q14802
Immunogen
Synthetic phosphopeptide corresponding to amino acid residues surrounding Ser88 of mouse PLM (KLH).

Product Categories/Family for anti-FXYD3 antibody

Antibodies; Abs to Ion Channel
Applications Tested/Suitable for anti-FXYD3 antibody
ELISA (EL/EIA), Western Blot (WB), Gel Shift Assay (GS/EMSA)
Application Notes for anti-FXYD3 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

Dot Blot (DB) of anti-FXYD3 antibody

Dot blot analysis of anti-Phospho-mPLM-pS88.repeat Phospho-specific Pab on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.
Rabbit Anti-FXYD3 Polyclonal Antibody – Cat# MBS624165

Testing Data of anti-FXYD3 antibody

The anti-Mouse Phospho-PLM-pS88 Pab is used for detection in mouse heart tissue lysate. Mouse Phospho-PLM-pS88 (arrow) was detected using the purified Pab.
Rabbit Anti-FXYD3 Polyclonal Antibody, Testing Data – Cat# MBS624165

Other Notes

Small volumes of anti-FXYD3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FXYD3 purchase

MBS624165 is an antibody targeting FXYD3. Also known as FXYD Domain-containing Ion Transport Regulator 1, phosphorylated (Ser88) (Phospholemman, PLM, Fxyd1, Plm). Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FXYD3. It may not necessarily be applicable to this product.

NCBI GI #
5174635
NCBI GeneID
5349
NCBI Accession #
NP_005962.1
UniProt Primary Accession #
Q14802
UniProt Secondary Accession #
Q13211; Q6IB59; A6NDE0; C9JDU2; F5H174; F8WB34
UniProt Related Accession #
Q14802
GenBank Nucleotide #
NM_005971.3
NCBI Official Full Name
FXYD domain-containing ion transport regulator 3 isoform 1
NCBI Official Synonym Full Names
FXYD domain containing ion transport regulator 3
NCBI Official Symbol
FXYD3
NCBI Official Synonym Symbols
MAT8; PLML
UniProt Protein Name
FXYD domain-containing ion transport regulator 3
UniProt Synonym Protein Names
Chloride conductance inducer protein Mat-8; Mammary tumor 8 kDa protein; Phospholemman-like
Protein Family
FXYD domain-containing ion transport regulator
UniProt Gene Name
FXYD3
UniProt Synonym Gene Names
MAT8; PLML
UniProt Entry Name
FXYD3_HUMAN
NCBI Protein Information
FXYD domain-containing ion transport regulator 3; phospholemman-like protein; mammary tumor 8 kDa protein; chloride conductance inducer protein Mat-8

NCBI Summary for FXYD3

This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
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UniProt Comments for FXYD3

FXYD3: Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May be a modulator capable of activating endogenous oocyte channels. Belongs to the FXYD family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.12

Cellular Component: endoplasmic reticulum membrane; integral to plasma membrane; plasma membrane

Molecular Function: chloride channel activity; ATPase binding

Biological Process: regulation of catalytic activity; chloride transport; transmembrane transport
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Research Articles on FXYD3

1. ExoS facilitates P. aeruginosa penetration through the intestinal epithelial barrier by binding to FXYD3 and thereby impairing the defense function of tight junctions against bacterial penetration.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FXYD3 antibody

 Reference Product  PubMed Publications
 FXYD5 antibody  >2 publications with FXYD3 and FXYD5
 AGR2 antibody  >2 publications with FXYD3 and AGR2
 CDH1 antibody  >1 publications with FXYD3 and CDH1

Pathways associated with anti-FXYD3 antibody

 Products by Pathway  Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Ion Transport By P-type ATPases Pathway antibodies  Ion Transport By P-type ATPases Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-FXYD3 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >17 publications with FXYD3 and Neoplasms
 Carcinoma Antibodies  >9 publications with FXYD3 and Carcinoma
 Breast Neoplasms Antibodies  >6 publications with FXYD3 and Breast Neoplasms
 Urinary Bladder Neoplasms Antibodies  >4 publications with FXYD3 and Urinary Bladder Neoplasms
 Adenocarcinoma Antibodies  >4 publications with FXYD3 and Adenocarcinoma
 Pancreatic Neoplasms Antibodies  >3 publications with FXYD3 and Pancreatic Neoplasms
 Necrosis Antibodies  >2 publications with FXYD3 and Necrosis
 Lung Neoplasms Antibodies  >1 publications with FXYD3 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with FXYD3 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >1 publications with FXYD3 and Liver Neoplasms

Organs/Tissues associated with anti-FXYD3 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >8 publications with FXYD3 and Muscle
 Heart Antibodies  >5 publications with FXYD3 and Heart
 Bladder Antibodies  >5 publications with FXYD3 and Bladder
 Stomach Antibodies  >5 publications with FXYD3 and Stomach
 Brain Antibodies  >5 publications with FXYD3 and Brain
 Intestine Antibodies  >5 publications with FXYD3 and Intestine
 Kidney Antibodies  >4 publications with FXYD3 and Kidney
 Nerve Antibodies  >3 publications with FXYD3 and Nerve
 Ovary Antibodies  >2 publications with FXYD3 and Ovary
 Blood Antibodies  >2 publications with FXYD3 and Blood
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