G-Protein, I Alpha 2 (GIA2) Antibody – Mouse Monoclonal

The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

G-alpha i2: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. Belongs to the G-alpha family. G(i/o/t/z) subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z))

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: nucleoplasm; centrosome; membrane; cytoplasm; plasma membrane; heterotrimeric G-protein complex; midbody; cytosol; vesicle; lipid raft

Molecular Function: GTPase activity; signal transducer activity; protein binding; G-protein-coupled receptor binding; GTP binding; metal ion binding; G-protein beta/gamma-subunit binding

Biological Process: platelet activation; acetylcholine receptor signaling, muscarinic pathway; activation of MAPKK activity; metabolic process; negative regulation of adenylate cyclase activity; regulation of calcium ion transport; cell cycle; signal transduction; negative regulation of synaptic transmission; G-protein coupled receptor protein signaling pathway; synaptic transmission; cell proliferation; cell division; positive regulation of cell proliferation; G-protein signaling, adenylate cyclase inhibiting pathway; blood coagulation; adenosine receptor signaling pathway; gamma-aminobutyric acid signaling pathway; response to nutrient

Disease: Ventricular Tachycardia, Familial