Mouse Anti-NF-H Monoclonal Antibody – Cat# MBS6242292

Neurofilament H (NF-H) Antibody – Mouse Monoclonal

Name: NF-H Antibody; Monoclonal; Mouse; Human/Porcine/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6242292
Price: 985 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6242292

MBS6242292 is an antibody targeting NF-H. Also known as Neurofilament H, 180-220kD (NF-H) (APC). Reactive in Human, Porcine, Rat. Host: Mouse. More details

$985 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Neurofilament H (NF-H), Monoclonal Antibody

Full Product Name

Neurofilament H, 180-220kD (NF-H) (APC)

Product Gene Name

anti-NF-H antibody

Clonality

Monoclonal

Isotype

IgG1

Clone Number

2Q166

Host

Mouse

Species Reactivity

Human, Porcine, Rat

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

Purity/Purification

Purified

Specificity

Reacts with neurofilament 200kD. Species crosseactivity: Human, porcine, rat and other higher vertebrates.

Preparation and Storage

Store at 4 degree C. Do Not Freeze.

Molecular Weight

112,479 Da

Chromosome Location

Chromosome: 22; NC_000022.10 (29876181..29887279). Location: 22q12.2

OMIM

105400

3D Structure

ModBase 3D Structure for P12036

Immunogen

Purified neurofilament polypeptides.

Conjugate

APC

Product Categories/Family for anti-NF-H antibody

Antibodies; Neurofilament

Applications Tested/Suitable for anti-NF-H antibody

Immunohistochemistry (IHC)

Product References and Citations for anti-NF-H antibody

1. Debus, E., Weber, K. & Osborn, M. (1983) Differentation 25, 193-203. 2. Shaw, G., Debus, E. & Weber, K. (1984) Eur. J. Cell Biol. 34, 130-136. 3. Altmannsberger, M. et al. (1982) Lab. Invest. 46, 520-526. 4. Keithley, E.M., et al. (2001). Using the Microwave Oven for Decalcification of Human Temporal Bones. Nat. Temporal bone Registry 9(1), 1-4.

Other Notes

Small volumes of anti-NF-H antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NF-H. It may not necessarily be applicable to this product.

NCBI GI #

32483416

NCBI GeneID

4744

NCBI Accession #

NP_066554.2

UniProt Primary Accession #

P12036

UniProt Secondary Accession #

Q96HF8; Q9UJS7; Q9UQ14; B4DYY4

UniProt Related Accession #

P12036

GenBank Nucleotide #

NM_021076.2

NCBI Official Full Name

neurofilament heavy polypeptide

NCBI Official Synonym Full Names

neurofilament, heavy polypeptide

NCBI Official Symbol

NEFH

NCBI Official Synonym Symbols

NFH

UniProt Protein Name

Neurofilament heavy polypeptide

UniProt Synonym Protein Names

200 kDa neurofilament protein; Neurofilament triplet H protein

Protein Family

Neurofilament heavy polypeptide

UniProt Gene Name

NEFH

UniProt Synonym Gene Names

KIAA0845; NFH; NF-H

UniProt Entry Name

NFH_HUMAN

NCBI Protein Information

neurofilament heavy polypeptide; NF-H; 200 kDa neurofilament protein; neurofilament triplet H protein; neurofilament, heavy polypeptide 200kDa

NCBI Summary for NF-H

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq, Oct 2008]

UniProt Comments for NF-H

NFH: Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins. Belongs to the intermediate filament family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: mitochondrion; axon; cytoplasm; neurofilament

Molecular Function: protein binding, bridging; dynein binding; structural constituent of cytoskeleton; kinesin binding; microtubule binding; structural molecule activity; protein kinase binding

Biological Process: axonogenesis; neurofilament bundle assembly; microtubule cytoskeleton organization and biogenesis; cell projection biogenesis; peripheral nervous system neuron axonogenesis

Disease: Amyotrophic Lateral Sclerosis 1

Research Articles on NF-H

1. CSF and intrathecal levels and CSF/serum ratios of anti-NFH antibodies were increased in the CIS patients early developing multiple sclerosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NF-H antibody

Reference Product	PubMed Publications
NEFL antibody	>3 publications with NF-H and NEFL
PRPH antibody	>1 publications with NF-H and PRPH

Pathways associated with anti-NF-H antibody

Products by Pathway	Pathway Diagram
Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies	Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies	Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram

Diseases associated with anti-NF-H antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>13 publications with NF-H and Nervous System Diseases
Neoplasms Antibodies	>7 publications with NF-H and Neoplasms
Brain Diseases Antibodies	>4 publications with NF-H and Brain Diseases
Drug Toxicity Antibodies	>3 publications with NF-H and Drug Toxicity
Death Antibodies	>3 publications with NF-H and Death
Brain Injuries Antibodies	>2 publications with NF-H and Brain Injuries
Disease Models, Animal Antibodies	>1 publications with NF-H and Disease Models, Animal
Atrophy Antibodies	>1 publications with NF-H and Atrophy
Poisoning Antibodies	>1 publications with NF-H and Poisoning
Neurotoxicity Syndromes Antibodies	>1 publications with NF-H and Neurotoxicity Syndromes

Organs/Tissues associated with anti-NF-H antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>8 publications with NF-H and Brain
Nerve Antibodies	>7 publications with NF-H and Nerve
Spinal Cord Antibodies	>2 publications with NF-H and Spinal Cord
Testis Antibodies	>2 publications with NF-H and Testis
Eye Antibodies	>2 publications with NF-H and Eye
Ear Antibodies	>1 publications with NF-H and Ear
Heart Antibodies	>1 publications with NF-H and Heart
Bone Marrow Antibodies	>1 publications with NF-H and Bone Marrow