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Postsynaptic Density Protein 95 (PSD-95) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6242314

MBS6242314 is an antibody targeting PSD-95. Also known as Postsynaptic Density Protein 95 (PSD-95, PSD95, Discs Large Homolog 4, DLG4, Post-synaptic Density Protein 95, Synapse-associated Protein 90, SAP90, SAP-90) (APC). Reactive in Bovine, Mouse, Rat. Host:… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Postsynaptic Density Protein 95 (PSD-95), Monoclonal Antibody
Full Product Name
Postsynaptic Density Protein 95 (PSD-95, PSD95, Discs Large Homolog 4, DLG4, Post-synaptic Density Protein 95, Synapse-associated Protein 90, SAP90, SAP-90) (APC)
Product Gene Name
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
2Q129
Host
Mouse
Species Reactivity
Bovine, Mouse, Rat
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified
Specificity
Recognizes a protein of ~100kD, which corresponds to the apparent MW of PSD-95. A slightly higher MW band is also detected. In rat brain and mouse brain tissue extracts a band of ~75kD is also present. Species Crossreactivity: Rat, mouse and bovine
Preparation and Storage
Store at 4 degree C. Do Not Freeze.
Molecular Weight
– Da
3D Structure
ModBase 3D Structure for P31016
Immunogen
Recombinant protein corresponding to rat PSD-95.
Conjugate
APC

Product Categories/Family for anti-PSD-95 antibody

Applications Tested/Suitable for anti-PSD-95 antibody
Immunocytochemistry (ICC), Western Blot (WB)

Immunocytochemistry (ICC) of anti-PSD-95 antibody

Immunocytochemistry Analysis: Confocal fluorescent analysis of PC12 using MBS600259 (Red). Actin filaments have been labeled with AlexaFluor® 488 -Phalloidin (Green). Nuclear is stained with DAPI (Blue). Membrane staining positive.
Mouse Anti-PSD-95 Monoclonal Antibody – Cat# MBS6242314

Product References and Citations for anti-PSD-95 antibody

Cho et. al., Neuron. (1992) 9:929-942. Kornau et. al., Science (1995) 269:1737-1740. Kennedy et. al., Trends in Neurosci. (1997) 6:264-268.

Other Notes

Small volumes of anti-PSD-95 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PSD-95. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
disks large homolog 4
NCBI Official Synonym Full Names
discs large MAGUK scaffold protein 4
NCBI Official Symbol
Dlg4
NCBI Official Synonym Symbols
Dlgh4; PSD95; Sap90
UniProt Protein Name
Disks large homolog 4
UniProt Synonym Protein Names
Postsynaptic density protein 95; PSD-95; Synapse-associated protein 90; SAP-90; SAP90
Protein Family
UniProt Gene Name
Dlg4
UniProt Synonym Gene Names
Dlgh4; Psd95; PSD-95; SAP-90; SAP90
NCBI Protein Information
disks large homolog 4

NCBI Summary for PSD-95

a molecular scaffolding protein that binds and clusters N-methyl-D-aspartate receptors at neuronal synapses; may be involved in guanine nucleotide-mediated signal transduction pathway [RGD, Feb 2006]

UniProt Comments for PSD-95

Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-PSD-95 antibody

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