Mouse Anti-SUZ12 Monoclonal Antibody – Cat# MBS6242438

Lysates from HeLa cells were probed with MBS601380 SUZ12, 1:1000. Arrow indicates SUZ12 (95kD).

SUZ12 Antibody – Mouse Monoclonal

Name: SUZ12 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6242438
Price: 1340 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6242438

MBS6242438 is an antibody targeting SUZ12. Also known as SUZ12 (Suppressor of Zeste 12 Protein Homolog, CHET9, JJAZF1, KIAA0160, LOC23512) (APC). Reactive in Human. Host: Mouse. More details

$1340 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SUZ12, Monoclonal Antibody

Full Product Name

SUZ12 (Suppressor of Zeste 12 Protein Homolog, CHET9, JJAZF1, KIAA0160, LOC23512) (APC)

Product Gene Name

anti-SUZ12 antibody

Clonality

Monoclonal

Isotype

IgG1,k

Clone Number

7L26

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Specificity

Recognizes human SUZ12 at 95kD.

Preparation and Storage

Store at 4 degree C. Do Not Freeze.

Molecular Weight

83,055 Da

OMIM

606245

3D Structure

ModBase 3D Structure for Q15022

Immunogen

Recombinant human SUZ12, full length.

Conjugate

APC

Product Categories/Family for anti-SUZ12 antibody

Antibodies; Proteins

Applications Tested/Suitable for anti-SUZ12 antibody

ELISA (EIA), Western Blot (WB)

Product References and Citations for anti-SUZ12 antibody

1. Nucci, Marisa R. et al. (2007). Molecular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms. Am J Surg Pathol 31: 65-70 2. Furuno, Kenji. et al. (2006). Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro. Biochem Biophys Res Commun 345: 1051-8. 3. Lee, Tong Ihn et al. (2006). Control of developmental regulators by Polycomb in human embryonic stem cells. Cell 125: 301-13. 4. Huang, Hsuan-Ying et al. (2004). Molecular detection of JAZF1-JJAZ1 gene fusion in endometrial stromal neoplasms with classic and variant histology: evidence for genetic heterogeneity. Am J Surg Pathol 28: 224-32.

Other Notes

Small volumes of anti-SUZ12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SUZ12. It may not necessarily be applicable to this product.

NCBI GI #

119600664

NCBI GeneID

23512

NCBI Accession #

EAW80258.1

UniProt Primary Accession #

Q15022

UniProt Secondary Accession #

Q96BD9

UniProt Related Accession #

Q15022

GenBank Nucleotide #

NM_015355

NCBI Official Full Name

suppressor of zeste 12 homolog (Drosophila)

NCBI Official Synonym Full Names

SUZ12 polycomb repressive complex 2 subunit

NCBI Official Symbol

SUZ12

NCBI Official Synonym Symbols

CHET9; JJAZ1

UniProt Protein Name

Polycomb protein SUZ12

UniProt Synonym Protein Names

Chromatin precipitated E2F target 9 protein; ChET 9 protein; Joined to JAZF1 protein; Suppressor of zeste 12 protein homolog

Protein Family

Polycomb protein

UniProt Gene Name

SUZ12

UniProt Synonym Gene Names

CHET9; JJAZ1; KIAA0160; ChET 9 protein

UniProt Entry Name

SUZ12_HUMAN

NCBI Protein Information

polycomb protein SUZ12; chET 9 protein; joined to JAZF1 protein; suppressor of zeste 12 homolog; suppressor of zeste 12 protein homolog; chromatin precipitated E2F target 9 protein

NCBI Summary for SUZ12

This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009]

UniProt Comments for SUZ12

SUZ12: a zinc finger protein. A breakpoint translocation of the cognate gene with JAZF1 has been reported in endometrial stromal sarcoma.

Protein type: Oncoprotein; C2H2-type zinc finger protein; Transcription factor

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: nucleoplasm; sex chromatin; ESC/E(Z) complex; nucleolus; nucleus

Molecular Function: histone methyltransferase activity; protein binding; sequence-specific DNA binding; RNA binding; metal ion binding; chromatin binding; methylated histone residue binding

Biological Process: histone methylation; negative regulation of cell differentiation; transcription, DNA-dependent; negative regulation of gene expression, epigenetic; histone ubiquitination; positive regulation of cell proliferation; gene expression; negative regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic

Research Articles on SUZ12

1. provide evidences suggesting that SUZ12 is an oncogene in non-small cell lung cancer

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SUZ12 antibody

Reference Product	PubMed Publications
EZH2 antibody	>119 publications with SUZ12 and EZH2
EED antibody	>76 publications with SUZ12 and EED
EZH1 antibody	>8 publications with SUZ12 and EZH1
ASXL1 antibody	>5 publications with SUZ12 and ASXL1
CTCF antibody	>5 publications with SUZ12 and CTCF
AEBP2 antibody	>4 publications with SUZ12 and AEBP2
RBBP4 antibody	>4 publications with SUZ12 and RBBP4
HDAC2 antibody	>3 publications with SUZ12 and HDAC2
RBBP7 antibody	>3 publications with SUZ12 and RBBP7

Pathways associated with anti-SUZ12 antibody

Products by Pathway	Pathway Diagram
Cellular Senescence Pathway antibodies	Cellular Senescence Pathway Diagram
Cellular Responses To Stress Pathway antibodies	Cellular Responses To Stress Pathway Diagram
Epigenetic Regulation Of Gene Expression Pathway antibodies	Epigenetic Regulation Of Gene Expression Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Oxidative Stress Induced Senescence Pathway antibodies	Oxidative Stress Induced Senescence Pathway Diagram
PRC2 Methylates Histones And DNA Pathway antibodies	PRC2 Methylates Histones And DNA Pathway Diagram

Diseases associated with anti-SUZ12 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>102 publications with SUZ12 and Neoplasms
Cell Transformation, Neoplastic Antibodies	>16 publications with SUZ12 and Cell Transformation, Neoplastic
Nervous System Diseases Antibodies	>15 publications with SUZ12 and Nervous System Diseases
Neoplasm Metastasis Antibodies	>12 publications with SUZ12 and Neoplasm Metastasis
Endometrial Neoplasms Antibodies	>12 publications with SUZ12 and Endometrial Neoplasms
Lung Neoplasms Antibodies	>11 publications with SUZ12 and Lung Neoplasms
Prostatic Diseases Antibodies	>10 publications with SUZ12 and Prostatic Diseases
Adenocarcinoma Antibodies	>9 publications with SUZ12 and Adenocarcinoma
Congenital Abnormalities Antibodies	>6 publications with SUZ12 and Congenital Abnormalities
Inflammation Antibodies	>5 publications with SUZ12 and Inflammation

Organs/Tissues associated with anti-SUZ12 antibody

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>18 publications with SUZ12 and Embryonic Tissue
Prostate Antibodies	>18 publications with SUZ12 and Prostate
Blood Antibodies	>17 publications with SUZ12 and Blood
Brain Antibodies	>14 publications with SUZ12 and Brain
Lung Antibodies	>13 publications with SUZ12 and Lung
Bone Antibodies	>10 publications with SUZ12 and Bone
Liver Antibodies	>8 publications with SUZ12 and Liver
Muscle Antibodies	>7 publications with SUZ12 and Muscle
Bone Marrow Antibodies	>7 publications with SUZ12 and Bone Marrow
Skin Antibodies	>5 publications with SUZ12 and Skin