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Bone Morphogenetic Protein 7 (BMP7) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6242469

MBS6242469 is an antibody targeting BMP7. Also known as Bone Morphogenetic Protein 7 (BMP7, OP-1, Osteogenic Protein-1) (APC). Reactive in Human, Mouse. Host: Mouse. More details

$1390 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Bone Morphogenetic Protein 7 (BMP7), Monoclonal Antibody
Full Product Name
Bone Morphogenetic Protein 7 (BMP7, OP-1, Osteogenic Protein-1) (APC)
Product Gene Name
anti-BMP7 antibody
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
9i148
Host
Mouse
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by Protein G Affinity Chromatography
Specificity
Recognizes human BMP-7 at ~46kD. Species Crossreactivity: mouse.
Preparation and Storage
Store at 4 degree C. Do Not Freeze.
Molecular Weight
49,313 Da
Chromosome Location
Chromosome: 20; NC_000020.10 (55743809..55841707, complement). Location: 20q13
OMIM
112267
3D Structure
ModBase 3D Structure for P18075
Immunogen
Recombinant protein corresponding to full-length human BMP-7.
Conjugate
APC

Product Categories/Family for anti-BMP7 antibody

Antibodies; Receptors; Growth Factor
Applications Tested/Suitable for anti-BMP7 antibody
Immunohistochemistry (IHC), Western Blot (WB)

Immunohistochemistry (IHC) of anti-BMP7 antibody

Immunohistochemistry Analysis: Staining of anti-BMP-7, B2553-34C on normal human kidney medulla (left) and normal human kidney cortex (right). Tissue is first treated with a citrate buffer, pH 6.0 to facilitate antigen retrieval, and then stained with the primary monoclonal antibody at a 1:50 dilution. As expected, immunoreactivity is seen through an epical membrane staining pattern. Images shown at low magnification.
Mouse Anti-BMP7 Monoclonal Antibody – Cat# MBS6242469

Western Blot (WB) of anti-BMP7 antibody

Western Blot Analysis: Mouse kidney cell lysates were resolved by electrophoresis, transferred to PVDF and probed with anti-BMP-7, B2553-34C (1ug/ml). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and a chemiluminescence detection system. Arrow indicates ~46kD.
Mouse Anti-BMP7 Monoclonal Antibody, Western Blot (WB) – Cat# MBS6242469

Product References and Citations for anti-BMP7 antibody

1. Lavery, K., et al. (2009). Bone. 45(1):27-41. 2. Wang, L., et al. (2009). IFMBE Proceedings. 23:1369-1372. 3. Knippenberg, M., et al. (2006). Biochem Biophys Res Comm. 342(2):902-908. 4. Komaki, M., et al. (2004). J Cell Science. 117:1457-1468. 5. Shea, C., et al. (2003). Cell. Biochem. 90(6):1112-1127.

Other Notes

Small volumes of anti-BMP7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for BMP7. It may not necessarily be applicable to this product.

NCBI GI #
4502427
NCBI GeneID
655
NCBI Accession #
NP_001710.1
UniProt Primary Accession #
P18075
UniProt Secondary Accession #
Q9H512; Q9NTQ7
UniProt Related Accession #
P18075
GenBank Nucleotide #
NM_001719.2
NCBI Official Full Name
bone morphogenetic protein 7
NCBI Official Synonym Full Names
bone morphogenetic protein 7
NCBI Official Symbol
BMP7
NCBI Official Synonym Symbols
OP-1
UniProt Protein Name
Bone morphogenetic protein 7
UniProt Synonym Protein Names
Osteogenic protein 1
Protein Family
Bone morphogenetic protein
UniProt Gene Name
BMP7
UniProt Synonym Gene Names
OP1; BMP-7; OP-1
UniProt Entry Name
BMP7_HUMAN
NCBI Protein Information
bone morphogenetic protein 7; osteogenic protein 1

NCBI Summary for BMP7

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. [provided by RefSeq, Jul 2008]
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UniProt Comments for BMP7

BMP7: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1. Expressed in the kidney and bladder. Lower levels seen in the brain. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20q13

Cellular Component: extracellular matrix; extracellular space; extracellular region

Molecular Function: heparin binding; protein binding; growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: negative regulation of MAP kinase activity; axon guidance; response to peptide hormone stimulus; extracellular matrix organization and biogenesis; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; negative regulation of NF-kappaB import into nucleus; embryonic pattern specification; response to estradiol stimulus; negative regulation of cell cycle; BMP signaling pathway; regulation of apoptosis; response to vitamin D; epithelial cell differentiation; ureteric bud development; dendrite development; mesonephros development; skeletal development; embryonic limb morphogenesis; ossification; positive regulation of heterotypic cell-cell adhesion; positive regulation of bone mineralization; odontogenesis of dentine-containing teeth; positive regulation of osteoblast differentiation; negative regulation of neuron differentiation; mesenchymal cell differentiation; branching morphogenesis of a tube; mesoderm formation; inhibition of NF-kappaB transcription factor; cartilage development; negative regulation of mitosis; epithelial to mesenchymal transition; negative regulation of phosphorylation; negative regulation of Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; embryonic camera-type eye morphogenesis; negative regulation of transcription, DNA-dependent; metanephros development; neurite morphogenesis; growth
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Research Articles on BMP7

1. There is efficient and reproducible induction of SZP/lubricin accumulation by TGF-beta1 and BMP-7 in skeletal muscle-derived mesenchymal stem cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BMP7 antibody

 Reference Product  PubMed Publications
 BMPR2 antibody  >112 publications with BMP7 and BMPR2
 BMPR1A antibody  >69 publications with BMP7 and BMPR1A
 SMAD5 antibody  >41 publications with BMP7 and SMAD5
 BMPR1B antibody  >23 publications with BMP7 and BMPR1B
 ACVR1 antibody  >21 publications with BMP7 and ACVR1
 ACVR2A antibody  >5 publications with BMP7 and ACVR2A
 SOSTDC1 antibody  >4 publications with BMP7 and SOSTDC1
 SMAD9 antibody  >3 publications with BMP7 and SMAD9
 FST antibody  >3 publications with BMP7 and FST
 NOG antibody  >3 publications with BMP7 and NOG

Pathways associated with anti-BMP7 antibody

 Products by Pathway  Pathway Diagram
 ALK2 Signaling Events Pathway antibodies  ALK2 Signaling Events Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Molecules Associated With Elastic Fibres Pathway antibodies  Molecules Associated With Elastic Fibres Pathway Diagram

Diseases associated with anti-BMP7 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >131 publications with BMP7 and Neoplasms
 Disease Models, Animal Antibodies  >87 publications with BMP7 and Disease Models, Animal
 Kidney Diseases Antibodies  >82 publications with BMP7 and Kidney Diseases
 Nervous System Diseases Antibodies  >51 publications with BMP7 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >44 publications with BMP7 and Cardiovascular Diseases
 Inflammation Antibodies  >39 publications with BMP7 and Inflammation
 Necrosis Antibodies  >31 publications with BMP7 and Necrosis
 Bone Resorption Antibodies  >30 publications with BMP7 and Bone Resorption
 Renal Insufficiency Antibodies  >28 publications with BMP7 and Renal Insufficiency
 Hypertension Antibodies  >26 publications with BMP7 and Hypertension

Organs/Tissues associated with anti-BMP7 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1219 publications with BMP7 and Bone
 Kidney Antibodies  >180 publications with BMP7 and Kidney
 Embryonic Tissue Antibodies  >163 publications with BMP7 and Embryonic Tissue
 Connective Tissue Antibodies  >140 publications with BMP7 and Connective Tissue
 Brain Antibodies  >99 publications with BMP7 and Brain
 Muscle Antibodies  >93 publications with BMP7 and Muscle
 Mouth Antibodies  >83 publications with BMP7 and Mouth
 Eye Antibodies  >67 publications with BMP7 and Eye
 Prostate Antibodies  >35 publications with BMP7 and Prostate
 Heart Antibodies  >33 publications with BMP7 and Heart
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