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Laminin 5 (LAMC2) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6242803

MBS6242803 is an antibody targeting LAMC2. Also known as Laminin 5 (Laminin gamma 2) (Biotin). Reactive in Human. Host: Mouse. More details

$1390 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Laminin 5 (LAMC2), Monoclonal Antibody
Full Product Name
Laminin 5 (Laminin gamma 2) (Biotin)
Product Gene Name
anti-LAMC2 antibody
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2Q586
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes the 150kD (precursor form) and 105kD (mature form) chain proteins of human Laminin 5. No reactivity is expected with other laminin types, as the gamma 2 chain of laminin is unique to Laminin 5. Strong positive staining is seen in basement membrane of the following tissues: skin, esophagus, lung and kidney. Positive staining is also seen in stomach, small intestine, spleen, thymus, prostate and ovary. Thyroid, testis, skeletal and cardiac muscle were negative for Laminin 5 staining.
Preparation and Storage
Store at -20 degree C.
Molecular Weight
121,604 Da
OMIM
150292
3D Structure
ModBase 3D Structure for Q13753
Immunogen
GST fusion protein expressing aa382-608 of human laminin gamma 2 chain (III domain) (NP_005553).
Conjugate
Biotin

Product Categories/Family for anti-LAMC2 antibody

Antibodies; Lamin; Laminin
Applications Tested/Suitable for anti-LAMC2 antibody
ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

Western Blot (WB) of anti-LAMC2 antibody

Western Blot Analysis: Representative lot data. Human recombinant laminin-5 was resolved by electrophoresis, transferred to PVDF membrane and probed with L1225-35 (1:1000 dilution). Proteins were visualized using an IgG (HRP) goat anti-mouse and a chemiluminescence detection system. Bands indicate both the pre- cursor and mature forms of Laminin-5 (~105 & 150kD).
Mouse Anti-LAMC2 Monoclonal Antibody – Cat# MBS6242803

Western Blot (WB) of anti-LAMC2 antibody

Western Blot Analysis: Representative lot data. Human Placenta lysate was resolved by electrophoresis, transferred to PVDF membrane and probed with L1225-35 (1:500 dilution). Proteins were visualized using an IgG (HRP) goat anti-mouse and a chemiluminescence detection system. Arrow indicates the mature form of Laminin-5 (~105kD).
Mouse Anti-LAMC2 Monoclonal Antibody, Western Blot (WB) – Cat# MBS6242803

Product References and Citations for anti-LAMC2 antibody

1. El-Domyati M., et al. Int J Dermatol. 2015 Mar 13. doi: 10.1111/ijd.12532. 2. El-Domyati, M., et al., Egypt J. Derm. & Androl. 29: 81-90 (2009). General References: 1. Mizushima, H., et al., Hormone Research 50: 7-14 (1998). 2. Koshikawa, N., et al., Cancer Res. 59: 5596-5601 (1999). 3. Decline, F. and Rousselle, P., J. of Cell Sci. 114: 811-823 (2000). 4. Neurieiter, D., et al., Pancreatology 5: 387-398 (2005). 5. Petty, A.P., et al., Am. J. Pathol. 170: 1763-1780 (2007).

Other Notes

Small volumes of anti-LAMC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LAMC2. It may not necessarily be applicable to this product.

NCBI GI #
157419138
NCBI GeneID
3918
NCBI Accession #
NP_005553
UniProt Primary Accession #
Q13753
UniProt Secondary Accession #
Q02536; Q02537; Q13752; Q14941; Q14DF7; Q2M1N2; Q5VYE8
UniProt Related Accession #
Q13753
GenBank Nucleotide #
NM_005562
NCBI Official Full Name
laminin subunit gamma-2 isoform a
NCBI Official Synonym Full Names
laminin, gamma 2
NCBI Official Symbol
LAMC2
NCBI Official Synonym Symbols
B2T; CSF; EBR2; BM600; EBR2A; LAMB2T; LAMNB2
UniProt Protein Name
Laminin subunit gamma-2
UniProt Synonym Protein Names
Cell-scattering factor 140 kDa subunit; CSF 140 kDa subunit; Epiligrin subunit gamma; Kalinin subunit gamma; Kalinin/nicein/epiligrin 100 kDa subunit; Ladsin 140 kDa subunit; Laminin B2t chain; Laminin-5 subunit gamma; Large adhesive scatter factor 140 kDa subunit; Nicein subunit gamma
Protein Family
Laminin
UniProt Gene Name
LAMC2
UniProt Synonym Gene Names
LAMB2T; LAMNB2; CSF 140 kDa subunit
UniProt Entry Name
LAMC2_HUMAN
NCBI Protein Information
laminin subunit gamma-2; BM600-100kDa; CSF 140 kDa subunit; cell-scattering factor 140 kDa subunit; epiligrin subunit gamma; kalinin subunit gamma; ladsin 140 kDa subunit; laminin B2t chain; large adhesive scatter factor 140 kDa subunit; nicein subunit ga

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LAMC2 antibody

 Reference Product  PubMed Publications
 LAMB3 antibody  >48 publications with LAMC2 and LAMB3
 COL7A1 antibody  >3 publications with LAMC2 and COL7A1
 BMP1 antibody  >1 publications with LAMC2 and BMP1

Pathways associated with anti-LAMC2 antibody

 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Anchoring Fibril Formation Pathway antibodies  Anchoring Fibril Formation Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram

Diseases associated with anti-LAMC2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >98 publications with LAMC2 and Neoplasms
 Carcinoma Antibodies  >82 publications with LAMC2 and Carcinoma
 Skin Diseases Antibodies  >53 publications with LAMC2 and Skin Diseases
 EPIDERMOLYSIS BULLOSA, JUNCTIONAL, HERLITZ TYPE Antibodies  >50 publications with LAMC2 and EPIDERMOLYSIS BULLOSA, JUNCTIONAL, HERLITZ TYPE
 Genetic Diseases, Inborn Antibodies  >46 publications with LAMC2 and Genetic Diseases, Inborn
 Congenital Abnormalities Antibodies  >45 publications with LAMC2 and Congenital Abnormalities
 Carcinoma, Squamous Cell Antibodies  >41 publications with LAMC2 and Carcinoma, Squamous Cell
 Neoplasm Invasiveness Antibodies  >38 publications with LAMC2 and Neoplasm Invasiveness
 Head and Neck Neoplasms Antibodies  >31 publications with LAMC2 and Head and Neck Neoplasms
 Adenocarcinoma Antibodies  >28 publications with LAMC2 and Adenocarcinoma

Organs/Tissues associated with anti-LAMC2 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >52 publications with LAMC2 and Skin
 Mouth Antibodies  >21 publications with LAMC2 and Mouth
 Lung Antibodies  >13 publications with LAMC2 and Lung
 Lymph Node Antibodies  >10 publications with LAMC2 and Lymph Node
 Embryonic Tissue Antibodies  >9 publications with LAMC2 and Embryonic Tissue
 Bone Antibodies  >7 publications with LAMC2 and Bone
 Nerve Antibodies  >7 publications with LAMC2 and Nerve
 Liver Antibodies  >7 publications with LAMC2 and Liver
 Stomach Antibodies  >6 publications with LAMC2 and Stomach
 Eye Antibodies  >6 publications with LAMC2 and Eye
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