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Tissue Inhibitor of Metalloproteinases 1 (TIMP1) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6242873

MBS6242873 is an antibody targeting TIMP1. Also known as Tissue Inhibitor of Metalloproteinases 1 (Erythroid Potentiating Activity, EPA, Collagenase Inhibitor, CI) (Biotin). Reactive in Bovine, Human, Rat. Host: Mouse. More details

$1320 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Tissue Inhibitor of Metalloproteinases 1 (TIMP1), Monoclonal Antibody
Full Product Name
Tissue Inhibitor of Metalloproteinases 1 (Erythroid Potentiating Activity, EPA, Collagenase Inhibitor, CI) (Biotin)
Product Gene Name
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
2Q760
Host
Mouse
Species Reactivity
Bovine, Human, Rat
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified IgG
Specificity
Recognizes bovine TIMP-1. Crossreacts with human and rat TIMP-1. Does not react with mouse TIMP-1.
Preparation and Storage
Store at -20 degree C.
Molecular Weight
23,032 Da
Chromosome Location
Chromosome: X; AC_000187.1 (91232235..91236073). Location: chromosome: X
3D Structure
ModBase 3D Structure for P20414
Immunogen
Bovine TIMP-1
Conjugate
Biotin
Applications Tested/Suitable for anti-TIMP1 antibody
ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

Product References and Citations for anti-TIMP1 antibody

1. Kodama, S. et al. (1987). Monoclonal antibodies to bovine collagenase inhibitor. Collagen Rel. Res. 7: 341- 350. 2. Okada, Y. et al. (1989). Immunolocalization of matrix metallo-proteinases 3 (stromelysin) in rheumatoid synovioblasts (B cells): correlation with rheumatoid arthritis. Ann. Rheum. Dis. 48: 645-653. 3. Fukuda, Y. et al. (1991). Immunohistochemical study on tissue inhibitors of metalloproteinases in normal and pathological human livers. Gastroenterol. Jpn. 26: 37- 41. 4. Attiga, FA., Fernandez, PM, Weeraratna, AT, Manyak, MJ, and S. Patierno. (2000) "Inhibitors of Prostaglandin Synthsis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases." Cancer Research 60:4629-4637

Other Notes

Small volumes of anti-TIMP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TIMP1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
TIMP-1
NCBI Official Synonym Full Names
TIMP metallopeptidase inhibitor 1
NCBI Official Symbol
TIMP1
UniProt Protein Name
Metalloproteinase inhibitor 1
UniProt Synonym Protein Names
Embryogenin-1; EG-1; Tissue inhibitor of metalloproteinases 1
UniProt Gene Name
TIMP1
UniProt Synonym Gene Names
EG-1; TIMP-1
UniProt Entry Name
TIMP1_BOVIN
NCBI Protein Information
metalloproteinase inhibitor 1; EG-1; TIMP-1; embryogenin-1; tissue inhibitor of metalloproteinases 1; tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor)

UniProt Comments for TIMP1

Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.

Subcellular location: Secreted.

Post-translational modification: The activity of TIMP1 is dependent on the presence of disulfide bonds.

Sequence similarities: Belongs to the protease inhibitor I35 (TIMP) family. [View classification]Contains 1 NTR domain.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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