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BRSK2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS624293

BRSK2 expressed in insect cells specifically phosphorylates WEE1A, CDC25C, and CDC25B in an in vitro assay, but a kinase-dead mutant does not. Overexpression of BRSK2 in HeLa cells results in increased phosphorylation of CDC25C. DNA damage induced by… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
BRSK2, Polyclonal Antibody
Full Product Name
BRSK2, CT (BR Serine/Threonine-protein Kinase 2, Serine/Threonine-protein Kinase 29, Serine/Threonine-protein Kinase SAD-A, C11orf7, PEN11B, STK29, HUSSY-12)
Product Gene Name
anti-BRSK2 antibody
Product Synonym Names
Anti -BRSK2, CT (BR Serine/Threonine-protein Kinase 2, Serine/Threonine-protein Kinase 29, Serine/Threonine-protein Kinase SAD-A, C11orf7, PEN11B, STK29, HUSSY-12)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human STK29.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
20,920 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (1411129..1483332). Location: 11p15.5
3D Structure
ModBase 3D Structure for Q6ZWB1
Immunogen
Synthetic peptide selected from the C-terminal region of human STK29 (KLH).

Product Categories/Family for anti-BRSK2 antibody

Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-BRSK2 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-BRSK2 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-BRSK2 antibody

Western blot analysis of anti-STK29 Pab in HL60 cell line lysate (35ug/lane). STK29(arrow) was detected using the purified Pab.
Rabbit Anti-BRSK2 Polyclonal Antibody – Cat# MBS624293

Immunohistochemistry (IHC) of anti-BRSK2 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-BRSK2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS624293

Other Notes

Small volumes of anti-BRSK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BRSK2 purchase

MBS624293 is an antibody targeting BRSK2. Also known as BRSK2, CT (BR Serine/Threonine-protein Kinase 2, Serine/Threonine-protein Kinase 29, Serine/Threonine-protein Kinase SAD-A, C11orf7, PEN11B, STK29, HUSSY-12). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BRSK2. It may not necessarily be applicable to this product.

NCBI GI #
116089335
NCBI GeneID
9024
NCBI Accession #
NP_003948.2
UniProt Primary Accession #
Q6ZWB1
UniProt Related Accession #
Q6ZWB1; Q8IWQ3
GenBank Nucleotide #
NM_003957.2
NCBI Official Full Name
BR serine/threonine-protein kinase 2
NCBI Official Synonym Full Names
BR serine/threonine kinase 2
NCBI Official Symbol
BRSK2
NCBI Official Synonym Symbols
SAD1; STK29; PEN11B; C11orf7; FLJ41362
UniProt Protein Name
cDNA FLJ41362 fis, clone BRCAN2003703, highly similar to Homo sapiens putative serine/threonine protein kinase
Protein Family
Serine/threonine-protein kinase
UniProt Entry Name
Q6ZWB1_HUMAN
NCBI Protein Information
BR serine/threonine-protein kinase 2; OTTHUMP00000235105; OTTHUMP00000235106; OTTHUMP00000235107; OTTHUMP00000235108; OTTHUMP00000235109; OTTHUMP00000235112; OTTHUMP00000235113; protein kinase SAD1B; serine/threonine kinase 29; serine/threonine kinase SAD-A; serine/threonine-protein kinase 29; serine/threonine-protein kinase SAD-A

UniProt Comments for BRSK2

BRSK2: a serine/threonine protein kinase of the CAMK group. Closely related to AMPK. Activated by the kinase LKB1. BRSK1 and BRSK2 are required for nueronal polarization. Expressed in the brain and at low levels in the testis. Four alternatively spliced isoforms have been described.

Protein type: EC 2.7.11.26; EC 2.7.11.1; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); CAMK group; CAMKL family; BRSK subfamily

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: centrosome; endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm

Molecular Function: protein serine/threonine kinase activity; tau-protein kinase activity; magnesium ion binding; protein kinase binding; ATP binding

Biological Process: neuron differentiation; mitosis; peptidyl-serine phosphorylation; exocytosis; axonogenesis; cell division; establishment of cell polarity; actin cytoskeleton reorganization; G2/M transition of mitotic cell cycle; protein amino acid phosphorylation
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Research Articles on BRSK2

1. BRSK2 is up-regulated in pancreatic ductal adenocarcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BRSK2 antibody

 Reference Product  PubMed Publications
 WEE1 antibody  >1 publications with BRSK2 and WEE1

Pathways associated with anti-BRSK2 antibody

 Products by Pathway  Pathway Diagram
 LKB1 Signaling Events Pathway antibodies  LKB1 Signaling Events Pathway Diagram

Diseases associated with anti-BRSK2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2 publications with BRSK2 and Neoplasms

Organs/Tissues associated with anti-BRSK2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with BRSK2 and Brain
 Lung Antibodies  >1 publications with BRSK2 and Lung
 Testis Antibodies  >1 publications with BRSK2 and Testis
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