Rat Anti-CTH-1 Monoclonal Antibody – Cat# MBS6243020

Western Blotting Analysis: Representative lot data. Jurkat cell lysate was probed with 0.5 ug/mL of Anti-Cytohesin-1, clone 7H2. Proteins were visualized using a Goat Anti-Rat IgG secondary antibody conjugated to HRP and detected using a chemiluminescence detection system. Arrow indicates Cytohesin-1 (~46 kD).

Cytohesin 1 (CTH-1) Antibody – Rat Monoclonal

Name: CTH-1 Antibody; Monoclonal; Rat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6243020
Price: 950 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6243020

MBS6243020 is an antibody targeting CTH-1. Also known as Cytohesin 1 (B2-1, CLM1, CTH-1, CYTIP, Cytoadhesin 1, D17S811E, Homolog of Secretory Protein SEC7, Pleckstrin Homology Sec7 and Coiled/Coil Domains 1, PSCD1) (Biotin). Reactive in Human. Host: Rat. More details

$950 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Cytohesin 1 (CTH-1), Monoclonal Antibody

Full Product Name

Cytohesin 1 (B2-1, CLM1, CTH-1, CYTIP, Cytoadhesin 1, D17S811E, Homolog of Secretory Protein SEC7, Pleckstrin Homology Sec7 and Coiled/Coil Domains 1, PSCD1) (Biotin)

Product Gene Name

anti-CTH-1 antibody

Clonality

Monoclonal

Isotype

IgG1,k

Clone Number

10H4

Host

Rat

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

Purity/Purification

Purified by Ammonium Sulfate Precipitation

Specificity

Recognizes human Cytohesin-1.

Preparation and Storage

Store at -20 degree C.

Molecular Weight

48.8 kDa (421aa) confirmed by MALDI-TOF

OMIM

182115

3D Structure

ModBase 3D Structure for Q15438

Immunogen

Recombinant protein corresponding to human Cytohesin-1 (Histidine-tagged).

Conjugate

Biotin

Product Categories/Family for anti-CTH-1 antibody

Antibodies; G Proteins

Applications Tested/Suitable for anti-CTH-1 antibody

Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB)

Other Notes

Small volumes of anti-CTH-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CTH-1. It may not necessarily be applicable to this product.

NCBI GI #

4758964

NCBI GeneID

9267

NCBI Accession #

NP_004753

UniProt Primary Accession #

Q15438

UniProt Secondary Accession #

Q9P123; Q9P124; A6NFW7; B7Z1T4

UniProt Related Accession #

Q15438

GenBank Nucleotide #

NM_004762.3

NCBI Official Full Name

cytohesin-1 isoform 1

NCBI Official Synonym Full Names

cytohesin 1

NCBI Official Symbol

CYTH1

NCBI Official Synonym Symbols

B2-1; SEC7; PSCD1; D17S811E; CYTOHESIN-1

UniProt Protein Name

Cytohesin-1

UniProt Synonym Protein Names

PH, SEC7 and coiled-coil domain-containing protein 1; SEC7 homolog B2-1

Protein Family

Cytohesin

UniProt Gene Name

CYTH1

UniProt Synonym Gene Names

D17S811E; PSCD1

UniProt Entry Name

CYH1_HUMAN

NCBI Protein Information

cytohesin-1

NCBI Summary for CTH-1

The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

UniProt Comments for CTH-1

cytohesin 1: Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF through replacement of GDP with GTP. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, ARF; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; Golgi membrane; plasma membrane

Molecular Function: ARF guanyl-nucleotide exchange factor activity; protein binding

Biological Process: regulation of cell adhesion; vesicle-mediated transport

Research Articles on CTH-1

1. CYTH1 is a novel major regulator of adhesion and engraftment in human hematopoietic stem and progenitor cells through mechanisms that, at least in part, involve the activation of integrins.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CTH-1 antibody

Reference Product	PubMed Publications
ARF6 antibody	>1 publications with CTH-1 and ARF6
ARF1 antibody	>1 publications with CTH-1 and ARF1

Pathways associated with anti-CTH-1 antibody

Products by Pathway	Pathway Diagram
Class I PI3K Signaling Events Pathway antibodies	Class I PI3K Signaling Events Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram
Intra-Golgi And Retrograde Golgi-to-ER Traffic Pathway antibodies	Intra-Golgi And Retrograde Golgi-to-ER Traffic Pathway Diagram
Intra-Golgi Traffic Pathway antibodies	Intra-Golgi Traffic Pathway Diagram
Membrane Trafficking Pathway antibodies	Membrane Trafficking Pathway Diagram
Phospholipase D Signaling Pathway antibodies	Phospholipase D Signaling Pathway Diagram
Phospholipase D Signaling Pathway antibodies	Phospholipase D Signaling Pathway Diagram
Vesicle-mediated Transport Pathway antibodies	Vesicle-mediated Transport Pathway Diagram

Organs/Tissues associated with anti-CTH-1 antibody

Organ/Tissue Name	Pubmed Publications
Placenta Antibodies	>1 publications with CTH-1 and Placenta
Embryonic Tissue Antibodies	>1 publications with CTH-1 and Embryonic Tissue
Connective Tissue Antibodies	>1 publications with CTH-1 and Connective Tissue
Uterus Antibodies	>1 publications with CTH-1 and Uterus
Muscle Antibodies	>1 publications with CTH-1 and Muscle
Blood Antibodies	>1 publications with CTH-1 and Blood